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Vol.40 No.3 (281 in total) Mar. 2024
Theme Issue: Attention to Chronic HBV Infection and Metabolic Dysfunction
Executive Chief Editor: LI Jie  
Affiliated Drum Tower Hospital of Nanjing University Medical School
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Editorial
Chronic hepatitis B virus infection and metabolic associated fatty liver disease： The known and unknown aspects
Nan GENG, Wenjing NI, Fajuan RUI, Jie LI
2024, 40(3): 441-445. DOI: 10.12449/JCH240301
Abstract(718) HTML (164) PDF (591KB)(232) Cited By (1)
Abstract:
Chronic hepatitis B virus （HBV） infection is the main cause of the disease burden of viral hepatitis worldwide， and meanwhile， due to changes in lifestyle and dietary habits， the incidence rate of metabolic associated fatty liver disease （MAFLD） is constantly increasing， making MAFLD the leading chr...
Expert Forum
Basic research on chronic hepatitis B virus infection and metabolic dysfunction： Advances and controversies
Borong YU, Yuanwen CHEN
2024, 40(3): 446-452. DOI: 10.12449/JCH240302
Abstract(654) HTML (269) PDF (732KB)(158) Cited By (2)
Abstract:
Hepatitis B virus （HBV） is considered a “metabolic virus” that can influence a variety of metabolic processes. There is still a lack of definite conclusion on the association between chronic HBV infection and the various types of metabolic dysfunction， and little is known about the mechanism of the ...
Epidemiology and clinical outcome of chronic hepatitis B virus infection and metabolic dysfunction
Jiaofeng HUANG, Qi ZHENG
2024, 40(3): 453-456. DOI: 10.12449/JCH240303
Abstract(484) HTML (144) PDF (586KB)(100)
Abstract:
Chronic hepatitis B virus （HBV） infection is a worldwide public health issue and a leading cause of liver fibrosis， liver cirrhosis， liver failure， and primary liver cancer in China. The incidence rate of nonalcoholic fatty liver disease （NAFLD） is gradually increasing with the improvement in the li...
Clinical management of chronic hepatitis B virus infection comorbid with metabolic dysfunction
Luping YANG, Junping SHI
2024, 40(3): 457-460. DOI: 10.12449/JCH240304
Abstract(435) HTML (179) PDF (572KB)(115)
Abstract:
With the rapid growth of metabolic dysfunction （MD） worldwide， there is also a gradual increase in the number of patients with chronic hepatitis B virus （HBV） infection and MD. Comorbidity with metabolic disorders such as hyperglycemia， hypertension， and dyslipidemia may increase the risk of adverse...
Guideline
Guidelines for traditional Chinese medicine diagnosis and treatment of liver cirrhosis
Branch of Hepatobiliary Diseases， China Association of Chinese Medicine
2024, 40(3): 461-472. DOI: 10.12449/JCH240305
Abstract(1572) HTML (570) PDF (1106KB)(381) Cited By (4)
Abstract:
In recent years， with the advances in basic and clinical research， medical workers have gained a deeper understanding of the clinical diagnosis and treatment of liver cirrhosis， and meanwhile， more studies have been conducted on the traditional Chinese medicine （TCM） syndromes and integrated traditi...
Expert consensus on the molecular diagnosis of early-stage pancreatic cancer （2023 edition）
Professional Committee on Clinical Precision Medicine, Chinese Medical Doctor Association
2024, 40(3): 473-477. DOI: 10.12449/JCH240306
Abstract(1022) HTML (1189) PDF (632KB)(448) Cited By (1)
Abstract:
Pancreatic cancer is a relatively common tumor of the digestive system， with difficulties in early-stage diagnosis and an extremely high degree of malignancy. Molecular diagnostic technology based on tumor biomarkers， combined with the existing gold standard in clinical practice， is of great clinica...
Key points of the international Kyoto guidelines for the management of intraductal papillary mucinous neoplasm of the pancreas （2023）
Jiasu LI, Hongxin SUN, Zhaoshen LI
2024, 40(3): 478-482. DOI: 10.12449/JCH240307
Abstract(2061) HTML (1005) PDF (1026KB)(472)
Abstract:
Recently， the International Association of Pancreatology published a revised edition of the guidelines for the management of intraductal papillary mucinous neoplasm （IPMN） of the pancreas. The guidelines mainly focus on five topics， i.e.， revision of “high-risk stigmata” and “worrisome features”， su...
Viral Hepatitis
Significance of high-sensitivity polymerase chain reaction in detecting hepatitis B virus in chronic hepatitis B patients with a very low viral load
Gongqin QIU, Dan XIE, Ziren CHEN, Shi OUYANG
2024, 40(3): 483-488. DOI: 10.12449/JCH240308
Abstract(919) HTML (301) PDF (702KB)(97) Cited By (2)
Abstract:
Objective To investigate the significance of high-sensitive polymerase chain reaction （PCR） in detecting hepatitis B virus （HBV） among the population with a very low viral load （HBV DNA 10‍ — ‍99 IU/mL）. Methods This study was conducted among the chronic hepatitis B （CHB） patients who were treated w...
Efficacy of ursodeoxycholic acid in the prevention and treatment of COVID-19 in patients with chronic hepatitis B
Xinyu CUI, Yanyan LI, Na ZHU, Yingying LIN, Xin LI
2024, 40(3): 489-495. DOI: 10.12449/JCH240309
Abstract(746) HTML (379) PDF (795KB)(74)
Abstract:
Objective To investigate the potential effect of ursodeoxycholic acid （UDCA） in the prevention and treatment of COVID-19 in patients with chronic hepatitis B. Methods Clinical data were collected from 324 patients with chronic hepatitis B who were treated in Beijing Ditan Hospital， Capital Medical U...
Autoimmune Liver Disease
Value of alkaline phosphatase level after ursodeoxycholic acid treatment for one month and baseline red blood cell distribution width in predicting the treatment response of primary biliary cholangitis
Nan WANG, Rong HU, Shihui BIAN, Wei ZHONG, Pengfei ZHANG, Youwen TAN
2024, 40(3): 496-501. DOI: 10.12449/JCH240310
Abstract(502) HTML (119) PDF (675KB)(68) Cited By (3)
Abstract:
Objective To investigate the value of baseline red cell distribution width （RDW） and alkaline phosphatase （ALP） level after ursodeoxycholic acid （UDCA） treatment for one month in predicting the response to UDCA treatment in patients with primary biliary cholangitis （PBC）. Methods A retrospective ana...
Role and mechanism of action of Yinchenhao Decoction in inhibiting ferroptosis of hepatocytes in mice with autoimmune hepatitis
Zhurong LI, Chen CHEN, Di GUO, Sixue LYU, Jiawen WU, Na YANG, Yang LIU
2024, 40(3): 502-508. DOI: 10.12449/JCH240311
Abstract(648) HTML (141) PDF (1234KB)(51) Cited By (1)
Abstract:
Objective To investigate the role and mechanism of action of Yinchenhao Decoction in inhibiting ferroptosis of hepatocytes in mice with autoimmune hepatitis. Methods A total of 18 specific pathogen-free female C57BL/6 mice were selected and divided into normal group， model group， and treatment group...
Liver Fibrosis and Liver Cirrhosis
Application value of two-dimensional shear wave elastography and serological models in the staging of liver fibrosis in patients with chronic hepatitis B
Yujie HUANG, Siyi FENG
2024, 40(3): 509-515. DOI: 10.12449/JCH240312
Abstract(345) HTML (113) PDF (1188KB)(49) Cited By (2)
Abstract:
Objective To investigate the value of two-dimensional shear wave elastography （2D-SWE） or serological models used alone or in combination in determining the stage of liver fibrosis in patients with chronic hepatitis B. Methods A retrospective analysis was performed for the clinical data of 327 patie...
Influencing factors for death within 30 days in patients with decompensated hepatitis B cirrhosis and hepatic encephalopathy
Yunyi HUANG, Ke SHI, Xianbo WANG
2024, 40(3): 516-520. DOI: 10.12449/JCH240313
Abstract(462) HTML (151) PDF (734KB)(51)
Abstract:
Objective To investigate the influencing factors for death within 30 days in patients with decompensated hepatitis B cirrhosis and hepatic encephalopathy. Methods A retrospective analysis was performed for 616 patients with hepatitis B cirrhosis and hepatic encephalopathy in Beijing Ditan Hospital f...
Establishment of a nomogram model for predicting liver cirrhosis with esophagogastric variceal bleeding based on aspartate aminotransferase-to-platelet ratio index and platelet-albumin-bilirubin score
Xinyi LI, Jiaojiao LI, Yingying LI, Honghe WEI, Yufan XIONG, Xinchi ZHANG, Wei SUN, Li CHEN
2024, 40(3): 521-526. DOI: 10.12449/JCH240314
Abstract(386) HTML (128) PDF (918KB)(49) Cited By (2)
Abstract:
Objective To investigate the value of aspartate aminotransferase-to-platelet ratio index （APRI） and platelet-albumin-bilirubin （PALBI） score in predicting the risk of esophagogastric variceal bleeding in patients with liver cirrhosis. Methods A total of 119 patients with liver cirrhosis who were adm...
Effect of human umbilical cord mesenchymal stem cells in treatment of mice with liver fibrosis and its mechanism
Pingji LIU, Lichao YAO, Xue HU, Zheng WANG, Zhiyu XIONG, Yingan JIANG
2024, 40(3): 527-532. DOI: 10.12449/JCH240315
Abstract(433) HTML (281) PDF (1806KB)(57)
Abstract:
Objective To investigate the effect of human umbilical cord mesenchymal stem cells （hUCMSCs） in the treatment of mice with liver fibrosis and its mechanism. Methods A total of 18 specific pathogen-free C57BL/6 mice， aged 6 weeks， were selected and divided into control group （n=6）， carbon tetrachlori...
Role of podoplanin in hepatic stellate cell activation and liver fibrosis
Zhiyi WANG, Guangyue YANG, Wei ZHANG, Yaqiong PU, Xin ZHAO, Wenting MA, Xuling LIU, Liu WU, Le TAO, Cheng LIU
2024, 40(3): 533-538. DOI: 10.12449/JCH240316
Abstract(631) HTML (255) PDF (1597KB)(50)
Abstract:
Objective To investigate the role and mechanism of podoplanin （PDPN） in hepatic stellate cell （HSC） activation and liver fibrosis. Methods Liver biopsy samples were collected from 75 patients with chronic hepatitis B who attended Department of Infectious Diseases， Putuo Hospital Affiliated to Shangh...
Liver Neoplasm
Efficacy and safety of cryoablation combined with lenvatinib and anti-PD-1 monoclonal antibody in treatment of unresectable hepatocellular carcinoma
Teng LIU, Xiujuan CHANG, Quanwei HE, Ran XU, Yongping YANG
2024, 40(3): 539-549. DOI: 10.12449/JCH240317
Abstract(345) HTML (266) PDF (1848KB)(57)
Abstract:
Objective To investigate whether anti-PD-1 monoclonal antibody can improve the efficacy and safety of cryoablation combined with lenvatinib in the treatment of unresectable hepatocellular carcinoma （HCC）. Methods A retrospective analysis was performed for 232 patients with unresectable HCC who were ...
Efficacy and safety of transcatheter arterial chemoembolization combined with targeted therapy and immunotherapy in treatment of patients with stage Ⅱ‍b/Ⅲ‍a hepatocellular carcinoma based on China Liver Cancer Staging
Zexin HU, Jiaqing LI, Wanci LI, Binyan ZHONG, Shuai ZHANG, Jian SHEN, Xiaoli ZHU
2024, 40(3): 550-555. DOI: 10.12449/JCH240318
Abstract(541) HTML (206) PDF (641KB)(69) Cited By (2)
Abstract:
Objective To evaluate the efficacy and safety of first-line transcatheter arterial chemoembolization （TACE） combined with targeted therapy and immunotherapy in the treatment of patients with stage Ⅱb/Ⅲa hepatocellular carcinoma （HCC） based on China Liver Cancer Staging （CNLC）. Methods A total of 198...
Other Liver Disease
Clinical efficacy of double plasma molecular absorption system and sequential plasma exchange combined with continuous renal replacement therapy in treatment of acute-on-chronic liver failure with acute kidney injury
Yuan WEN, Juanjuan ZHU
2024, 40(3): 556-561. DOI: 10.12449/JCH240319
Abstract(595) HTML (120) PDF (704KB)(66) Cited By (1)
Abstract:
Objective To investigate the clinical efficacy of double plasma molecular adsorption system （DPMAS） and sequential plasma exchange （PE） combined with continuous renal replacement therapy （CRRT） in the treatment of patients with acute-on-chronic liver failure （ACLF） and acute kidney injury （AKI）. Met...
Influencing factors for the prognosis of patients with drug-induced liver injury and establishment of a nomogram model
Shimei WANG, Shuai JIN, Junru LI, Na WANG, Yan CHEN, Ying CUI, Mingming MA, Xiaoli HU
2024, 40(3): 562-567. DOI: 10.12449/JCH240320
Abstract(434) HTML (157) PDF (852KB)(61) Cited By (1)
Abstract:
Objective To investigate the influencing factors for the clinical outcome of patients with drug-induced liver injury （DILI）， and to establish a nomogram prediction model for validation. Methods A retrospective analysis was performed for the general information and laboratory data of 188 patients wit...
Biliary Disease
Clinical significance of determining the level of biliary calprotectin in patients with cholangiocarcinoma or choledocholithiasis
Tingting JI, Bingqing BAI, Yufang CUI, Shaofei WANG, Jianglong HONG, Yang LI, Junjun BAO, Qiao MEI
2024, 40(3): 568-572. DOI: 10.12449/JCH240321
Abstract(318) HTML (148) PDF (643KB)(36) Cited By (1)
Abstract:
Objective To investigate the difference in the level of biliary calprotectin between patients with cholangiocarcinoma and those with choledocholithiasis. Methods Clinical data and bile samples were collected from 34 patients with cholangiocarcinoma and 78 patients with choledocholithiasis who were d...
Association between the risk of increase in total cholesterol and the risk of cholelithiasis： A bidirectional Mendelian randomization study
Weiwei ZHAO, Xiaoxu DU, Hongyan GE
2024, 40(3): 573-580. DOI: 10.12449/JCH240322
Abstract(750) HTML (267) PDF (2528KB)(65) Cited By (2)
Abstract:
Objective To investigate the association between the risk of increase in total cholesterol （TC） and the risk of cholelithiasis by using bidirectional Mendelian randomization （MR）. Methods The open gwas public database was used to obtain the single nucleotide polymorphism data associated with TC and ...
Case Report
Erythropoietic protoporphyria with liver cirrhosis as the main manifestation： A case report
Zhendong WU, Guoqiang ZHOU, Yan XIANG, Xianling WANG, Jiandong SU, Sichun LIU
2024, 40(3): 581-584. DOI: 10.12449/JCH240323
Abstract(375) HTML (168) PDF (719KB)(77)
Abstract:
Erythropoietic protoporphyria （EPP） is a rare inherited metabolic disease that often involves skin， blood， and nervous systems， and EPP with the main manifestations of severe liver damage and acute abdominal pain is extremely rare. By reviewing the clinical data and genetic testing results of a pati...
ABCB4 gene mutation-associated liver cirrhosis with gallstones： A case report
Wendi LIU, Peng WANG, Heping HU, Huabang ZHOU
2024, 40(3): 585-588. DOI: 10.12449/JCH240324
Abstract(412) HTML (211) PDF (889KB)(54)
Abstract:
The disease spectrum of ABCB4 gene mutation involves various diseases such as progressive familial intrahepatic cholestasis type 3 （PFIC3）， gallstone disease， intrahepatic cholestasis of pregnancy， portal hypertension， liver cirrhosis， and even primary hepatic and biliary malignancies. A young male ...
Review
Application of Mendelian randomization analysis in exploring the etiology of nonalcoholic fatty liver disease
Ziwei GUO, Qingjuan WU, Yongan YE, Lanyu CHEN, Wenliang LYU
2024, 40(3): 589-593. DOI: 10.12449/JCH240325
Abstract(564) HTML (562) PDF (673KB)(96)
Abstract:
Nonalcoholic fatty liver disease （NAFLD） is an abnormal lipid metabolic disorder of the liver characterized by accumulation of a large amount of lipids in the liver， and it is currently the most common liver disease around the world. Mendelian randomization （MR） incorporates genomic data into tradit...
Role of Akkermansia muciniphila in nonalcoholic fatty liver disease
Liting ZHENG, Zhe WANG, Yuchun CHEN, Shanshan LIU, Youcheng XIE, Chuyi LI, Xiaohui YU
2024, 40(3): 594-599. DOI: 10.12449/JCH240326
Abstract(666) HTML (272) PDF (867KB)(72)
Abstract:
Nonalcoholic fatty liver disease （NAFLD） has become the most common chronic liver disease in the world， and it is also one of the main causes of liver cirrhosis and hepatocellular carcinoma， so it is particularly important to curb the development and progression of NAFLD in a timely manner. However，...
Application of magnetic resonance imaging-proton density fat fraction in liver fat quantification
Chen YANG, Shanghai YU, Feipeng XU, Hua ZHANG
2024, 40(3): 600-605. DOI: 10.12449/JCH240327
Abstract(1176) HTML (844) PDF (709KB)(180)
Abstract:
Hepatic steatosis can be observed in chronic liver diseases of different etiologies. The main predisposing factors for hepatic steatosis include chronic viral hepatitis， cholestatic liver disease， alcoholic liver disease， and nonalcoholic fatty liver disease. Simple fatty liver disease is the initia...
Current status of research on the genetic susceptibility of primary biliary cholangitis
Chunmei ZHAO, Di MA, Wenlin TAI
2024, 40(3): 606-610. DOI: 10.12449/JCH240328
Abstract(364) HTML (187) PDF (613KB)(49) Cited By (1)
Abstract:
Primary biliary cholangitis （PBC） is a liver autoimmune disease with a strong genetic tendency characterized by the degeneration and necrosis of bile duct epithelial cells， and it is often observed in middle-aged and elderly women. With the continuous development of genome-wide association studies， ...
Regulatory effect and mechanism of macrophage polarization in liver fibrosis
Xiaoyang BAI, Xu ZHANG, Long HAI, Xiangchun DING
2024, 40(3): 611-615. DOI: 10.12449/JCH240329
Abstract(863) HTML (550) PDF (684KB)(81) Cited By (2)
Abstract:
Liver fibrosis is the healing reaction of chronic liver injury caused by various factors such as viral infection， alcohol， and chemical substances and is a key link in the progression of chronic liver diseases to liver cirrhosis and liver cancer. Liver macrophages are considered important mediators ...
Re-understanding of the mechanism of coagulation disorder in liver cirrhosis
Rongrong SUN, Na HE, Fenna ZHANG, Xinyi ZHANG, Ziyi WANG, Hui WANG, Nana BIAN, Honglin YAN
2024, 40(3): 616-620. DOI: 10.12449/JCH240330
Abstract(1026) HTML (196) PDF (622KB)(118) Cited By (1)
Abstract:
The liver plays an important regulatory role in maintaining the dynamic balance of coagulation and anticoagulation in the body. Such dynamic balance is fragile in patients with liver cirrhosis， and the risk of bleeding can be increased due to reductions in coagulation factors and platelet count and ...
Diagnosis and treatment principles of liver injury induced by antithyroid drugs
Ruitao YANG, Rui YANG, Xun DENG, Senxiang ZENG, Xiaoyan YANG
2024, 40(3): 621-625. DOI: 10.12449/JCH240331
Abstract(535) HTML (399) PDF (990KB)(131)
Abstract:
Pharmacotherapy is the primary treatment method for hyperthyroidism. Antithyroid drugs can induce liver injury， and the diagnosis of drug-induced liver injury is mostly exclusive based on medical history collection， clinical symptoms， serum biochemistry， radiological examination， and histology. Acco...
Mechanism of action of Polygonum multiflorum in inducing liver injury： A study based on signaling pathways
Zihan LIANG, Jiahui LI, Shuang CHENG, Zhuoya YUAN, Wenya RONG, Yajie LIU, Yujie HAO, Ruilin WANG
2024, 40(3): 626-632. DOI: 10.12449/JCH240332
Abstract(791) HTML (430) PDF (1173KB)(79) Cited By (1)
Abstract:
Polygonum multiflorum （PM）， a commonly used Chinese herbal medicine in clinical practice， has been associated with frequent reports of liver injury in recent years， and the medication safety of PM has attracted more and more attention in China and globally. This article reviews the recent research a...
Role of mesenchymal stem cells and their exosomes in the treatment of drug-induced liver injury
Guojing XING, Longlong LUO, Lifei WANG, Shunna WANG, Xiaofeng ZHENG, Lixia LU, Jiucong ZHANG
2024, 40(3): 633-638. DOI: 10.12449/JCH240333
Abstract(420) HTML (341) PDF (908KB)(57)
Abstract:
The incidence rate of drug-induced liver injury （DILI） is increasing year by year with unknown mechanisms， and the treatment methods for DILI mainly include drugs， liver support systems， and liver transplantation， all of which have certain limitations. Therefore， the search for safer and more effect...
Research advances in neutrophil extracellular traps and liver diseases
Zhuoga RENZENG, Kangjie YANG, Yongliang LU, Zhixin WANG, Haijiu WANG
2024, 40(3): 639-643. DOI: 10.12449/JCH240334
Abstract(583) HTML (273) PDF (1014KB)(57)
Abstract:
Neutrophils play an immune defense role by releasing the proteases such as neutrophil elastase and myeloperoxidase to form neutrophil extracellular trap （NET） and participate in the inflammatory response of various liver diseases， but the excessive release of NET may worsen liver tissue damage and h...
Application of endocrine indices and ultrasound examination in the early diagnosis of pediatric pancreatic injury
Mingjun JIN, Rongjuan SUN, Liang DONG, Jianghua ZHAN
2024, 40(3): 644-648. DOI: 10.12449/JCH240335
Abstract(435) HTML (113) PDF (703KB)(35)
Abstract:
The incidence rate of abdominal trauma is increasing year by year in pediatric trauma， and traumatic pancreatic injury should be taken seriously by clinicians. The pancreas is located behind the peritoneum， and it is difficult to make an early diagnosis of pancreatic injury， especially in children w...
Introduction of High - quality Articles in Foreign Journals
Journal of Hepatology｜Capsaicin receptor TRPV1 maintains quiescence of hepatic stellate cells in the liver via recruitment of SARM1
2024, 40(3): 508-508. DOI: 10.12449/JCH2403.gwqkjpwzjj1
Abstract(307) HTML (90) PDF (366KB)(34)
Abstract:
Journal of Hepatology｜Development and validation of a prognostic model for 90-day survival in patients with alcohol-associated cirrhosis and acute decompensation
2024, 40(3): 520-520. DOI: 10.12449/JCH2403.gwqkjpwzjj2
Abstract(205) HTML (98) PDF (305KB)(29)
Abstract:
Acknowledgements
Current reviewers
2024, 40(3): 648-648. DOI: 10.12449/JCH2403.zhixie
Abstract(161) HTML (97) PDF (434KB)(17)
Abstract:
    

The first journal specializing in hepatobiliary and pancreatic diseases in China

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