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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 40 Issue 3
Mar.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(3): 626-632

Mechanism of action of Polygonum multiflorum in inducing liver injury： A study based on signaling pathways

DOI: 10.12449/JCH240332
  • 1.

    First Clinical Medical College of Henan University of Chinese Medicine，Zhengzhou 450000，China

  • 2.

    School of Traditional Chinese Medicine，Southern Medical University，Guangzhou 510405，China

  • 3.

    Department of Traditional Chinese Medicine Hepatology，The Fifth Medical Center of PLA General Hospital，Beijing 100039，China

Research funding:

National Natural Science Foundation of China （General Program） (81673806);

Major Scientific and Technological Issues and Challenges in Medicine and Pharmacy 2020 by the China Association of Medical Education (2020KTY001)

More Information
  • Corresponding author: WANG Ruilin， wrl7905@163.com （ORCID： 0000-0002-7129-016X）
  • Received Date: 2023-07-08
  • Accepted Date: 2023-08-21
  • Published Date: 2024-03-20
    Abstract
  • Polygonum multiflorum （PM）， a commonly used Chinese herbal medicine in clinical practice， has been associated with frequent reports of liver injury in recent years， and the medication safety of PM has attracted more and more attention in China and globally. This article reviews the recent research advances in the signaling pathways and mechanisms of PM in causing drug-induced liver injury （DILI） and aims to provide new ideas for the proper and rational use of PM in clinical practice. The results show that PM is involved in the regulation of various signaling pathways， and it leads to the death of hepatocytes by destroying mitochondrial function， exacerbating bile acid accumulation， and inducing immune response， oxidative stress， and endoplasmic reticulum stress， thereby inducing the development and progression of DILI through multiple targets， pathways， and levels.

     

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