Basic research on chronic hepatitis B virus infection and metabolic dysfunction： Advances and controversies

Borong YU; Yuanwen CHEN

doi:10.12449/JCH240302

Volume 40 Issue 3

Mar. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(3): 446-452

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Basic research on chronic hepatitis B virus infection and metabolic dysfunction： Advances and controversies

DOI: 10.12449/JCH240302

Borong YU,
Yuanwen CHEN^{,
,}

Department of Gastroenterology，Huadong Hospital Affiliated to Fudan University，Shanghai 200040，China

Research funding:

General Project of National Natural Science Foundation of China (82270620);

Project of Science and Technology Commission of Shanghai Municipality (22140901500)

More Information

Corresponding author: CHEN Yuanwen， chenywhdgi@fudan.edu.cn （ORCID： 0000-0003-4210-007X）
Received Date: 2023-11-21
Accepted Date: 2023-12-26
Published Date: 2024-03-20

Abstract

Abstract

Hepatitis B virus （HBV） is considered a “metabolic virus” that can influence a variety of metabolic processes. There is still a lack of definite conclusion on the association between chronic HBV infection and the various types of metabolic dysfunction， and little is known about the mechanism of the association of chronic HBV infection with the diseases characterized by metabolic disorder， such as metabolic syndrome， diabetes， and metabolic associated fatty liver disease. Currently it is believed that hepatitis B x gene （HBx）， derived from HBV genome， might play an important role in mediating systemic metabolic alterations after HBV infection， and HBx influences the metabolism of carbohydrates and lipids and causes metabolic dysfunction by retgulating the expression profiles of the key proteins such as PPARγ， C/EBPα， SREBP， and FATP2. Nonalcoholic fatty liver disease （NAFLD） is the most severe manifestation of metabolic dysfunction in the liver， and since both NAFLD and HBV infection can cause liver injury， the research on the interaction between them has attracted more and more attention， with controversies requiring further exploration. Therefore， this article elaborates on the research advances in chronic HBV infection and metabolic dysfunction， so as to provide ideas for subsequent studies.
- Hepatitis B Virus,
- Metabolic Syndrome,
- Non-alcoholic Fatty Liver Disease

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References

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