Association between the risk of increase in total cholesterol and the risk of cholelithiasis： A bidirectional Mendelian randomization study

Weiwei ZHAO; Xiaoxu DU; Hongyan GE

doi:10.12449/JCH240322

Volume 40 Issue 3

Mar. 2024

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > Journal of Clinical Hepatology > 2024 > 40(3): 573-580

PDF( 2528 KB)

Association between the risk of increase in total cholesterol and the risk of cholelithiasis： A bidirectional Mendelian randomization study

DOI: 10.12449/JCH240322

Weiwei ZHAO^{1, 2},
Xiaoxu DU¹,
Hongyan GE^{3
,
,
,}

1.
College of Clinical Medicine，Inner Mongolia Minzu University，Tongliao，Inner Mongolia 028000，China
2.
Tangfang Township Hospital，Xingping，Shaanxi 713100，China
3.
Medical College，Inner Mongolia Minzu University，Tongliao，Inner Mongolia 028000，China

More Information

Corresponding author: GE Hongyan， gehongyan_1999@126.com （ORCID： 0000-0003-3691-2805）
Received Date: 2023-06-23
Accepted Date: 2023-07-24
Published Date: 2024-03-20

Abstract

Abstract

Objective To investigate the association between the risk of increase in total cholesterol （TC） and the risk of cholelithiasis by using bidirectional Mendelian randomization （MR）. Methods The open gwas public database was used to obtain the single nucleotide polymorphism data associated with TC and cholelithiasis， and a secondary data analysis was performed for all summary data of genome-wide association studies. The genetic loci closely associated with TC or cholelithiasis were selected as exposure or outcome variables， and the bidirectional MR analysis was performed using the methods such as Egger regression， Weighted median， IVW random effects model， and IVW fixed effects model， with odds ratio （OR） values for evaluating the causal relationship between TC and cholelithiasis. Results With TC as the exposure and cholelithiasis as the outcome， TC-cholelithiasis had an overall OR value of 0.91 （95% confidence interval ［CI］： 0.85‍ ‍—‍ ‍0.97） before elimination of heterogeneity and 0.93 （95%CI： 0.89‍ ‍—‍ ‍0.97） after elimination of heterogeneity. With cholelithiasis as the exposure and TC as the outcome， TC-cholelithiasis had an overall OR value of 0.20 （95%CI： 0.06‍ ‍—‍ ‍0.65） before elimination of heterogeneity and 0.28 （95%CI： 0.10‍ ‍—‍ ‍0.83） after elimination of heterogeneity. There was a bidirectional causal relationship between genetically predicted TC and cholelithiasis. Conclusion This study confirms the bidirectional causal relationship between TC and cholelithiasis. The risk of cholelithiasis decreases with the increase in alleles associated with the elevation of TC level； on the contrary， the risk of elevated TC level decreases with the increase in alleles associated with the onset of cholelithiasis.
- Total Cholesterol,
- Cholelithiasis,
- Bidirectional Mendelian Randomization Analysis

FullText(HTML)

References(16)

References

[1]	GERMER CT. Cholelithiasis[J]. Chirurgie(Heidelb), 2022, 93( 6): 533- 534. DOI: 10.1007/s00104-022-01601-2.
[2]	CHEN L, YANG H, LI H, et al. Insights into modifiable risk factors of cholelithiasis: A Mendelian randomization study[J]. Hepatology, 2022, 75( 4): 785- 796. DOI: 10.1002/hep.32183.
[3]	ATAMANALP SS, KELES MS, ATAMANALP RS, et al. The effects of serum cholesterol, LDL, and HDL levels on gallstone cholesterol concentration[J]. Pak J Med Sci, 2013, 29( 1): 187- 190. DOI: 10.12669/pjms.291.2798.
[4]	KAWASHIRI MA, TADA H, NOMURA A, et al. Mendelian randomization: Its impact on cardiovascular disease[J]. J Cardiol, 2018, 72( 4): 307- 313. DOI: 10.1016/j.jjcc.2018.04.007.
[5]	PAPADIMITRIOU N, DIMOU N, TSILIDIS KK, et al. Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis[J]. Nat Commun, 2020, 11( 1): 597. DOI: 10.1038/s41467-020-14389-8.
[6]	BOWDEN J, DAVEY SMITH G, HAYCOCK PC, et al. Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator[J]. Genet Epidemiol, 2016, 40( 4): 304- 314. DOI: 10.1002/gepi.21965.
[7]	BOWDEN J, HOLMES MV. Meta-analysis and Mendelian randomization: A review[J]. Res Synth Methods, 2019, 10( 4): 486- 496. DOI: 10.1002/jrsm.1346.
[8]	SCHERBER PR, ZÚNIGA SE, GLANEMANN M, et al. Gallstone disease-interdisciplinary treatment[J]. Dtsch Med Wochenschr, 2020, 145( 5): 287- 295. DOI: 10.1055/a-0944-8655.
[9]	LAMMERT F, GURUSAMY K, KO CW, et al. Gallstones[J]. Nat Rev Dis Primers, 2016, 2: 16024. DOI: 10.1038/nrdp.2016.24.
[10]	LITTLEFIELD A, LENAHAN C. Cholelithiasis: Presentation and management[J]. J Midwifery Womens Health, 2019, 64( 3): 289- 297. DOI: 10.1111/jmwh.12959.
[11]	BURGESS S, THOMPSON SG. Interpreting findings from Mendelian randomization using the MR-Egger method[J]. Eur J Epidemiol, 2017, 32( 5): 377- 389. DOI: 10.1007/s10654-017-0255-x.
[12]	BOWDEN J, BURGESS S, DAVEY SG. Response to Hartwig and Davies[J]. Int J Epidemiol, 2016, 45( 5): 1679- 1680. DOI: 10.1093/ije/dyw252.
[13]	BIRNEY E. Mendelian randomization[J]. Cold Spring Harb Perspect Med, 2022, 12( 4): a041302. DOI: 10.1101/cshperspect.a041302.
[14]	BURGESS S, DAVEY SMITH G, DAVIES NM, et al. Guidelines for performing Mendelian randomization investigations: update for summer 2023[J]. Wellcome Open Res, 2019, 4: 186. DOI: 10.12688/wellcomeopenres.15555.3.
[15]	SUN H, WARREN J, YIP J, et al. Factors influencing gallstone formation: a review of the literature[J]. Biomolecules, 2022, 12( 4): 550. DOI: 10.3390/biom12040550.
[16]	REES J, WOOD AM, BURGESS S. Extending the MR-Egger method for multivariable Mendelian randomization to correct for both measured and unmeasured pleiotropy[J]. Stat Med, 2017, 36( 29): 4705- 4718. DOI: 10.1002/sim.7492.

Relative Articles

[1]	Shuyang ZHANG, Yanzhen BI, Shousheng LIU, Sheng LIU, Yongning XIN. Differentially expressed microRNAs in plasma exosomes from patients with chronic hepatitis B or hepatitis B virus-related acute-on-chronic liver failure: A bioinformatics analysis[J]. Journal of Clinical Hepatology, 2023, 39(8): 1848-1856. doi: 10.3969/j.issn.1001-5256.2023.08.013
[2]	Committee of Minimally Invasive Therapy in Oncology， Chinese Anti-Cancer Association, Committee of Ablation Therapy in Oncology， Chinese Anti-Cancer Association. Chinese expert consensus on Co-Ablation System for the treatment of primary liver cancer （2023 edition）[J]. Journal of Clinical Hepatology, 2023, 39(12): 2793-2797.
[3]	Yao ZHANG, Kai ZHANG, Pengdong KANG, Chao MA. Research advances in microRNA-200c in pancreatic cancer[J]. Journal of Clinical Hepatology, 2022, 38(4): 961-964. doi: 10.3969/j.issn.1001-5256.2022.04.045
[4]	Huijun XIE, Nasot Rashed, Yong NING, Chuan GAO. Current status of research on circulating microRNAs as diagnostic markers for hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2021, 37(2): 448-451. doi: 10.3969/j.issn.1001-5256.2021.02.042
[5]	Sheng CHEN, Guoxiang CHEN, Zhongming HE, Shujie CHENG, Jisen ZHAO. Role of miRNA in the development and progression of cholangiocarcinoma[J]. Journal of Clinical Hepatology, 2021, 37(9): 2241-2245. doi: 10.3969/j.issn.1001-5256.2021.09.048
[6]	Xuemei DING, Shilun WU, Wenbing SUN. Value of preoperative microRNA-192 in peripheral blood mononuclear cells in predicting microvascular invasion of solitary hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2021, 37(5): 1121-1125. doi: 10.3969/j.issn.1001-5256.2021.05.028
[7]	Xiuhong HUANG, Xiaoli XIE, Huiqing JIANG. Value of a microRNA risk score model in predicting the prognosis of hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2021, 37(5): 1110-1115. doi: 10.3969/j.issn.1001-5256.2021.05.026
[8]	Wu Jie, Li JingTao, Wei HaiLiang, Yan ShuGuang, Fan Yu, Guo YingJun, Chang ZhanJie. Advances in the role of microRNA in the intervention of malignant transformation of precancerous lesions of the liver by regulating the activation of hepatic stellate cells[J]. Journal of Clinical Hepatology, 2020, 36(7): 1650-1654. doi: 10.3969/j.issn.1001-5256.2020.07.045
[9]	Wu JunYi, Lai ZhiDe, Tian YiFeng, Wang YaoDong. Expression and clinical significance of serum exosomal microRNA-221-3p in hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2020, 36(8): 1768-1772. doi: 10.3969/j.issn.1001-5256.2020.08.018
[10]	Zhang ShiWan, Yu XueQin, Chen Fang, Mei YiHan, Mei XiaoPing. Biological characteristics of exosome microRNA and its role in the development and progression of liver fibrosis[J]. Journal of Clinical Hepatology, 2020, 36(9): 2083-2086. doi: 10.3969/j.issn.1001-5256.2020.09.039
[11]	Cheng YaFei, Wang Bin, Wang ShiMing. Role of microRNAs in gallbladder carcinoma[J]. Journal of Clinical Hepatology, 2020, 36(8): 1900-1904. doi: 10.3969/j.issn.1001-5256.2020.08.049
[12]	Wang ZhiXin, Gou Ping, Yu WenHao, Ren Li, Yang DanCaiRang, Wang HaiJiu, Fan HaiNing. Measurement and bioinformatics analysis of exosomes microRNAs in bile of hepatic alveolar echinococcosis patients with biliary tract invasion[J]. Journal of Clinical Hepatology, 2020, 36(9): 2045-2049. doi: 10.3969/j.issn.1001-5256.2020.09.027
[13]	Huang XiangJun, Zhang WenXing. Expression features and clinical significance of the microRNA-888 gene family in hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2019, 35(1): 119-122. doi: 10.3969/j.issn.1001-5256.2019.01.022
[14]	Niu YaQian, Chang YuLing, Liu Fang, Zhao Chuan, Chen Che. Regulatory role of microRNA in aerobic glycolysis in hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2019, 35(9): 2082-2084. doi: 10.3969/j.issn.1001-5256.2019.09.044
[15]	Zhang YuRui. Correlation between microRNA-520a and clinicopathological features of HBV-related hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2017, 33(4): 689-693. doi: 10.3969/j.issn.1001-5256.2017.04.018
[16]	Zhang ZhuQing, Lu ShuMing, Wang HuaLi, Xu MengYao, Li ChunYan, Xin Yue, Zhao JunJun. Expression of microRNA-222 in hepatocellular carcinoma tissue and its clinical significance[J]. Journal of Clinical Hepatology, 2017, 33(8): 1502-1505. doi: 10.3969/j.issn.1001-5256.2017.08.018
[17]	Wang DongXu, Huo TingTing, Tian YaoWen, Zhao Lei. Current status of research on microRNA associated with colorectal cancer liver metastasis[J]. Journal of Clinical Hepatology, 2016, 32(12): 2387-2390. doi: 10.3969/j.issn.1001-5256.2016.12.034
[18]	Li Qiang, Zhuo QiBin, Huang YuXian, Chen Liang. Diagnosis and treatment of hepatocellular carcinoma from a new perspective of miRNAs[J]. Journal of Clinical Hepatology, 2015, 31(6): 977-981. doi: 10.3969/j.issn.1001-5256.2015.06.037
[19]	Lin Kun, Ci DanWangJiu, Chang ZhiHui, Liu ZhaoYu. Clinical value of circulating micro RNAs in hepatic,biliary and pancreatic carcinomas[J]. Journal of Clinical Hepatology, 2015, 31(5): 790-795. doi: 10.3969/j.issn.1001-5256.2015.05.040
[20]	Qu YaChao, LYU Jun. Research progress in serum microRNA detection for diagnosis of hepatocellular carcinoma [J]. Journal of Clinical Hepatology, 2014, 30(3): 228-232. doi: 10.3969/j.issn.1001-5256.2014.03.008

Supplements(0)

Cited By

Cited by

Periodical cited type(2)

1.	张玉婷，李嘉泰，宋晓静，丁方回，岳平，闫少林，李俊峰，张立婷，李汛. 不同IgM水平的原发性胆汁性胆管炎患者治疗应答及预后特点分析. 胃肠病学和肝病学杂志. 2025(02): 250-253 .
2.	曹玫华，林欢. 泼尼松联合熊去氧胆酸对原发性胆汁性胆管炎合并自身免疫性肝炎的治疗效果. 深圳中西医结合杂志. 2024(19): 108-111 .

Other cited types(1)

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(6) / Tables(4)

Get Citation

PDF

XML

Article Metrics

Article views (751) PDF downloads(65)