Research advances in neutrophil extracellular traps and liver diseases

Zhuoga RENZENG; Kangjie YANG; Yongliang LU; Zhixin WANG; Haijiu WANG

doi:10.12449/JCH240334

Volume 40 Issue 3

Mar. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(3): 639-643

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Research advances in neutrophil extracellular traps and liver diseases

DOI: 10.12449/JCH240334

Zhuoga RENZENG^{1a, 2},
Kangjie YANG^1b,
Yongliang LU^1b,
Zhixin WANG^1a,
Haijiu WANG^{1a
,
,
,}

1a.
Department of Hepatobiliary Surgery，The Affiliated Hospital of Qinghai University，Qinghai 810001，China
1b.
Department of Clinical Laboratory，The Affiliated Hospital of Qinghai University，Qinghai 810001，China
2.
Department of Anesthesia，Lhasa People’s Hospital，Lhasa 850000，China

Research funding:

Qinghai Provincial Department of Science and Technology Clinical Medical Research Center Project (2017-SF-L2)

More Information

Corresponding author: WANG Haijiu， wanghaijiuqy@126.com （ORCID： 0000-0001-6033-238X）
Received Date: 2023-06-24
Accepted Date: 2023-07-10
Published Date: 2024-03-20

Abstract

Abstract

Neutrophils play an immune defense role by releasing the proteases such as neutrophil elastase and myeloperoxidase to form neutrophil extracellular trap （NET） and participate in the inflammatory response of various liver diseases， but the excessive release of NET may worsen liver tissue damage and has thus become one of the risk factors for liver diseases. In recent years， studies have shown that the excessive release of NET can promote the progression of liver diseases （such as viral hepatitis， nonalcoholic steatohepatitis， and hepatic ischemia-reperfusion injury） to liver cancer， and clarifying the mechanism of action of NET is of great importance for the diagnosis and progression of liver diseases. Therefore， this article elaborates on the latest research advances in NET in liver diseases， so as to provide new insights into the diagnosis and treatment of liver diseases and the prevention of liver cancer.
- Extracellular Traps,
- Liver Diseases,
- Liver Neoplasms

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References(31)

References

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Research advances in neutrophil extracellular traps and liver diseases

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