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Volume 40 Issue 3
Mar.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(3): 633-638

Role of mesenchymal stem cells and their exosomes in the treatment of drug-induced liver injury

DOI: 10.12449/JCH240333
  • 1.

    Department of Gastroenterology，The 940th Hospital of Joint Logistic Support Force of PLA，Lanzhou 730050，China

  • 2.

    Department of Gastroenterology，General Hospital of Ningxia Medical University，Yinchuan 750001，China

  • 3.

    Department of Gastroenterology，The Second Hospital of Lanzhou University，Lanzhou 730030，China

Research funding:

Gansu Province Health Care Industry Research Program (GSWSKY2023-34);

Special Projects for Graduate Student Supervisors of the 940th Hospital Youth (2023YXKY020);

Youth Formation Program of the 940th Hospital (2021yxky054);

Project of Excellent Youth Team Training for the Central Universities (31920220065);

Gansu Provincial Clinical Medical Research Center for Non-Infectious Liver Diseases (21JR7RA017)

More Information
  • Corresponding author: LU Lixia， 584778162@qq.com （ORCID： 0009-0003-4791-9049）; ZHANG Jiucong， zhangjiucong@163.com （ORCID： 0000-0003-4006-3033）
  • Received Date: 2023-08-07
  • Accepted Date: 2023-09-13
  • Published Date: 2024-03-20
    Abstract
  • The incidence rate of drug-induced liver injury （DILI） is increasing year by year with unknown mechanisms， and the treatment methods for DILI mainly include drugs， liver support systems， and liver transplantation， all of which have certain limitations. Therefore， the search for safer and more effective treatment methods has become a research hotspot at present. Studies have shown that mesenchymal stem cells and their exosomes can alleviate liver injury by reducing liver inflammation， promoting hepatocyte proliferation and regeneration， inhibiting the apoptosis of hepatocytes， improving oxidative stress， and regulating immunity. This article briefly reviews the role of mesenchymal stem cells and their exosomes in the treatment of DILI， so as to provide a reference for further research.

     

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