中文｜English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Menu
Issue 10
Oct.  2011
Turn off MathJax
Article Contents
Abstract
References
Article Navigation >  Journal of Clinical Hepatology  > 2011  >  27(10): 1106-1108

The advances of profibrogenic research of leptin and its signaling pathways in hepatic fibrosis

  • Published Date: 2011-10-20
    Abstract
  • Many kinds of chronic liver diseases can lead to hepatic fibrosis, which is the intermediate stage of liver cirrhosis.The activation of hepatic stellate cells plays a key role in the occurrence and development of liver fibrosis.Under the stimulation of inflammation, profibrogenic cytokines in the body activate their signaling pathways, so that the hepatic stellate cells change in morphology and function, causing collagen deposition.The leptin as a kind of profibrogenic cytokines, play an important role in the occurrence and development of hepatic fibrosis through its signal transduction mechanism.

     

    • FullText(HTML)
    • References(48)
  • [1]Friedman SL.Hepatic stellate cells:protean, multifunctional, and enigmatic cells of the liver[J].Physiol Rev, 2008, 88 (1) :125-172.
    [1]Friedman SL.Hepatic stellate cells:protean, multifunctional, and enigmatic cells of the liver[J].Physiol Rev, 2008, 88 (1) :125-172.
    [2]Bertolani C, Marra F.The role of adipokines in liver fibrosis[J].Pathophysiology, 2008, 15 (2) :91-101.
    [2]Bertolani C, Marra F.The role of adipokines in liver fibrosis[J].Pathophysiology, 2008, 15 (2) :91-101.
    [3]Marra F, Bertolani C.Adipokines in liver diseases[J].Hepa-tology, 2009, 50 (3) :957-969.
    [3]Marra F, Bertolani C.Adipokines in liver diseases[J].Hepa-tology, 2009, 50 (3) :957-969.
    [4]Potter JJ, Womack L, Mezey E, et al.Transdifferentiationof rat hepatic stellate cells results in leptin expression[J].Biochem Biophys Res Commun, 1998, 244 (1) :178-182.
    [4]Potter JJ, Womack L, Mezey E, et al.Transdifferentiationof rat hepatic stellate cells results in leptin expression[J].Biochem Biophys Res Commun, 1998, 244 (1) :178-182.
    [5]Ikejima K, Honda H, Yoshikawa M, et al.Leptin augmentsinflammatory and profibrogenic responses in the murine liverinduced by hepatotoxic chemicals[J].Hepatology, 2001, 34 (2) :288-297.
    [5]Ikejima K, Honda H, Yoshikawa M, et al.Leptin augmentsinflammatory and profibrogenic responses in the murine liverinduced by hepatotoxic chemicals[J].Hepatology, 2001, 34 (2) :288-297.
    [6]Qamar A, Sheikh SZ, Masud A, et al.In vitro and in vivoprotection of stellate cells from apoptosis by leptin[J].DigDis Sci, 2006, 51 (10) :1697-1705.
    [6]Qamar A, Sheikh SZ, Masud A, et al.In vitro and in vivoprotection of stellate cells from apoptosis by leptin[J].DigDis Sci, 2006, 51 (10) :1697-1705.
    [7]Wang J, Leclercq I, Brymora JM, et al.Kupffer cells medi-ate leptin-induced liver fibrosis[J].Gastroenterology, 2009, 137 (2) :713-723.
    [7]Wang J, Leclercq I, Brymora JM, et al.Kupffer cells medi-ate leptin-induced liver fibrosis[J].Gastroenterology, 2009, 137 (2) :713-723.
    [8]Zhan SS, Jiang JX, Wu J, et al.Phagocytosis of apoptoticbodies by hepatic stellate cells induces NADPH oxidase andis associated with liver fibrosis in vivo[J].Hepatology, 2006, 43 (3) :435-443.
    [8]Zhan SS, Jiang JX, Wu J, et al.Phagocytosis of apoptoticbodies by hepatic stellate cells induces NADPH oxidase andis associated with liver fibrosis in vivo[J].Hepatology, 2006, 43 (3) :435-443.
    [9]Jiang JX, Mikami K, Shah VH, et al.Leptin induces phago-cytosis of apoptotic bodies by hepatic stellate cells via a Rhoguanosine triphosphatase-dependent mechanism[J].Hep-atology, 2008, 48 (5) :1497-1505.
    [9]Jiang JX, Mikami K, Shah VH, et al.Leptin induces phago-cytosis of apoptotic bodies by hepatic stellate cells via a Rhoguanosine triphosphatase-dependent mechanism[J].Hep-atology, 2008, 48 (5) :1497-1505.
    [10]Manolakopoulos S, Bethanis S, Liapi C, et al.An assessmentof serum leptin levels in patients with chronic viral hepatitis:aprospective study[J].BMC Gastroenterol, 2007, 7 (1) :17.
    [10]Manolakopoulos S, Bethanis S, Liapi C, et al.An assessmentof serum leptin levels in patients with chronic viral hepatitis:aprospective study[J].BMC Gastroenterol, 2007, 7 (1) :17.
    [11]Ahima RS, Osei SY.Leptin signaling[J].Physiol behavior, 2004, 81 (2) :223-241.
    [11]Ahima RS, Osei SY.Leptin signaling[J].Physiol behavior, 2004, 81 (2) :223-241.
    [12]Cao Q, Mak KM, Lieber CS.Leptin enhances alphal (I) col-lagen gene expression in LX-2 human hepatic stellate cellsthrough JAK-mediated H2O2-dependent MAPK pathways[J].J Cell Biochem, 2006, 97 (1) :188-197.
    [12]Cao Q, Mak KM, Lieber CS.Leptin enhances alphal (I) col-lagen gene expression in LX-2 human hepatic stellate cellsthrough JAK-mediated H2O2-dependent MAPK pathways[J].J Cell Biochem, 2006, 97 (1) :188-197.
    [13]Cao Q, Mak KM, Ren C, et al.Leptin stimulates tissue in-hibitor of metalloproteinase-1 in human hepatic stellatecells:respective roles of the JAK/STAT and JAK-mediatedH2O2-dependant MAPK pathways[J].J Biol Chem, 2004, 279 (6) :4292-4304.
    [13]Cao Q, Mak KM, Ren C, et al.Leptin stimulates tissue in-hibitor of metalloproteinase-1 in human hepatic stellatecells:respective roles of the JAK/STAT and JAK-mediatedH2O2-dependant MAPK pathways[J].J Biol Chem, 2004, 279 (6) :4292-4304.
    [14]Cao Q, Mak KM, Lieber CS.Leptin represses matrix metal-loproteinase-1 gene expression in LX2 human hepatic stel-late cells[J].J Hepatol, 2007, 46 (1) :124-133.
    [14]Cao Q, Mak KM, Lieber CS.Leptin represses matrix metal-loproteinase-1 gene expression in LX2 human hepatic stel-late cells[J].J Hepatol, 2007, 46 (1) :124-133.
    [15]Niu L, Wang X, Li J, et al.Leptin stimulates alphal (I) colla-gen expression in human hepatic stellate cells via the phos-phatidylinositol 3-kinase/Akt signalling pathway[J].LiverInt, 2007, 27 (9) :1265-1272.
    [15]Niu L, Wang X, Li J, et al.Leptin stimulates alphal (I) colla-gen expression in human hepatic stellate cells via the phos-phatidylinositol 3-kinase/Akt signalling pathway[J].LiverInt, 2007, 27 (9) :1265-1272.
    [16]Zhou Y, Jia X, Wang G, et al.PI-3 K/AKT and ERK signa-ling pathways mediate leptin-induced inhibition of PPARgamma gene expression in primary rat hepatic stellate cells[J].Mol Cell Biochem, 2009, 325 (1) :131-139.
    [16]Zhou Y, Jia X, Wang G, et al.PI-3 K/AKT and ERK signa-ling pathways mediate leptin-induced inhibition of PPARgamma gene expression in primary rat hepatic stellate cells[J].Mol Cell Biochem, 2009, 325 (1) :131-139.
    [17]Choi SS, Syn WK, Karaca GF, et al.Leptin promotes themyofibroblastic phenotype in hepatic stellate cells by activa-ting the hedgehog pathway[J].J Biol Chem, 2010, 285 (47) :36551-36560.
    [17]Choi SS, Syn WK, Karaca GF, et al.Leptin promotes themyofibroblastic phenotype in hepatic stellate cells by activa-ting the hedgehog pathway[J].J Biol Chem, 2010, 285 (47) :36551-36560.
    [18]De Minicis S, Seki E, Oesterreicher C, et al.Reduced nicotin-amide adenine dinucleotide phosphate oxidase mediates fibroticand inflammatory effects of leptin on hepatic stellate cells[J].Hepatology, 2008, 48 (6) :2016-2026.
    [18]De Minicis S, Seki E, Oesterreicher C, et al.Reduced nicotin-amide adenine dinucleotide phosphate oxidase mediates fibroticand inflammatory effects of leptin on hepatic stellate cells[J].Hepatology, 2008, 48 (6) :2016-2026.
    [19]Tang Y, Chen A.Curcumin prevents leptin raising glucoselevels in hepatic stellate cells by blocking translocation of glu-cose transporter-4 and increasing glucokinase[J].Br JPharmacol, 2010, 161 (5) :1137-1149.
    [19]Tang Y, Chen A.Curcumin prevents leptin raising glucoselevels in hepatic stellate cells by blocking translocation of glu-cose transporter-4 and increasing glucokinase[J].Br JPharmacol, 2010, 161 (5) :1137-1149.
    [20]Li J, Si HF, LüX, et al.Suppressive effects of leflunomideon leptin-induced TIMP-1 production involves on hepaticstellate cell proliferation and apoptosis[J].Eur J Pharmacol, 2008, 580 (1-2) :63-69.
    [20]Li J, Si HF, LüX, et al.Suppressive effects of leflunomideon leptin-induced TIMP-1 production involves on hepaticstellate cell proliferation and apoptosis[J].Eur J Pharmacol, 2008, 580 (1-2) :63-69.
    [21]Elinav E, Ali M, Bruck R, et al.Competitive inhibition of lep-tin signaling results in amelioration of liver fibrosis throughmodulation of stellate cell function[J].Hepatology, 2009, 49 (1) :278-286.
    [21]Elinav E, Ali M, Bruck R, et al.Competitive inhibition of lep-tin signaling results in amelioration of liver fibrosis throughmodulation of stellate cell function[J].Hepatology, 2009, 49 (1) :278-286.
    [22]Cao Q, Mak KM, Lieber CS.DLPC and SAMe combined pre-vent leptin-stimulated TIMP-1 production in LX-2 human he-patic stellate cells by inhibiting HO-mediated signal transduc-tion[J].Liver Int, 2006, 26 (2) :221-223.
    [22]Cao Q, Mak KM, Lieber CS.DLPC and SAMe combined pre-vent leptin-stimulated TIMP-1 production in LX-2 human he-patic stellate cells by inhibiting HO-mediated signal transduc-tion[J].Liver Int, 2006, 26 (2) :221-223.
    [23]Handy JA, Saxena NK, Fu P, et al.Adiponectin activation ofAMPK disrupts leptin-mediated hepatic fibrosis via suppres-sors of cytokine signaling (SOCS-3) [J].J Cell Biochem, 2010, 110 (5) :1195-1207.
    [23]Handy JA, Saxena NK, Fu P, et al.Adiponectin activation ofAMPK disrupts leptin-mediated hepatic fibrosis via suppres-sors of cytokine signaling (SOCS-3) [J].J Cell Biochem, 2010, 110 (5) :1195-1207.
    [24]Friedman SL.Evolving challenges in hepatic fibrosis[J].NatRev Gastroenterol Hepatol, 2010, 7 (8) :425-436.
    [24]Friedman SL.Evolving challenges in hepatic fibrosis[J].NatRev Gastroenterol Hepatol, 2010, 7 (8) :425-436.
    • Relative Articles

  • Relative Articles

    [1]Deng YangYang, Ge ShanFei, Yu YanQing, Xiong Ying. Cell signaling pathways associated with liver fibrosis and potential therapeutic strategies[J]. Journal of Clinical Hepatology, 2020, 36(5): 1141-1145. doi: 10.3969/j.issn.1001-5256.2020.05.043
    [2]XU Zhen, LIU ShouSheng, TAN Jie, SUN BaoKai, DU ShuiXian, XIN YongNing, XUAN ShiYing. Expression and significance of leptin and adiponectin in serum of patients with nonalcoholic fatty liver disease and coronary heart disease[J]. Journal of Clinical Hepatology, 2020, 36(11): 2478-2483. doi: 10.3969/j.issn.1001-5256.2020.11.016
    [3]Peng Qin, Zhao ShenJun, Li Wu. Research advances in signaling pathways involved in the development of hepatic fibrosis[J]. Journal of Clinical Hepatology, 2017, 33(5): 954-958. doi: 10.3969/j.issn.1001-5256.2017.05.035
    [4]Ren ChangZhen, Hao LiSen. Signal transduction involved in activation of hepatic stellate cells[J]. Journal of Clinical Hepatology, 2015, 31(3): 452-456. doi: 10.3969/j.issn.1001-5256.2015.03.034
    [5]Wang CuiHua, Yue Yan. Research progress in relationship of leptin and adiponectin with non-alcoholic fatty liver disease[J]. Journal of Clinical Hepatology, 2015, 31(8): 1351-1354. doi: 10.3969/j.issn.1001-5256.2015.08.045
    [6]Pan Jin, Ju Jian. Current perspectives on the JAK/STAT signaling pathway and its activating factors in liver fibrosis[J]. Journal of Clinical Hepatology, 2013, 29(5): 393-396.
    [7]Li JunFeng, Deng YongDong, Zhang LiTing, Chen Hong. The role of Ras/ERK signal transduction pathway in the occurrence and development of hepatic fibrosis[J]. Journal of Clinical Hepatology, 2011, 27(3): 325-327.
    [8]Kong Yin, Zhang LingYi. The role of leptin and adiponectin in non-alcoholic fatty liver disease[J]. Journal of Clinical Hepatology, 2011, 27(4): 441-443.
    [9]Liu ChengYi, Chen YanDong. Measurement of serum leptin level in acute pancreatitis patients[J]. Journal of Clinical Hepatology, 2009, 25(6): 437-439.
    [10]Wang ChunPing, Zhang Ming. Evaluation of leptin receptor Gln223Arg polymorphism in patients with non-alcoholic fatty liver disease[J]. Journal of Clinical Hepatology, 2008, 24(3): 194-196.
    [11]Li YuQin, Po YunFeng, Chen ZhaoJie, Ding BaiJing, Tang TongYu, Wang Dan, Gao YanHang, Jin JingLan. Relationship between the levels of serum leptin and insulin resistance in patients with fatty liver[J]. Journal of Clinical Hepatology, 2007, 23(5): 360-361.
    [12]Li RuiYan, Xiong JinHu. Evaluation of the clinical value of the concentration of leptin in viral hepatitis[J]. Journal of Clinical Hepatology, 2007, 23(2): 96-97.
    [14]Liu FengHai, Sun LinYu, Tan HaiYan, Liu XiaoLi. The clinical significance of serum leptin levels in patients with nonalcoholic fatty liver[J]. Journal of Clinical Hepatology, 2006, 22(1): 41-42.
    [15]Lu ZhenYa, Wang QunYan, Rao WeiQiang, Cai WeiMin. Relationship between leptin resistance and nonalcoholic fatty liver in male patients.[J]. Journal of Clinical Hepatology, 2006, 22(1): 39-41.
    [16]Zheng JiMin, Jiang HuiQing, Lu: XiaoPing, Zhang XiangMei. Measurement of ghrelin leptin levels in patients with liver cirrhosis[J]. Journal of Clinical Hepatology, 2006, 22(3): 195-196.
    [17]Lu ZhenYa, Wang QunYan, Rao WeiQiang, Cai WeiMin, Liu RongHua. The relationship between serum leptin levels and the levels of fibrosis marks in patients with hepatitis B.[J]. Journal of Clinical Hepatology, 2004, 20(2): 85-86.
    [18]Zhao CaiYan, Liu JingWen, Liang BaoLi, Li JianMei. Relationship between serum leptin and liver fibrosis in patients with alcoholic liver disease[J]. Journal of Clinical Hepatology, 2004, 20(6): 348-350.
    • Supplements(0)
    • Cited By
  • Created with Highcharts 5.0.7Amount of accessChart context menuAbstract Views, HTML Views, PDF Downloads StatisticsAbstract ViewsHTML ViewsPDF Downloads2024-042024-052024-062024-072024-082024-092024-102024-112024-122025-012025-022025-03051015
    Created with Highcharts 5.0.7Chart context menuAccess Class DistributionFULLTEXT: 5.1 %FULLTEXT: 5.1 %META: 91.3 %META: 91.3 %PDF: 3.6 %PDF: 3.6 %FULLTEXTMETAPDF
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 2.5 %其他: 2.5 %[]: 1.5 %[]: 1.5 %上海: 1.8 %上海: 1.8 %北京: 12.4 %北京: 12.4 %南宁: 0.4 %南宁: 0.4 %吉林: 0.7 %吉林: 0.7 %呼和浩特: 0.4 %呼和浩特: 0.4 %广州: 0.7 %广州: 0.7 %张家口: 2.9 %张家口: 2.9 %本溪: 0.7 %本溪: 0.7 %杭州: 0.4 %杭州: 0.4 %武汉: 0.7 %武汉: 0.7 %石家庄: 0.4 %石家庄: 0.4 %芒廷维尤: 34.9 %芒廷维尤: 34.9 %莫斯科: 0.7 %莫斯科: 0.7 %西宁: 37.5 %西宁: 37.5 %长春: 1.5 %长春: 1.5 %其他[]上海北京南宁吉林呼和浩特广州张家口本溪杭州武汉石家庄芒廷维尤莫斯科西宁长春

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索
    Get Citation
    PDF
    XML

    Article Metrics

    Article views (3552) PDF downloads(740) Cited by()
    Proportional views
    Related
        

    The first journal specializing in hepatobiliary and pancreatic diseases in China

    Supervisor：Ministry of Education of the People's Republic of China

    Sponsor：Jilin University

    Academic Support: Chinese Society of Hepatology，Chinese Medical Association

    Address: 461 Xinjiang Road, Changchun

    Submit：0431-88782044

    Peer review：0431-88783542

    Email：lcgdb@vip.163.com

    About Journal

    Submission Guideline

    Journal Online

    Hepatobiliary College

    Guidelines

    YesterdayIP[2482]YesterdayPV[4685]TodayIP[325]TodayPV[558]Online[34]

    Website Design © 2020 Editorial Board of Journal of Clinical Hepatology 吉ICP备10000617号-1 Supported by: Beijing Renhe Information Technology Co. Ltd  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return