Relationship between the genotypes of hepatitis B virus and the expression of HBeAg and its clinical significance

Wang LiPing; Han FangZheng; Wu GuangHui

Issue 5

May 2011

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Relationship between the genotypes of hepatitis B virus and the expression of HBeAg and its clinical significance

Published Date: 2011-05-20

Abstract

Abstract

Objective To investigate the relationship between different genotypes of hepatitis B virus (HBV) and the expression of HBeAg and the severity of liver diseases.Methods The HBV genotypes were determined by multiple-primer PCR amplification and the HBV DNA levels were detected by fluorescent quantitative PCR assay.Results In 120 HBV infected cases, 84 cases (70%) were genotype C, 31 cases (25.8%) were genotype B and 5 cases (4.2%) were mixed genotype BC;genotypes A, D, E, F were not detected.More patients were HBeAg-positive than were HBeAg-negative in Genotype C (P<0.05) .There was no significant difference between the HBeAg negative and HBeAg positive in genotyoe B.Conclusion This study suggests that genotype B and C are predominant genotype in Xuzhou area.The HBeAg positive expression is predominant in genotype C.Compare to the patients with genotype B, more severe inflammation was observed in patients with genotype C.
- hepatitis B virus,
- hepatitis B e antigens,
- genotype,
- gene expression

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沈阳化工大学材料科学与工程学院沈阳 110142

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Relationship between the genotypes of hepatitis B virus and the expression of HBeAg and its clinical significance

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