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Jun.  2012
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Article Navigation >  Journal of Clinical Hepatology  > 2012  >  28(6): 428-430

Distribution of HBV genotypes and YMDD mutations in E antigen-positive patients

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  • Published Date: 2012-06-20
    Abstract
  • Objective To investigate the distribution of hepatitis B virus (HBV) genotypes and determine the correlation with YMDD mutations present in those HBV genomes.Methods One-hundred-and-thirty-seven patients with chronic HBV infections and HBV e antigen (HBeAg) -positivity were recruited for study between February 2008 and January 2009.HBV genotypes were detected by real-time PCR, and YMDD mutations were detected by ligase detection reaction (LDR) .Results Twenty-one of the 137 specimens were unsuccessful in genotyping.For the remaining 116 specimens, two (1.7%) were genotype A, 19 (16.4%) were genotype B, 91 (78.5%) were genotype C, and four (3.5%) were genotype D.YMDD mutations were detected in 41 (35.4%) of the specimens, including seven (36.8%) of genotype B, 33 (36.3%) of genotype C, and one (25.0%) of genotype D.Mutation rates were higher in genotypes B and C than in genotype D, but the differences did not reach statistical significance (χ2=0.034, P>0.05) .Among the 41 viruses carrying the YMDD mutation, 60.9% were classified as I mutation, 31.7% as V mutation, and 7.4% as I/V mixed mutation.Conclusion The most frequent HBV genotype in our hospital's chronic HBV population is genotype C, followed by genotype B.The YMDD mutation rates in genotypes B and C were similar, and the mutation rate was not correlated with the genotype.

     

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  • [1]Okamoto H, Tsuda F, Sakugawa H, et al.Typing hepatitis B virusby homology in nudeotide sequence:comparison of surface antigensubtypes[J].Gen Virol, 1988, 69 (10) :2575-2583.
    [2]Norder H, Hammas B, Lofdal S, et al.Camparison of the aminoacid sequence of nine different.Senotypes of hepatitis B surface an-tigen and genamic classification of the corresponding hepatitis B vi-rus strain[J].Gen Virol, 1992, 72 (pt5) :1201-1208.
    [3]Lindh M, Gonzalez JE, Norkmus G, et al.Genotyping of hepatitis Bvirus by restriction patteno analysis of a pre-samplicon[J].J Virolmetnods, 1998, 72 (2) :163-174.
    [4]任来峰, 申元英.乙型肝炎病毒基因型分型方法研究进展[J].国际病毒学杂志, 2006, 2 (13) :26-29.
    [5]Zeng G, Wang Z, Wen S, et al.Geographic distribution, virologicand clinical characteristics of hepatitis B virus genotypes in China[J].Viral Hepat, 2005, 12 (6) :609-617.
    [6]秦华, 吴晓庆.兰州地区HBV基因型的分布及临床意义[J], 临床肝胆病杂志, 2010, 26 (3) :295-296.
    [7]李天一, 陈青锋, 肖萍, 等.兰州地区乙肝病毒基因亚型的感染情况[J], 临床消化病杂志, 2002, 14 (3) :99-100.
    [8]Akuta N, Kumada H.Influence of hepatitis B virus genotypes onthe response to antiviral therapies[J].J Antimicrob Chemother, 2005, 55 (2) :139-142.
    [9]朱冰, 骆抗先, 胡族琼, 等.乙型肝炎病毒基因型分型方法的建立及应用[J].中华实验和临床病毒学杂志, 1999, 13 (4) :309.
    [10] 中华医学会肝病学分会与中华医学会传染病学分会.慢性乙型肝炎防治指南[J].中华肝脏病杂志, 2005, 13 (12) :889-891.
    [11]Di Marco V, Marzano A, Lampertico P, et al.Clinical outcome ofHBeAg-negative chronic hepatitis B in relation to virological re-sponse to lam ivudine[J].Hepatology, 2004, 40 (4) :883-891.
    [12]Keeffe EB, Dieterich DT, Han SH, et al.A treatment algorithm forthe management of chronic hepatitis B virus infection in the UnitedStates:an update[J].Clin Gastroenterol Hepatol, 2006, 4 (8) :936-962.
    [13]Lok AS, McMahon BJ.Chronic hepatitis B[J].Hepatology, 2007, 45 (2) :507-539.
    [14]刘映霞, 位兴辉, 罗志雄, 等.乙型肝炎患者HBV基因型与核苷 (酸) 类似物耐药变异的关系[J].中华实验和临床感染病杂志, 2007, 1 (2) :86-91.
    [15]马亚平, 曹红, 李俊枫.乙型肝炎病毒基因型、YMDD变异与病毒复制水平的关系[J].国际检验医学杂志, 2011, 32 (3) :400-401.
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