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Article Navigation >  Journal of Clinical Hepatology  > 2011  >  27(1): 61-64

Prediction of HLA-DRB1*0311/0401 in recognizing epitopes of HCV Core protein of different genotypes

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  • Published Date: 2011-01-20
    Abstract

  • Objective To predict the epitopes of hepatitis C virus (HCV) core protein of different genotypes, which can be recognized by HLA-DRB1*0311/0401.Methods Ten complete amino acid sequences of HCV were searched from NCBI database, which contain six genotypes of HCV.Core sequences were selected to predict secondary structure, flexiblity, hydrophilicity, antigen index and then predict the HLA-DRB1*0311/0401 in recognizing epitopes.Results The probable regions of epitopes according to the secondary structure, flexiblity, hydrophilcity and antigen index of HCV core protein were 16-28, 60-74 and 98-120 respectively.For HLA-DRB1*0311, the highest scoring region in 1a/1b, 4a, 6a was 28-36, 2a/b was 63-71, 3a was 29-37 and 5a was 94-102.For HLA-DRB1*0401, the highest scoring region in 1a, 2b, 4a, 6a was 84-92, 5a was 120-128, 1b was 120-128 with low score.Conclusion There were different epitopes of HCV Core protein recognized by HLA-Ⅱ between the different HCV genotypes.

     

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