慢性乙型肝炎病毒基因型与干扰素治疗应答的关系

To observe the relationship between HBV genotypes of chronic hepatitis B and efficacy of interferon-α therapy. A simplified RFLP method was established with AvaⅡ and DpnⅡ at amplified segment of the pre-S of HBV DNA. The method was applied to 60 serum samples from patients with chronic hepatitis B on IFN-α therapy. The genotype B was detected in 51 7% (31/60) . The difference was not significant in responsive rate to IFN-α therapy between genotype B and genotype C ( P >0 05) . Three patients of genotype D are effective on therapy. The Genotypes B and Genoltypes C are prevalent in a majority of area in our country. HBV genotypes might not be an important predictive factor in determining the efficacy of IFN-α therapy. The study indicates Genotype D is higher in responsive rate to IFN-α therapy.