Distribution of hepatitis B virus genotype in Xuzhou and its clinical significance

Liu ChengYong; Hou YuanPei; Qian XiuMei; Sun Qing; Song Li

Issue 3

Mar. 2005

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > Journal of Clinical Hepatology > 2005 > 21(3): 151-152

PDF( 118 KB)

徐州地区乙型肝炎病毒基因型分布及其意义

Published Date: 2005-03-20

Abstract

Abstract

To study the distribution of hepatitis B virus genotype in Xuzhou and clarify the genotype-related diffrence in the liver function and level of HBV DNA.HBV genotype was determined by PCR-Microplate sandwich hybridization-ELISA technique.Analysed the clinical significance combining with the value of HBV DNA and ALT.Among them genotype B was 26.7%, genotype C was 44.0%, genotype D was 17.3%.The HBV DNA value of genotype C was significantly higher than that of genotype B in AH, CHB, and HLC, (t=2.45, 2.53 and 2.36, P=0.027, 0.018 and 0.029) , genotype D and genotype which related to geonotybe D is 57.1% in fulminiant hepatic failure (FHF) , genotype C is the major genotype in Xuzhou and associated with the development of severe liver disease contrarying with genotype B, genotype D perhaps related with fulminiant hepatic failure.
- Hepatitis B virus,
- Genotype,
- HBV DNA

FullText(HTML)

References(8)

References

[1]许军, 王齐欣, 蒋栋, 等.乙肝病毒基因型与病情轻重的关系[J].中华肝脏病杂志, 2003, 11 (1) ∶11-13.

[2]王永忠, 周国平, 李夏亭, 等.乙型肝炎病毒基因分型及临床应用研究[J].中华实验和临床病毒学杂志, 2002, 16 (4) ∶367-369.

[3] 中华医学会.病毒型肝炎防治方案[J].传染病信息, 2000, 13∶141-150.

[4]王虹, 万成松, 王省良, 等.采用PCR微板杂交-ELISA技术进行HBVDNA基因分型的研究[J].中华微生物和免疫学杂志, 2001, 21 (2) ∶234-236.

[5]刘映霞, 胡国龄, 谭德明.湖南省乙肝病毒基因型分布及临床意义[J].湖南医科大学学报, 2002, 27 (1) ∶29-31.

[6]李天一, 陈青锋, 肖萍, 等.兰州地区乙肝病毒基因亚型的感染情况[J].临床消化杂志, 2002, 14 (3) ∶99-100.

[7]许红梅.乙型肝炎病毒基因型的分子生物学及临床意义[J].国外医学·流行病学与传染病学分册, 2003, 30 (1) ∶20-22.

[8]KaoJH, ChenPJ, LaiMY, etal.Clinicalandvirologicalaspectsofblood donorsinfectedwithhepatitisBvirusgenotypesBandC[J].JClinMi crobiol, 2002, 40 (1) ∶22-25.

Relative Articles

[1]	Liangying GAN, Li ZUO. Micro-elimination of hepatitis C virus infection in the hemodialysis population[J]. Journal of Clinical Hepatology, 2024, 40(4): 659-664. doi: 10.12449/JCH240403
[2]	Yu WANG, Wenge XING, Zhongfu LIU, Cong JIN. Advances in laboratory testing methods and strategies for hepatitis C virus infection[J]. Journal of Clinical Hepatology, 2024, 40(4): 672-678. doi: 10.12449/JCH240405
[3]	Li ZHANG, Peng HU. Hepatitis C virus infection and organ transplantation[J]. Journal of Clinical Hepatology, 2024, 40(4): 665-671. doi: 10.12449/JCH240404
[4]	Peng MiLin, Xiao XinQiang, Jiang YongFang, Tian Yi, Xu Yun, Zhang Min, Wang WenLong, Peng Feng, Gong GuoZhong. Preliminary study on effect of hepatitis C virus nonstructural protein 5A on HIV LTR[J]. Journal of Clinical Hepatology, 2014, 30(2): 136-140. doi: 10.3969/j.issn.1001-5256.2014.02.010
[5]	Zhu FuSheng, Qin YuJie, Cheng ZhenJiang, Jiang PeiRong, Zhang LingHui. The impact of HBV/HCV coinfection on HBV DNA levels and the severity of liver diseases in HBV-infected patients undergoing hemodialysis[J]. Journal of Clinical Hepatology, 2013, 29(2): 136-137+141.
[6]	Wang YuMing, Cheng Lin. Recent perspectives of Chinese medicine-based therapy for hepatitis B and C virus infection[J]. Journal of Clinical Hepatology, 2012, 28(11): 872-876.
[7]	Nie HongMing, Chen JianJie, Dong HuiLin, Yang YuQi, Wang ChengBao, Li HongDing, Chen YiYun, Gao YueQiu. Analysis of clinical characteristics of the infection of HCV genotype 1 and non-genotype 1 in China[J]. Journal of Clinical Hepatology, 2012, 28(6): 439-442.
[8]	Wang Yu, Zhang Ying, Jia ZhanSheng. Recent treatment advances for hepatitis C virus-related mixed cryoglobulinemia[J]. Journal of Clinical Hepatology, 2012, 28(8): 628-632.
[9]	Yin Xiao, Wen Bo, Tan WenJie. Progress in the development and immunogenicity improvement of DNA vaccine against chronic HCV infection[J]. Journal of Clinical Hepatology, 2011, 27(1): 32-35.
[10]	Tian Di, Xu XiaoYuan. Treatment of hepatitis C virus infection in HIV/HCV co-infected patients[J]. Journal of Clinical Hepatology, 2011, 27(5): 540-544.
[11]	Gao LuHua, Nie QingHe. Detection of hepatitis C virus in the supernatant of human placenta trophoblastic cells and cell lysates[J]. Journal of Clinical Hepatology, 2011, 27(12): 1296-1300.
[12]	Lou GuoHua, Liu YanNing, Yin ChunBen, Chen Feng, Jia ZhanSheng, Chen Zhi. Preliminary study of HCV mouse model induced by infectious HCV 2a plasmid[J]. Journal of Clinical Hepatology, 2011, 27(1): 72-75.
[13]	Yan Yan, Xiu BingShui, Yin JiMing, Zhang HeQiu, Li Zhuo. Evaluation of cross-reactive antibody response to hypervariable region 1 of hepatitis C virus[J]. Journal of Clinical Hepatology, 2011, 27(8): 818-820.
[14]	Qi ZhongTian. Hepatitis C virus infection and its therapeutic drugs[J]. Journal of Clinical Hepatology, 2011, 27(1): 15-18+27.
[15]	Yang RuiFeng, Wei Lai. Detection of hepatitis C virus infection[J]. Journal of Clinical Hepatology, 2011, 27(1): 1-7.
[16]	Jiang XiaoHua, Liu LingLing, Lei Chuang, Zhou QingPing. Effects of hepatitis C virus genotype 1b core protein on the gene expressions of Bax and Bcl-2 in HepG2 cells[J]. Journal of Clinical Hepatology, 2011, 27(5): 511-514.
[17]	Sun MengNing, Lan HaiYun, Ma Yu, Zhao Ya, Lu: Xin, Yang Jing, Lei YingFeng, Yao Min, Kang Jian, Zhao MingGao, Wang AiQin, Yin Wen. Generation of conditionally controlled transgenic mice expressing hepatitis C virus NS3/4A protease[J]. Journal of Clinical Hepatology, 2011, 27(1): 76-80.
[18]	Cheng Ling, Hong GuoHu, Guo Yan, Mao Qing. Prediction of HLA-DRB1*0311/0401 in recognizing epitopes of HCV Core protein of different genotypes[J]. Journal of Clinical Hepatology, 2011, 27(1): 61-64.
[19]	Wen Ming, Xiao XinQiang, Gong GuoZhong. Hepatitis C virus NS5A protein stimulates TLR4 expression[J]. Journal of Clinical Hepatology, 2011, 27(1): 49-52.
[20]	Chen LiDong, Cheng Jun, Hong Yuan, Zhang LianFeng, Han Li, Guo Jiang. Construction of the prokaryotic expression vector of NS5ATP4A gene and its expression[J]. Journal of Clinical Hepatology, 2010, 26(4): 371-373.

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views (2301) PDF downloads(741)

徐州地区乙型肝炎病毒基因型分布及其意义

Abstract

References

Relative Articles

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

徐州地区乙型肝炎病毒基因型分布及其意义

Abstract

References

Relative Articles

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

About Journal

Submission Guideline

Journal Online

Hepatobiliary College

Guidelines

Export File

Citation

Format

Content