The levels of TNF-α, sIL-2R and VEGF in patients with primary hepatic carcinoma after double intra-arterial infusion of anti-cancerous agents

Objective To study the therapeutic efficacy of transcatheter arterial chemoembolization combined with lienalis infusion in primary hepatocellular carcinoma (HCC) and its relation with the serum levels of TNF-α, sIL-2R and VEGF.Methods A total of 45 patients were included in a transcatheter arterial chemoembolization combined with lienalis infusion therapy to portal vein indirectly.The serum levels of TNF-α, sIL-2R and VEGF and the disease prognosis were analyzed.Results The post-treatment serum level of TNF-α, sIL-2R and VEGF in HCC patients were lower than the pre-treatment level (P<0.01) .There was no significant difference in prognosis between patients who had been treated for 2 years and more than two years.The survival rates for 1, 2, 3 and 4 years of treatment were 71.1%, 51.1%, 24.4% and 8.9%, respectively.Conclusion Double intra-arterial infusion of anti-cancerous agents reduce the serum levels of serum TNF-α, sIL-2R and VEGF in HCC patients and improves prognosis.