TNF α and TGF β1 in the serum of patients with primary hepatic cancer before and after transcatheter arterial chemoembolization

Lu ZhongHua; Deng Jun; Yang XiaoJuan; Pei Hao; Zhuang LinNi; Chen Wei

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Jun. 2009

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Article Navigation > Journal of Clinical Hepatology > 2009 > 25(6): 435-436

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原发性肝癌患者肝动脉化疗栓塞术前后血清TNFα、TGFβ1浓度变化及意义探讨

Published Date: 2009-06-20

Abstract

Abstract

Objective To observe the change in the serum level of tumor necrosis factor alpha (TNF α) and transformation growth factor beta (TGF β1) in patients with primary hepatic carcinoma before and after the treatment with transcatheter hepatic arterial chemoembolization (TACE) Methods 30 primary hepatic cancer patients were randomly selected.The levels of TNF α and TGF β1 were measured by enzyme linked immune sorbent assay (ELISA) before and after treatment.Results the levels of TNF α and TGF β1 were decreased significantly after two weeks of treatment (p<0.01) .Conclusion Measurement of the levels TNF α and TGF β1 might have a significant clinical importance in the prognosis of primary hepatic carcinoma during TACE treatment.
- Primary hepatic cancer,
- Hranscatheter hepatic arterial chemoembolization,
- Tumor necrosis factor α,
- Transformation growth factor β1

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[1]李欣, 冯敢生, 郑传胜, 等.肝动脉化疗栓塞对肿瘤血管生成影响的实验研究[J].中华放射学杂志, 2002, 36 (8) ∶689-693.

[2]Poon RT, Lau CP, Yu WC, et al.High serum levels of vascular en-dothelial growth factor predict poor response to transarterial chemoem-bolization in hepatocellular carcinoma a prospective study[J].Oncol Rep, 2004, 11 (5) ∶1077-1084.

[3]Kuo NT, Benhayon D, Przybylski RJ, et al.Prolonged hypoxia in-creases vascular endothelial growth factor mRNA and protein in adult mouse brain[J].J Appl Physiol, 1999, 86 (1) ∶260-264.

[4]孙惠川, 汤钊猷, 王鲁, 等.肝癌患者血清VEGF、sVCAM和bFGF浓度的研究与术后短期复发的相关性[J].肿瘤, 2001, 21 (6) ∶455-457.

[5]Imura S, Miyake H, Izumi K, et al.Corralation of vascular endothe-lia cell proliferation with microvessel density and expression of vascu-lar endothelial growth factor and basic fibroblast growth factor in hep-atocellular carcinoma[J].J Med Invest, 2004, 51 (3-4) ∶202-209.

[6]Zhou J, Tang ZY, Fan J, et al.Expression of platelet-derived en-dothelial cell growth factor and vascular endothelial growth factor in hepatocellular carcinoma and portal vein tumor thrombus[J].J Cancer Res Clin Oncol, 2000, 126 (1) ∶56-61.

[7]Mathonnet M, Descottes B, ValleixD, et al.Quantitative analysis u-sing ELISA of vascular endothelial growth factor and basic fibroblast growth factor in human colorectal cancer, liver metastasis of colorec-tal cancer and hepatocellular carcinoma[J].World J Gastroenterol, 2006, 12 (23) ∶3782-3783.

[8]Ji GZ, Wang XH, Miao L, et al.Role of transforming growth facter-betal-smad signal transduction pathway in patients with hepatocellu-lar carcinoma[J].World J Gastroenterol, 2006, 12 (4) ∶644-648.

[9]刘谨文, 易继林.经肝动脉化疗栓塞后TGFβ1、TGFα在肝癌细胞凋亡中的作用[J].临床外科杂志, 2000, 8 (6) ∶352-353.

[10]Sanchez-Elsner T, Botella LM, Velasco B, et al.Synergistic co-operation between hypoxia and transforming growth factor-βpath-ways on human vascular endothelial growth factor gene expression[J].J Biol Chem, 2001, 276 (42) ∶38527-38535.

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原发性肝癌患者肝动脉化疗栓塞术前后血清TNFα、TGFβ1浓度变化及意义探讨

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原发性肝癌患者肝动脉化疗栓塞术前后血清TNFα、TGFβ1浓度变化及意义探讨

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