The expression of apoptosis by TNF-α, TNFR and Bcl-2 family in chronic liver disease

Chen NaiLing; Deng Tao; Bai Ling; Zhang Chang; Chen PeiLan; Li Lin; Chen Hao

Issue 6

Jun. 2002

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Article Navigation > Journal of Clinical Hepatology > 2002 > 18(6): 342-343

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慢性肝病肝组织凋亡蛋白TNF-α、TNFR、Bcl-2家族表达的研究

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Published Date: 2002-06-20

Abstract

Abstract

To study the expression of TNF-α?TNFR and Bcl-2 family in patients with chronic hepatitis?liver cirrhosis and hepatocellular carcinoma. The apoptosis family in the liver tissue was studied by Nucleic acid molecular hybrodisation or immunohistochemistry. In 94 cases of TNFR in the liver cirrhosis group were significantly higher than that in chronic hepatitis and hepatocellular carcinoma group ( P <0 01) . The greater of expression level of TNF-α?TNFR and Fas in higher HAI. On the contrary, The lower of expression level of Bcl-2. It is suggested that TNF-α?TNFR and Bcl-2 famlily is involved in the regulation of apoptosis in the chronic liver diseases.
- Apoptosis,
- Hepatitis,
- liver cirrhosis,
- hepatocellular carcinoma,

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慢性肝病肝组织凋亡蛋白TNF-α、TNFR、Bcl-2家族表达的研究

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慢性肝病肝组织凋亡蛋白TNF-α、TNFR、Bcl-2家族表达的研究

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