C-myc基因和P16基因在肝细胞癌中的表达及其临床意义

Objective To approach the clinical significance of C-myc and P16 gene's expression in hepatocellular carcinoma (HCC) .Methods C-myc and P16 gene's expression in HCC tissue and cancer adjacent liver tissue and normal liver tissue were detected by immunohistochemistry.Results The expression of C-myc in HCC tissue was higher than that in cancer adjacent liver tissue and normal liver tissue (P<0.05) .The expression of C-myc had no association with the patients'age, sex, the size of tumor and UICC stage (P>0.05) .It had some association with the patients'age, sex, the size of tumor (P>0.05) .The expression of P16 had some association with the UICC stage and the metastasis of HCC (P<0.05) .Conclusion The enhancement of expression of C-myc and the disorder of expression of P16 could promote the occurrence and development of HCC and could be used as prognostic factors.