Detection and clinical characteristics analysis of occult hepatitis B virus infection

Wang Xia; Chen ChangYun; Zhang JiaJun; Shi Jun; Zhu XinYu; Wang Yan; Wu JianRui

Issue 4

Apr. 2007

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Article Navigation > Journal of Clinical Hepatology > 2007 > 23(4): 243-245

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隐匿性乙型肝炎病毒感染的检测及临床特点分析

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Published Date: 2007-04-20

Abstract

Abstract

To investigate the detection of occult hepatitis B virus infection among liver diseases of unknown etiology using nested polymerase chain reaction method;to analyze the clinic characteristics of HBV occult infection.104 patients with liver disease of unknown etiology were enrolled in this study.To design and compare the efficacy of different sets of nested primers which were located at s gene, x gene an c gene of HBV genome respectively.Select the primers which were more efficiency to detect occult HBV infection.To analysis the clinical, biochemical features between HBV DNA positive cryptogenic hepatitis and HBV DNA negative cryptogenic hepatitis, 13 cases were detected being infected with HBV.Patients of occult hepatitis infection were significantly older than patients in whom the HBV DNA were negative;meanwhile, the proportion of the decompensated cirrhosis in the former is more than that of in the latter.Occult HBV infections may account for a proportion of liver diseases of "unknown" etiology.Low serum level of HBV DNA may cause disease progression, even hepatocirrhosis.
- hepatitis B virus,
- cryptogenic hepatitis,
- occult HBV infection,
- hepatocirrhosis

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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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隐匿性乙型肝炎病毒感染的检测及临床特点分析

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隐匿性乙型肝炎病毒感染的检测及临床特点分析

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