Impact of early virological response to antiviral treatment on the outcomes of hepatitis B-associated liver failure&nbsp;

Peng JianPing; Sun KeWei; Wu YuNan

Issue 10

Oct. 2012

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Article Navigation > Journal of Clinical Hepatology > 2012 > 28(10): 752-755

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Impact of early virological response to antiviral treatment on the outcomes of hepatitis B-associated liver failure

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Published Date: 2012-10-20

Abstract

Abstract

Objective To investigate the impact of early virological response to antiviral treatment on the outcomes of hepatitis B-associated liver failure.Methods One-hundred-and-fifty-two patients with hepatitis B-associated liver failure treated in our hospital from June 2007 to December 2010 were retrospectively enrolled in the study.In addition to standard traditional Chinese medicine therapy (including conventional Hugan soup, JiangMei hepatoprotective treatment, and artificial liver treatment) , all patients were given lamivudine (100 mg/d) or entecavir (0.5 mg/d) .The patients were divided into two groups according to hepatitis B virus (HBV) DNA-negative status (indicating early virological response to treatment) and HBV DNA-positive status at week 4.The levels of total bilirubin (TBil) , prothrombin activity (PTA) , and albumin (Alb) , and the MELD score were determined and compared between the two groups.Treatment outcomes were compared at the end of therapy.The factors that impact on the treatment outcomes were determined by stepwise multivariate logistic regression analysis.Results The patients in the HBV DNA-negative group had significantly lower TBil (P=0.000) but significantly higher PTA (P=0.000) at week 4 of treatment than those in the HBV DNA-positive group.There was no significant difference between the two groups for the Alb level or MELD score.The effective rate of therapy was significantly higher in the HBV DNA-negative group than in the HBV DNA-positive group (74.2% vs 30.5%;χ2=28.15, P=0.0067) .The disease stage and early virological response (occurrence of undetectable HBV DNA at week 4 of treatment) were identified as independent factors impacting treatment outcome.Conclusion The ability for a patient to achieve an early virological response (suppression of viral load) to nucleotide analogue treatment may be an indicator of good prognosis for hepatitis B-associated liver failure.
- hepatitis B virus,
- liver failure

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References

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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Impact of early virological response to antiviral treatment on the outcomes of hepatitis B-associated liver failure

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Impact of early virological response to antiviral treatment on the outcomes of hepatitis B-associated liver failure

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