[1]Reik W, Dean W.DNA methylation and mammalian epigenetics[J].Electrophoresis, 2001, 22:2838-2843.
|
[2]Nishida N, Nagasaka T, Nishimura T, et al.Aberrant methylationof multiple tumor suppressor genes in aging liver, chronic hepatitisand hepatocellular carcinoma[J].Hepatology, 2008, 47 (3) :908-918.
|
[3]Mastuda Y, lchida T, Mastuawa J, et al.p16INK4 is inactive byextensive CpG methlation inhuman hepetocellular carcinoma[J].Gastroenterology, 1999, 116 (2) :394.
|
[4]Kang GH, Lee S, Kim WH, et al.Epstein-Barr virus-positivegastric carcinoma demonstratesfrequent aberrant methylation of mul-tiple genes and constitutes CpG island methylator ph enotype-posi-tive gastric carcinoma[J].Am J Pathol, 2002, 160 (3) :787-794.
|
[5]Kaneto H, Sasaki S, Yamamoto H, et al.Detection of hypermethyl-ation of the p16 (INK4A) gene promoter in chronic hepatitis and cir-rhosis associated with hepatitis B or C virus[J].Gut, 2001, 48 (3) :372-377.
|
[6]Su PF, Lee TC, Lin PJ, et al.Differential DNA methylation associ-ated with hepatitis B virus infection in hepatocellular carcinoma[J].Int J Cancer, 2007, 121 (6) :1257-1264.
|
[7]Shim YH, Yoon GS, Choi HJ, et al.p16 Hypermethylation in theearly stage of hepatitis B virus-associated hepatocarcinogenesis[J].Cancer Lett, 2003, 190 (2) :213-219.
|
[8]Zhang JC, YU ZT, LU J, et al.High Rate of p16 Methylation As-sociated with Hepatitis B Virus Infection in HepatocelluIar Carcino-ma[J].The Chinese German Journal of Clinical Oncology, 2006, 5 (2) :84-89.
|
[9]Wu LM, Zhang F, Zhou L, et al.Predictive value of CpG islandmethylator phenotype for tumor recurrence in hepatitis B virus-as-sociated hepatocellular carcinoma following liver transplantation[J].BMC Cancer, 2010, 10:399.
|
[10]Wei Y, Van Nhieu, Prigent S, et al.Altered expression of E-cad-herin in hepatocellular carcinoma:correlations with geneticalter-ations, beta-catenin expression, and clinical features[J].Hepa-tology, 2002, 36 (3) :692-701.
|
[11]Liu J, Lian Z, Han S, et al.Downregulation of E-cadherin byhepatitis Bvirus X antigen in hepatocellullar carcinoma[J].Onco-gene, 2006, 25 (7) :1008-1017.
|
[12]Xiao WH, Liu WW.Hemizygous deletion and hypermethylation ofRUNX3 gene in hepatocellular carcinoma[J].World J Gastroen-terol, 2004, 10 (3) :376-380.
|
[13]张海元, 云鹏.肝癌细胞系中Run x3基因表达及启动子区异常甲基化分析[J].长江大学学报 (自然科学版) , 2009, 36 (1) :1-3.
|
[14]Kitamura Y, Shirahata A, Sakuraba K, et al.Aberrant Methylationof the Vimentin Gene in Hepatocellular Carcinoma[J].AnticancerRes, 2011, 31 (4) ;1289-1291.
|
[15]Zhu R, Li BZ, Li H, et al.Association of p16INK4A hypermethyl-ation with hepatitis B virus X protein expression in the early stage ofHBV associated hepatocarcinogenesis[J].Pathol Int, 2007, 57 (6) :328-336.
|
[16]Jung JK, Arora P, Pagano JS, et al.Expression of DNA methyl-transferase 1 is activatedby hepatitis B virus X protein via a regulato-ry circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway[J].Cancer Res, 2007, 67 (12) :5771-5778.
|
[17]Lee JO, Kwun HJ, Jung JK, et al.Hepatitis B virus X protein re-presses E-cadherin expression via activation of DNA methyltrans-ferase 1[J].Oncogene, 2005, 24 (44) :6617-6625.
|
[18]Huang J, Wang Y, Guo Y, et al.Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-relatedhepatocellular carcinoma by targeting DNA methyltransferase 1[J].Hepatology, 2010, 52 (1) :60-70.
|
[19]张吉才, 吕军, 李海平, 等.血浆p16启动子异常甲基化在肝癌诊断中的应用价值[J].中华检验医学杂志, 2006, 29 (10) :895-898.
|
[20]Harder J, Opitz OG, Brabender J, et al.Quantitative promotermethylation analysis of hepatocellular carcinoma, cirrhotic and nor-mal liver[J].Int J Cancer, 2008, 122:2800-2804.
|
[21]Wong IH, Zhang J, Lai PB, et al.Quantitative analysis of tumor-derived methylated pl6INK4a sequences in plasma, serum and bloodcells of hepatocellular carcinoma patients[J].Clin Cancer Res, 2003, 9 (3) :1047-1052.
|
[22]Lee HS, Kim BH, Cho NY, et al.Prognostic Implications of andRelationship Between CpG Island Hypermethylation and RepetitiveDNA Hypomethylation in Hepatocellular Carcinoma[J].Clin Canc-er Res, 2009, 15:812-820.
|