胆汁中内毒素的变化对肝损害影响的探讨

To investigate the relationship between the severity of liver injury in patients with bile bacterial infection and the endotoxin in the bile.According to clinical symptoms and signs, 51 patients with bile duct stone were divided into two groups, the selective operation group (n=26) and emergency operation group (n=25) .The levels of endotoxin, endtheline-1 (ET-1) , and calcitonin gene related peptide (CGRP) in the blood were determined during the operation and those of ALT, AST and TBil in the blood were mersured before the operation group.When bile is infected in the patients with bile duct stone, endotoxin can not only directly influcence hepatic injury but also strongly stimulate the hepatobiliary system to synthesize and release ET-1 and CGRP.And imbalance of ET-1 and CGRP possibly plays important role in hepatic injury.