中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

Guidelines on the diagnosis and management of autoimmune hepatitis (2021)

DOI: 10.3760/cma.j.cn112138-20211112-00796
  • Received Date: 2021-12-25
  • Published Date: 2022-01-20
  • Autoimmune hepatitis (AIH) is characterized by elevated serum aminotransferase and immunoglobulin G levels, seropositive results for autoantibodies and moderate to severe interface hepatitis in histologic findings. It will be most helpful in improving survival and life quality, if patients are diagnosed in the early stage and treated appropriately, which also helps relieve social medical burdens. Chinese consensus on the diagnosis and management of autoimmune hepatitis (2015) has contributed to standardizing the diagnosis and treatment of AIH. On the basis of the first consensus, at the end of 2021, under the organization of Chinese Society of Hepatology, experts devise this guide with latest advances aiming to further improve the level of diagnosis and management of autoimmune hepatitis.

     

  • 志谢(以姓氏拼音排序): 安纪红(内蒙古自治区人民医院感染科)、邓国宏(陆军军医大学第一附属医院传染科)、黄燕(中南大学湘雅医院传染科)、黄缘(北京清华长庚医院肝胆内科)、李荣宽(大连医科大学附属二院感染科)、李树臣(哈尔滨医科大学第二附属医院传染科)、陆海英(北京大学第一医院传染科)、石荔(西藏自治区人民医院感染科)、苏明华(广西医科大学第一附属医院感染科)、温志立(南昌大学第二附属医院消化内科)、吴彪(海南省人民医院感染科)、徐京杭(北京大学第一医院肝病科)、杨丽(四川大学华西医院消化内科)、杨积明(天津市第二人民医院感染科)、杨晋辉(昆明医科大学附属二院消化内科)、张缭云(山西医科大学第一医院传染科)、周璐(天津医科大学总医院消化内科)、周永健(广州市第一人民医院消化内科)、祖红梅(青海省第四人民医院传染科)参加本指南制定的讨论, 并提出了富有建设性的意见和建议。
  • [1]
    中华医学会肝病学分会, 中华医学会消化病学分会, 中华医学会感染病学分会. 自身免疫性肝炎诊断和治疗共识(2015)[J]. 临床肝胆病杂志, 2016, 32(1): 9-22. DOI: 10.3969/j.issn.1001-5256.2016.01.002.
    [2]
    de BOER YS, GERUSSI A, van den BRAND FF, et al. Association between black race and presentation and liver-related outcomes of patients with autoimmune hepatitis[J]. Clin Gastroenterol Hepatol, 2019, 17(8): 1616-1624. e2. DOI: 10.1016/j.cgh.2018.11.028.
    [3]
    WANG QX, YAN L, MA X. Autoimmune hepatitis in the Asia-Pacific Area[J]. J Clin Transl Hepatol, 2018, 6(1): 48-56. DOI: 10.14218/JCTH.2017.00032.
    [4]
    LAMBA M, NGU JH, STEDMAN C. Trends in incidence of autoimmune liver diseases and increasing incidence of autoimmune hepatitis[J]. Clin Gastroenterol Hepatol, 2021, 19(3): 573-579. e1. DOI: 10.1016/j.cgh.2020.05.061.
    [5]
    TANAKA A, MORI M, MATSUMOTO K, et al. Increase trend in the prevalence and male-to-female ratio of primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis in Japan[J]. Hepatol Res, 2019, 49(8): 881-889. DOI: 10.1111/hepr.13342.
    [6]
    TANAKA A. Autoimmune Hepatitis: 2019 Update[J]. Gut Liver, 2020, 14(4): 430-438. DOI: 10.5009/gnl19261.
    [7]
    LI Y, YAN L, WANG R, et al. Serum immunoglobulin G levels predict biochemical and histological remission of autoimmune hepatitis type 1: A single-center experience and literature review[J]. Clin Rev Allergy Immunol, 2021. DOI: 10.1007/s12016-021-08833-w.[Online ahead of print]
    [8]
    WANG QX, JIANG WJ, MIAO Q, et al. Clinical and histological features of autoantibody-negative autoimmune hepatitis in Chinese patients: A single center experience[J]. J Dig Dis, 2013, 14(4): 175-180. DOI: 10.1111/1751-2980.12022.
    [9]
    DHALIWAL HK, HOEROLDT BS, DUBE AK, et al. Long-term prognostic significance of persisting histological activity despite biochemical remission in autoimmune hepatitis[J]. Am J Gastroenterol, 2015, 110(7): 993-999. DOI: 10.1038/ajg.2015.139.
    [10]
    GURUNG A, ASSIS DN, MCCARTY TR, et al. Histologic features of autoimmune hepatitis: A critical appraisal[J]. Hum Pathol, 2018, 82: 51-60. DOI: 10.1016/j.humpath.2018.07.014.
    [11]
    MIAO Q, BIAN Z, TANG R, et al. Emperipolesis mediated by CD8 T cells is a characteristic histopathologic feature of autoimmune hepatitis[J]. Clin Rev Allergy Immunol, 2015, 48(2-3): 226-235. DOI: 10.1007/s12016-014-8432-0.
    [12]
    STRAVITZ RT, LEFKOWITCH JH, FONTANA RJ, et al. Autoimmune acute liver failure: Proposed clinical and histological criteria[J]. Hepatology, 2011, 53(2): 517-526. DOI: 10.1002/hep.24080
    [13]
    TAKAHASHI A, ARINAGA-HINO T, OHIRA H, et al. Autoimmune hepatitis in Japan: Trends in a nationwide survey[J]. J Gastroenterol, 2017, 52(5): 631-640. DOI: 10.1007/s00535-016-1267-0.
    [14]
    ALVAREZ F, BERG PA, BIANCHI FB, et al. International Autoimmune Hepatitis Group Report: Review of criteria for diagnosis of autoimmune hepatitis[J]. J Hepatol, 1999, 31(5): 929-938. DOI: 10.1016/s0168-8278(99)80297-9.
    [15]
    HENNES EM, ZENIYA M, CZAJA AJ, et al. Simplified criteria for the diagnosis of autoimmune hepatitis[J]. Hepatology, 2008, 48(1): 169-176. DOI: 10.1002/hep.22322.
    [16]
    QIU D, WANG Q, WANG H, et al. Validation of the simplified criteria for diagnosis of autoimmune hepatitis in Chinese patients[J]. J Hepatol, 2011, 54(2): 340-347. DOI: 10.1016/j.jhep.2010.06.032.
    [17]
    GALASKI J, WEILER-NORMANN C, SCHAKAT M, et al. Update of the simplified criteria for autoimmune hepatitis: Evaluation of the methodology for immunoserological testing[J]. J Hepatol, 2021, 74(2): 312-320. DOI: 10.1016/j.jhep.2020.07.032.
    [18]
    CHEN RL, WANG QX, MA X. Precision medicine for autoimmune hepatitis[J]. J Dig Dis, 2019, 20(7): 331-337. DOI: 10.1111/1751-2980.12786.
    [19]
    WANG Z, SHENG L, YANG Y, et al. The management of autoimmune hepatitis patients with decompensated cirrhosis: Real-world experience and a comprehensive review[J]. Clin Rev Allergy Immunol, 2017, 52(3): 424-435. DOI: 10.1007/s12016-016-8583-2.
    [20]
    PEISELER M, LIEBSCHER T, SEBODE M, et al. Efficacy and limitations of budesonide as a second-line treatment for patients with autoimmune hepatitis[J]. Clin Gastroenterol Hepatol, 2018, 16(2): 260-267. e1. DOI: 10.1016/j.cgh.2016.12.040.
    [21]
    MANNS MP, WOYNAROWSKI M, KREISEL W, et al. Budesonide induces remission more effectively than prednisone in a controlled trial of patients with autoimmune hepatitis[J]. Gastroenterology, 2010, 139(4): 1198-1206. DOI: 10.1053/j.gastro.2010.06.046.
    [22]
    WOYNAROWSKI M, NEMETH A, BARUCH Y, et al. Budesonide versus prednisone with azathioprine for the treatment of autoimmune hepatitis in children and adolescents[J]. J Pediatr, 2013, 163(5): 1347-1353. e1. DOI: 10.1016/j.jpeds.2013.05.042.
    [23]
    EFE C, HAGSTRÖM H, YTTING H, et al. Efficacy and safety of mycophenolate mofetil and tacrolimus as second-line therapy for patients with autoimmune hepatitis[J]. Clin Gastroenterol Hepatol, 2017, 15(12): 1950-1956. e1. DOI: 10.1016/j.cgh.2017.06.001.
    [24]
    LIBERAL R, de BOER YS, ANDRADE RJ, et al. Expert clinical management of autoimmune hepatitis in the real world[J]. Aliment Pharmacol Ther, 2017, 45(5): 723-732. DOI: 10.1111/apt.13907.
    [25]
    DE LEMOS-BONOTTO M, VALLE-TOVO C, COSTABEBER AM, et al. A systematic review and meta-analysis of second-line immunosuppressants for autoimmune hepatitis treatment[J]. Eur J Gastroenterol Hepatol, 2018, 30(2): 212-216. DOI: 10.1097/MEG.0000000000001019.
    [26]
    HANOUNEH M, RITCHIE MM, ASCHA M, et al. A review of the utility of tacrolimus in the management of adults with autoimmune hepatitis[J]. Scand J Gastroenterol, 2019, 54(1): 76-80. DOI: 10.1080/00365521.2018.1551498.
    [27]
    MONTANO-LOZA AJ, BHANJI RA, WASILENKO S, et al. Systematic review: Recurrent autoimmune liver diseases after liver transplantation[J]. Aliment Pharmacol Ther, 2017, 45(4): 485-500. DOI: 10.1111/apt.13894.
    [28]
    MACK CL, ADAMS D, ASSIS DN, et al. Diagnosis and management of autoimmune hepatitis in adults and children: 2019 practice guidance and guidelines from the American Association for the Study of Liver Diseases[J]. Hepatology, 2020, 72(2): 671-722. DOI: 10.1002/hep.31065.
    [29]
    KERKAR N, YANNI G. 'De novo' and 'recurrent' autoimmune hepatitis after liver transplantation: A comprehensive review[J]. J Autoimmun, 2016, 66: 17-24. DOI: 10.1016/j.jaut.2015.08.017.
    [30]
    MORIYAMA T, NISHⅡ R, PEREZ-ANDREU V, et al. NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity[J]. Nat Genet, 2016, 48(4): 367-373. DOI: 10.1038/ng.3508.
    [31]
    LOHSE AW, SEBODE M, J∅RGENSEN MH, et al. Second-line and third-line therapy for autoimmune hepatitis: A position statement from the European Reference Network on Hepatological Diseases and the International Autoimmune Hepatitis Group[J]. J Hepatol, 2020, 73(6): 1496-1506. DOI: 10.1016/j.jhep.2020.07.023.
    [32]
    XU Q, SHENG L, BAO H, et al. Evaluation of transient elastography in assessing liver fibrosis in patients with autoimmune hepatitis[J]. J Gastroenterol Hepatol, 2017, 32(3): 639-644. DOI: 10.1111/jgh.13508.
    [33]
    HARTL J, EHLKEN H, SEBODE M, et al. Usefulness of biochemical remission and transient elastography in monitoring disease course in autoimmune hepatitis[J]. J Hepatol, 2018, 68(4): 754-763. DOI: 10.1016/j.jhep.2017.11.020.
    [34]
    FIX OK, BLUMBERG EA, CHANG KM, et al. American Association for the Study of Liver Diseases Expert Panel consensus statement: Vaccines to prevent coronavirus disease 2019 infection in patients with liver disease[J]. Hepatology, 2021, 74(2): 1049-1064. DOI: 10.1002/hep.31751.
    [35]
    CORNBERG M, BUTI M, EBERHARDT CS, et al. EASL position paper on the use of COVID-19 vaccines in patients with chronic liver diseases, hepatobiliary cancer and liver transplant recipients[J]. J Hepatol, 2021, 74(4): 944-951. DOI: 10.1016/j.jhep.2021.01.032.
    [36]
    BIEWENGA M, INDERSON A, TUSHUIZEN ME, et al. Early predictors of short-term prognosis in acute and acute severe autoimmune hepatitis[J]. Liver Transpl, 2020, 26(12): 1573-1581. DOI: 10.1002/lt.25906.
    [37]
    ZACHOU K, ARVANITI P, AZARIADIS K, et al. Prompt initiation of high-dose i. v. corticosteroids seems to prevent progression to liver failure in patients with original acute severe autoimmune hepatitis[J]. Hepatol Res, 2019, 49(1): 96-104. DOI: 10.1111/hepr.13252.
    [38]
    YEOMAN AD, WESTBROOK RH, ZEN Y, et al. Prognosis of acute severe autoimmune hepatitis (AS-AIH): The role of corticosteroids in modifying outcome[J]. J Hepatol, 2014, 61(4): 876-882. DOI: 10.1016/j.jhep.2014.05.021.
    [39]
    REDDY HG, SCHNEIDER BJ, TAI AW. Immune checkpoint inhibitor-associated colitis and hepatitis[J]. Clin Transl Gastroenterol, 2018, 9(9): 180. DOI: 10.1038/s41424-018-0049-9.
    [40]
    CZAJA AJ. Immune inhibitory proteins and their pathogenic and therapeutic implications in autoimmunity and autoimmune hepatitis[J]. Autoimmunity, 2019, 52(4): 144-160. DOI: 10.1080/08916934.2019.1641200.
    [41]
    LOOMBA R, LIANG TJ. Hepatitis B reactivation associated with immune suppressive and biological modifier therapies: Current concepts, management strategies, and future directions[J]. Gastroenterology, 2017, 152(6): 1297-1309. DOI: 10.1053/j.gastro.2017.02.009.
    [42]
    LIN XQ, SHENG L, XIAO X, et al. Analysis of clinical diagnosis and treatment in chronic hepatitis B combined with autoimmune hepatitis[J]. Chin J Hepatol, 2020, 28(4): 351-356. DOI: 10.3760/cma.j.cn501113-20190120-00020.

    林小钦, 盛黎, 肖潇, 等. 慢性乙型肝炎合并自身免疫性肝炎的临床诊治分析[J]. 中华肝脏病杂志, 2020, 28(4): 351-356. DOI: 10.3760/cma.j.cn501113-20190120-00020.
    [43]
    MIELI-VERGANI G, VERGANI D, BAUMANN U, et al. Diagnosis and management of pediatric autoimmune liver disease: ESPGHAN hepatology committee position statement[J]. J Pediatr Gastroenterol Nutr, 2018, 66(2): 345-360. DOI: 10.1097/MPG.0000000000001801.
    [44]
    NASTASIO S, SCIVERES M, MATARAZZO L, et al. Long-term follow-up of children and young adults with autoimmune hepatitis treated with cyclosporine[J]. Dig Liver Dis, 2019, 51(5): 712-718. DOI: 10.1016/j.dld.2018.10.018.
    [45]
    EFE C, TAⅡ HA, YTTING H, et al. Tacrolimus and mycophenolate mofetil as second-line therapies for pediatric patients with autoimmune hepatitis[J]. Dig Dis Sci, 2018, 63(5): 1348-1354. DOI: 10.1007/s10620-018-5011-x.
    [46]
    WANG Q, QIU D, MA X. Early normalisation of aminotransferase predicts complete biochemical remission in autoimmune hepatitis patients[J]. Aliment Pharmacol Ther, 2011, 34(1): 107-109. DOI: 10.1111/j.1365-2036.2011.04690.x.
    [47]
    TANSEL A, KATZ LH, EL-SERAG HB, et al. Incidence and determinants of hepatocellular carcinoma in autoimmune hepatitis: A systematic review and Meta-analysis[J]. Clin Gastroenterol Hepatol, 2017, 15(8): 1207-1217. e4. DOI: 10.1016/j.cgh.2017.02.006.
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    18. 陈杰,周长雄,龚秀敏,郭治. Ⅰ型自身免疫性肝炎患者IL28RA、PD-L1表达及与肝功能的相关性分析. 中国现代医学杂志. 2024(12): 78-83 .
    19. 李慧,张佳庆,赵娜,彭雪莹,赵占娟,王阳阳. Th17和Treg细胞在自身免疫性肝炎发生发展中的作用研究进展. 胃肠病学和肝病学杂志. 2024(05): 618-622 .
    20. 德吉央宗,旺加. 自身免疫性肝病合并干燥综合征一例报道. 西藏医药. 2024(03): 159-160 .
    21. 陈欣欣,张海萍,黄春洋,闫惠平. 有乙型肝炎病毒感染史的自身免疫性肝炎患者的病毒学特征分析. 传染病信息. 2024(01): 5-10 .
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    25. 钟淑勤,莫海兴,邓锦满. 自身免疫性肝炎患者血清miR431-5-p和miR143-3-p表达与病情严重程度的关系研究. 国际检验医学杂志. 2024(13): 1656-1660 .
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    31. 中华医学会器官移植学分会,中国医药生物技术协会移植技术分会. 中国肾脏移植受者生育管理指南(2023版). 中华器官移植杂志. 2024(07): 432-450 .
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    35. 于敏,仲跻凤,季瑜. 实时剪切波弹性成像联合血清IL-6/IL-22水平与自身免疫性肝病肝纤维化的相关性. 肝脏. 2024(08): 919-923 .
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    37. 李艳,冯伟广,郭付全,刘慧敏,孙秀娟. HIV感染合并自身免疫性肝炎-原发性胆汁性胆管炎重叠综合征1例. 中国艾滋病性病. 2024(10): 1082-1084 .
    38. 谢翀,肖影群. 阿托伐他汀诱导的自身免疫样肝炎1例及文献复习. 南昌大学学报(医学版). 2024(05): 103-107 .
    39. 王莉芬,朱金霞,刘光伟. 肠道微生物、Th17细胞和Treg细胞影响自身免疫性肝炎的研究进展. 中西医结合肝病杂志. 2024(10): 948-952 .
    40. 梁燕楼,王子弦,陈杉杉,吴静. 二维剪切波弹性成像在不同类型自身免疫性肝病纤维化分期中的应用. 南通大学学报(医学版). 2024(05): 464-468 .
    41. 中国医疗保健国际交流促进会基层检验技术标准化分会. 基层医疗机构开展自身抗体检测与应用的专家共识. 中华预防医学杂志. 2024(12): 1835-1852 .
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    43. 陈克岩,吴婷,杨灿. T淋巴细胞线粒体损伤指数在自身免疫性肝炎患者中的临床意义及影响因素. 肝脏. 2024(11): 1409-1412+1426 .
    44. 李晔,李晓松,李梅,李旭艳,王楷,刘兵兵,孟宇. 3种方法学检测抗核抗体谱结果分析. 标记免疫分析与临床. 2024(11): 2036-2040 .
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    46. 王雪鑫,李颖霞,姜利彬,周明霞,魏大鹏,张晓朋,温洪涛. 实时剪切波弹性成像对自身免疫性肝炎纤维化的诊断价值. 临床肝胆病杂志. 2023(01): 97-103 . 本站查看
    47. 胡蓝烁,黄炫淳,杨先照. 基于“厥阴不治,求之阳明”从调木、理土、畅腑论治自身免疫性肝炎. 环球中医药. 2023(01): 111-115 .
    48. 王丽,杨永峰. 自身免疫性肝炎诊治——病理必不可缺. 临床肝胆病杂志. 2023(03): 504-510 . 本站查看
    49. 郝君玉,刘光伟,谢露,范文艳,陈虹秀. 中药有效成分干预自身免疫性肝炎相关信号通路的研究进展. 临床肝胆病杂志. 2023(03): 663-670 . 本站查看
    50. 肿瘤合并肝损伤患者血小板减少症管理中国专家共识(2022版). 肿瘤防治研究. 2023(03): 211-223 .
    51. 杨秀英,党小红,姜洋. 自身免疫性肝炎的药物治疗进展. 临床肝胆病杂志. 2023(04): 915-921 . 本站查看
    52. 张丽丽,胡建华,王一同,包一珺,吕文良. 基于《理虚元鉴》理论浅探自身免疫性肝炎的防治. 环球中医药. 2023(04): 740-742 .
    53. 甄永利,张亚飞,张振华. 自身免疫性肝病患者甲状腺功能变化及其对治疗应答的影响. 实用肝脏病杂志. 2023(04): 508-511 .
    54. 杨航,赵黎莉,韩萍,陈庆灵,文君,刘洁,程晓静,李嘉. 血清壳多糖酶3样蛋白1(CHI3L1)对肝硬化患者发生失代偿事件风险的预测价值. 临床肝胆病杂志. 2023(07): 1578-1585 . 本站查看
    55. 赵娟,徐斌. 进修医师自身免疫性肝炎临床带教体会. 继续医学教育. 2023(06): 129-132 .
    56. 姚尚娟,李依琳,陈明洁,李强. 自身免疫性肝病重叠综合征的诊断和治疗. 临床肝胆病杂志. 2023(08): 1952-1957 . 本站查看
    57. 王翠,王芬,陈林. 遂宁市中心医院2006~2022年常见非感染性肝病分布特征及变化趋势分析. 现代消化及介入诊疗. 2023(05): 573-577 .
    58. 彭世秀,李春燕,黄爱萍,朱松涛,麦静,伍丽萍. HIV感染合并自身免疫性肝炎-原发性胆汁性胆管炎重叠综合征1例报告. 临床肝胆病杂志. 2023(09): 2175-2178 . 本站查看
    59. 徐志远,杨永峰. 2012-2021年南京市第二医院肝病住院患者疾病谱及变化趋势分析. 临床肝胆病杂志. 2023(09): 2137-2144 . 本站查看
    60. 于航,闫涛,孙耀. 肝病相关血小板减少症临床管理中国专家共识. 临床肝胆病杂志. 2023(10): 2307-2320 . 本站查看
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