HLA-A基因频率与HBV感染的相关性研究

To study the frequency of different genotypings of HLA-A gene and their relations with HBV infection.HLA-A genotyping was conducted in 30 cases of HBV chronic infection, 30 cases of chronic carriers with HBV, 30 cases of patients that recovered from acute HBV infection.and 50 healthy subjects with polymerase chain reaction-sequence specific primer (PCR-SSP) .The relationship of different genotypes of HLA-A with the clinical types of HBV infection was analyzed.HLA-A0201 was the frequent genotype in the healthy residents of JiNan with the frequency of 52%.The frequency of HLA-A0201 was decreased in patients with chronic hepatitis B.The frequency of HLA-A0301 was increased in patients with chronic hepatitis B (P<0.05) .HLA-A1101 was usually found in chronic carriers with HBV.HLA-A0201 was increased in patients that recoverd from acute HBV infection.HLA-A0201、A0301 are related to hepatitis B in JiNan, HLA-A1101 is related to carriers with HBV.And immune and genetic factors participate in the pathogenesis of hepatitis B.