To investigate the relationship between HLA-A alleles polymorphism and susceptibility to HBV in the Han nationality in Xuzhou.Typing HLA-A genotype was performed by using PCR-SSP (polymerase chain reaction-sequence specific primers technique) in seventy-nine patients with hepatitis B and ninty-six healthy people in Xuzhou of China.The frequency of HLA-A*0201-0217 allele was 45.57% in patient group, which was higher than that (29.69%) of the normal healthy people (x2=9.394, P<0.05, RR=1.983, 95%CI:1.2273.080) .The susceptibility to chronic hepatitis B might be strongly associated with HLA-A*0201-0217 allele of Chinese patients in Xuzhou.
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