To detect HBV DNA and its genotypes. HBV DNA and its genotype was detected by Polymerase Chain Reaction and Nucleic Acid hybridization. Of 50 HBV DNA positive patients who lived in Guangdong, 34 samples (68%) are type C, 5 samples (10%) type B, 3 samples (6%) type D, 1 sample (2%) type F, 4 samples (8%) mixed type (3 BC, 1 BCD) , meanwhile 3 samples (6%) couldn't be typed by this method. In the detected samples, the major genotype of HBV DNA is type C, several are type B, D or F. The type A and E haven't been found. The result suggests there may be some other genotypes in Guangdong area.
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