Correlation of the serum levels of adiponectin， omentin， and visfatin with the severity of acute pancreatitis

Xin XU; Zhangxing CHEN

doi:10.12449/JCH240920

Volume 40 Issue 9

Sep. 2024

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Correlation of the serum levels of adiponectin， omentin， and visfatin with the severity of acute pancreatitis

DOI: 10.12449/JCH240920

Xin XU^{,
,},
Zhangxing CHEN

Department of Gastroenterology，Chenggong Hospital Affiliated to Xiamen University，Xiamen，Fujian 361000，China

Research funding:

Xiamen City Health Guidance Project (3502Z20199063)

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Corresponding author: XU Xin， xuxing19891031@126.com （ORCID： 0000-0002-2966-9459）
Received Date: 2024-01-19
Accepted Date: 2024-04-07
Published Date: 2024-09-25

Abstract

Abstract

Objective To investigate the correlation of the serum levels of adiponectin， omentin， and visfatin with the severity of acute pancreatitis （AP）. Methods Blood samples were collected from 35 healthy individuals in the control group and 70 patients with AP who were admitted to Chenggong Hospital Affiliated to Xiamen University from March 2022 to October 2023， and enzyme-linked immunosorbent assay was used to measure the serum levels of adiponectin， omentin， and visfatin in each group within 24 hours after admission. The analysis of variance was used for comparison of continuous between groups， and the LSD-t test was used for further comparison between two groups； the chi-square test was used for comparison of categorical data between groups. The Pearson correlation analysis was used to investigate the correlation between indicators， and the receiver operating characteristic （ROC） curve was used to investigate the value of the three indicators in predicting severe acute pancreatitis （SAP）. Results Compared with the control group， the AP group had significantly higher serum levels of omentin and visfatin （t=5.51 and 9.41， both P<0.01）， and the level of visfatin gradually increased with the aggravation of the disease （F=43.32， P<0.01）， while there was no significant change in omentin with the aggravation of the disease （F=0.47， P>0.05）. The AP group had a significantly lower level of adiponectin than the control group （t=-14.47， P <0.01）， and the level of adiponectin gradually decreased with the aggravation of the disease （F=35.61， P<0.01）. The serum level of visfatin was positively correlated with Acute Physiology and Chronic Health Evaluation II （APACHE-II） score （r=0.547， P<0.01）， and the level of adiponectin was negatively correlated with APACHE-II score （r=-0.520， P<0.01）， while there was no significant correlation between omentin APACHE-II score （r=0.007， P>0.05）. The three indicators had an area under the ROC curve （AUC） of 0.893， 0.570， and 0.829， respectively， in predicting SAP， and combined measurement of adiponectin and visfatin with an AUC of >0.7 showed an AUC of 0.953 in predicting SAP， with a sensitivity of 0.900 and a specificity of 0.933. Conclusion The serum levels of adiponectin and visfatin are correlated with the severity of AP and have an important clinical significance in predicting SAP， and combined measurement of the two indicators has a higher value， while further studies are needed to investigate the correlation of omentin level with the severity of AP.
- Pancreatitis， Acute Necrotizing,
- Adiponectin,
- Nicotinamide Phosphoribosyltransferase

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Correlation of the serum levels of adiponectin， omentin， and visfatin with the severity of acute pancreatitis

DOI: 10.12449/JCH240920

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Correlation of the serum levels of adiponectin， omentin， and visfatin with the severity of acute pancreatitis

DOI: 10.12449/JCH240920

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