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Volume 40 Issue 2
Feb.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(2): 413-418

Role of mitophagy in the development and progression of liver-related diseases

DOI: 10.12449/JCH240232

  • Basic Medical Academy，Shaanxi University of Chinese Medicine，Xianyang，Shaanxi 712046，China

Research funding:

National Natural Science Foundation of China Youth Science Foundation Project (81704073);

General Projects of Key R & D Program of Science and Technology Department of Shaanxi Province (2022SF-225)

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  • Corresponding author: SHI Xiaoyan， biosalome@163.com （ORCID： 0009-0007-8350-0826）
  • Received Date: 2023-05-14
  • Accepted Date: 2023-06-16
  • Published Date: 2024-02-19
    Abstract
  • Mitophagy is a type of selective autophagy during which cells specifically remove damaged mitochondria in response to nutrient deficiency or external stimulation and thus maintain the integrity of mitochondrial function and cellular homeostasis. In recent years， a large number of studies have shown that dysfunction of mitophagy is closely associated with the development and progression of various liver-related diseases such as nonalcoholic fatty liver disease， drug-related liver injury， viral hepatitis， and hepatocellular carcinoma. This article summarizes the specific mechanisms of mitophagy in regulating liver-related diseases and further elaborates on the potential therapeutic targets of mitophagy in liver-related diseases， in order to provide more effective therapeutic strategies for the clinical treatment of liver diseases.

     

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