Molecular mechanisms of the interaction between hepatitis B virus infection and mitochondrial homeostasis

Xingtong LI; Taicheng ZHOU

doi:10.12449/JCH250222

Volume 41 Issue 2

Feb. 2025

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Article Navigation > Journal of Clinical Hepatology > 2025 > 41(2): 343-348

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Molecular mechanisms of the interaction between hepatitis B virus infection and mitochondrial homeostasis

DOI: 10.12449/JCH250222

Xingtong LI,
Taicheng ZHOU^{,
,}

Department of Central Laboratory，Affiliated Hospital of Yunnan University，Kunming 650021，China

Research funding:

Yunnan Provincial Department of Science and Technology-Kunming Medical University Basic Research Joint Special Project (202101AY070001-283);

Yunnan Province High-level Scientific and Technological Talents and Innovative Teams Selection Special Programme (202105AC160048)

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Corresponding author: ZHOU Taicheng， zhoutc@ynshhyy.com （ORCID： 0000-0001-8457-1959）
Received Date: 2024-07-02
Accepted Date: 2024-08-23
Published Date: 2025-02-25

Abstract

Abstract

Hepatitis B virus （HBV） infection can cause acute or chronic infection， while untreated patients can develop into liver cirrhosis or liver cancer， thereby leading to death. As one of the most important organelles of cells， the maintenance of the normal morphology and function of mitochondria is the basis for ensuring various physiological activities in cells， and physiological activities， such as mitochondrial dynamics， mitophagy， injury， and oxidative phosphorylation， can affect the maintenance of mitochondrial homeostasis. HBV infection can affect mitochondrial homeostasis. This article summarizes the research advances in mitochondrial homeostasis and HBV infection from the four aspects of mitochondrial dynamics， mitophagy， mitochondrial oxidative phosphorylation， and mitochondrial injury and discusses the association between the maintenance of mitochondrial homeostasis and HBV infection， in order to provide a theoretical basis for understanding the molecular mechanism of HBV infection and identifying the potential therapeutic targets for HBV.
- Hepatitis B Virus,
- Mitochondria,
- Mitochondrial Dynamics,
- Mitophagy,
- Oxidative Phosphorylation

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致谢: 感谢王华庆、王潇滟、乔建荣、任明辉、庄辉、李增德、周脉耕、郑徽、徐小元、梁晓峰等专家对本文撰写提供的支持和帮助。

References(55)

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Molecular mechanisms of the interaction between hepatitis B virus infection and mitochondrial homeostasis

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Molecular mechanisms of the interaction between hepatitis B virus infection and mitochondrial homeostasis

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