Role of autophagy in treatment of paracetamol-induced liver injury

Guojing XING; Lifei WANG; Longlong LUO; Xiaofeng ZHENG; Chun GAO; Xiaohui YU; Jiucong ZHANG

doi:10.12449/JCH250229

Volume 41 Issue 2

Feb. 2025

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Article Navigation > Journal of Clinical Hepatology > 2025 > 41(2): 389-394

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Role of autophagy in treatment of paracetamol-induced liver injury

DOI: 10.12449/JCH250229

Guojing XING^{1a, 1b, 2},
Lifei WANG^1a,
Longlong LUO^1a,
Xiaofeng ZHENG³,
Chun GAO^1a,
Xiaohui YU^1a,
Jiucong ZHANG^{1a
,
,
,}

1a.
Department of Gastroenterology，Lanzhou 730050，China
1b.
Gansu Provincial Key Laboratory of Stem Cells and Genetic Drugs，The 940 Hospital of Joint Logistic Support Force of PLA，Lanzhou 730050，China
2.
Department of Gastroenterology，General Hospital of Ningxia Medical University，Yinchuan 750001，China
3.
Department of Gastroenterology，The Second Hospital of Lanzhou University，Lanzhou 730030，China

Research funding:

Gansu Province Health Care Industry Research Program (GSWSKY2023-34);

Special Projects for Graduate Student Supervisors of the 940th Hospital (2023YXKY020);

Project of Excellent Youth Team Training for the Central Universities (31920220065);

Gansu Provincial Clinical Medical Research Center for Non-infectious Liver Diseases (21JR7RA017)

More Information

Corresponding author: ZHANG Jiucong， zhangjiucong@163.com （ORCID： 0000-0003-4006-3033）
Received Date: 2024-06-23
Accepted Date: 2024-07-04
Published Date: 2025-02-25

Abstract

Abstract

N-acetyl-p-aminophenol （APAP） is an antipyretic analgesic commonly used in clinical practice， and APAP overdose can cause severe liver injury and even death. In recent years， the incidence rate of APAP-induced liver injury （AILI） tends to increase， and it has become the second most common cause of liver transplantation worldwide. Autophagy is a highly conserved catabolic process that removes unwanted cytosolic proteins and organelles through lysosomal degradation to achieve the metabolic needs of cells themselves and the renewal of organelles. A large number of studies have shown that autophagy plays a key role in the pathophysiology of AILI， involving the mechanisms such as APAP protein conjugates， oxidative stress， JNK activation， mitochondrial dysfunction， inflammatory response and apoptosis. This article elaborates on the biological mechanism of autophagy in AILI， in order to provide a theoretical basis for the treatment of AILI and the development of autophagy regulators.
- Autophagy,
- Acetaminophen,
- Chemical and Drug Indued Liver Injury,
- Pathologic Processes

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References

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Role of autophagy in treatment of paracetamol-induced liver injury

DOI: 10.12449/JCH250229

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Role of autophagy in treatment of paracetamol-induced liver injury

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