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Volume 40 Issue 9
Sep.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(9): 1916-1923

Research advances in the degradation of hepatic lipid droplets through the autophagy pathway

DOI: 10.12449/JCH240931

  • Center for Safety Evaluation of drugs，Heilongjiang University of Chinese Medicine，Harbin 150040，China

Research funding:

General Project of National Natural Science Foundation of China (81573135);

Natural Science Foundation of Heilongjiang Province of China (LH2023H056);

Heilongjiang Postdoctoral Research Initiation Program (LBH-Q21042)

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  • Corresponding author: LI Baolong， lbl73@163.com （ORCID： 0009-0008-1930-2224）
  • Received Date: 2023-12-21
  • Accepted Date: 2024-02-21
  • Published Date: 2024-09-25
    Abstract
  • Autophagy is a highly conserved cellular degradation pathway that degrades lipid droplets through a process called “lipophagy”. Lipophagy can selectively recognize lipid substances and degrade them， promoting β oxidation and thereby maintaining the balance of intracellular lipid metabolism. The liver regulates lipid droplet metabolism through lipophagy signaling pathways or key molecules， thereby alleviating hepatic steatosis and improving nonalcoholic fatty liver disease （NAFLD）. This article reviews the latest advances in the degradation of hepatic lipid droplets through the three autophagic pathways of macroautophagy， molecular chaperone-mediated autophagy， and microautophagy. The major signaling pathways of AMPK/mTOR-ULK1， ATGL-SIRT1， FGF21-JMJD3， and Akt are involved in the regulation of the lipophagy process and help to maintain the homeostasis of lipid metabolism in the liver， so as to provide new ideas for clinical prevention and treatment of NAFLD.

     

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