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Vol.40 No.10 (288 in total) Oct. 2024
Theme Issue: Advances in Traditional Chinese Medicine Treatment of Fatty Liver
Executive Chief Editor: LI Xiuhui  
Beijing YouAn Hospital，Capital Medical University
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Editorial
Research advances in traditional Chinese medicine syndromes of fatty liver disease
Junting SAI, Xiuhui LI
2024, 40(10): 1929-1932. DOI: 10.12449/JCH241001
Abstract(1876) HTML (181) PDF (595KB)(114) Cited By (1)
Abstract:
Fatty liver disease can be classified into alcoholic fatty liver disease and nonalcoholic fatty liver disease based on etiology， and it has become the most important liver disease worldwide. Due to the differences in the etiology and pathological mechanism of fatty liver disease， it may manifest as ...
Expert Forum
Active components of traditional Chinese medicine and their compound prescriptions in prevention and treatment of nonalcoholic fatty liver disease： Current status and prospects
Yuqing PAN, Aojie MAO, Chuchu YU, Yiyang HU
2024, 40(10): 1933-1941. DOI: 10.12449/JCH241002
Abstract(1336) HTML (262) PDF (838KB)(150) Cited By (2)
Abstract:
Nonalcoholic fatty liver disease （NAFLD） is currently a chronic liver disease with the highest prevalence rate in the world， with complex pathogeneses and limited clinical treatment methods. Over the past 20 years， the discovery of active components for NAFLD treatment from traditional Chinese medic...
Effect and mechanism of external therapy of traditional Chinese medicine in treatment of nonalcoholic fatty liver disease
Wenxia ZHAO, Peiwei YANG
2024, 40(10): 1942-1948. DOI: 10.12449/JCH241003
Abstract(1640) HTML (164) PDF (860KB)(75) Cited By (1)
Abstract:
Nonalcoholic fatty liver disease （NAFLD） is a common metabolic disease， and in recent years， the incidence rate of NAFLD is gradually increasing， which seriously threatens human health. As a traditional treatment method， external therapy of traditional Chinese medicine （TCM） has shown unique advanta...
Theoretical and clinical practice of metabolic associated fatty liver disease based on the theory of “six stagnation diseases”
Guangdong TONG, Yuxin SUN
2024, 40(10): 1949-1953. DOI: 10.12449/JCH241004
Abstract(1314) HTML (126) PDF (664KB)(64)
Abstract:
Metabolic associated fatty liver disease （MAFLD） has become the most common liver disease in the world， including simple hepatic steatosis， steatohepatitis， liver fibrosis/cirrhosis， and liver cancer， and it is often associated with metabolic syndrome. MAFLD has complex pathological manifestations， ...
Research advances in the pathogenesis of metabolic associated fatty liver disease
Shukun YAO, Jing LIU, Tianhui ZHOU
2024, 40(10): 1954-1958. DOI: 10.12449/JCH241005
Abstract(1109) HTML (208) PDF (679KB)(86)
Abstract:
Metabolic associated fatty liver disease （MAFLD） is currently the most common liver disease around the world. MAFLD may easily progress to the adverse outcomes such as hepatitis， liver fibrosis， and liver cirrhosis， and it is often accompanied by comorbidities such as diabetes， hypertension， hyperli...
Guideline
Expert consensus on Traditional Chinese Medicine diagnosis and treatment of jaundice（2023）
Branch of Gastrointestinal Diseases， China Association of Chinese Medicine
2024, 40(10): 1959-1966. DOI: 10.12449/JCH241006
Abstract(985) HTML (380) PDF (1067KB)(159) Cited By (2)
Abstract:
Jaundice is one of the common clinical symptoms，which is characterized by eyes stained yellow especially. The classification and prescription of jaundice are improved continuously. This consensus describes the history of jaundice，etiology and pathogenesis，common symptoms，clinical treatment，evaluatio...
Chinese expert consensus on single-incision laparoscopic cholecystectomy （2024 edition）
Minimally Invasive Surgery Committee of the Chinese Research Hospital Association
2024, 40(10): 1967-1972. DOI: 10.12449/JCH241007
Abstract(911) HTML (212) PDF (908KB)(258)
Abstract:
An excerpt of American College of Gastroenterology guidelines： Management of acute pancreatitis （2024）
Yingxiao SONG, Huiyun ZHU, Yiqi. DU
2024, 40(10): 1973-1975. DOI: 10.12449/JCH241008
Abstract(1572) HTML (357) PDF (478KB)(571) Cited By (1)
Abstract:
The American College Gastroenterology （ACG） recently released the 2024 edition of Guidelines for the management of acute pancreatitis. The guidelines first discuss the diagnosis， etiology， severity， and early management of acute pancreatitis， as well as the management of complications， especially pa...
Viral Hepatitis
Risk factors for the prognosis of elderly patients with hepatitis B virus-related acute-on-chronic liver failure and construction of a nomogram model for risk prediction
Shihua ZHANG, Chengzhi BAI, Chunyan LI, Limao XU, Huaqian XU, Shanhong TANG
2024, 40(10): 1976-1984. DOI: 10.12449/JCH241009
Abstract(531) HTML (110) PDF (1398KB)(68)
Abstract:
Objective To investigate the clinical features of elderly patients with hepatitis B virus-related acute-on-chronic liver failure （HBV-ACLF） and the risk factors affecting the short-term prognosis of patients. Methods A retrospective analysis was performed for 417 patients with HBV-ACLF who were admi...
Influence of metabolism-related factors on the short-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure and establishment of a predictive model
Wenling LUO, Yu ZENG, Xuemei ZHANG, Yunjian SHENG
2024, 40(10): 1985-1991. DOI: 10.12449/JCH241010
Abstract(312) HTML (117) PDF (903KB)(39)
Abstract:
Objective To investigate the influence of metabolism-related factors （overweight and/or obesity， hyperglycemia， hypertension and dyslipidemia）on the 90-day prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure （HBV-ACLF）， and to establish a predictive model. Methods A r...
Fatty Liver Disease
The genetic association between nonalcoholic fatty liver disease and type 2 diabetes mellitus in different body mass index categories： A bidirectional Mendelian randomization study
Haoxin DUAN, Yuyong JIANG, Tingyu WU, Feixiang XIONG, Yandan JIANG, Qin ZHANG, Saisai ZHAO, Hao YU
2024, 40(10): 1992-1999. DOI: 10.12449/JCH241011
Abstract(401) HTML (146) PDF (3023KB)(35)
Abstract:
Objective To investigate the genetic association between nonalcoholic fatty liver disease （NAFLD） and type 2 diabetes mellitus （T2DM） using bidirectional two-sample Mendelian randomization （MR）， as well as the causal relationship between NAFLD and T2DM across different body mass index （BMI） categori...
Effect of Bacillus licheniformis preparation on hepatic steatosis and intestinal mucosal barrier function in a rat model of nonalcoholic fatty liver disease
Chunyan ZHAO, Yiqun LI, Li LI
2024, 40(10): 2000-2007. DOI: 10.12449/JCH241012
Abstract(288) HTML (102) PDF (4213KB)(37)
Abstract:
Objective To investigate the effects of Bacillus licheniformis on liver histopathology and intestinal mucosal barrier function in rats with nonalcoholic fatty liver disease（NAFLD）. Methods A total of 30 male Sprague-Dawley rats were randomly divided into normal control group （Control group with 5 ra...
Liver Fibrosis and Liver Cirrhosis
Efficacy and safety of tenofovir alafenamide fumarate in patients with first-time hepatitis B virus-related decompensated cirrhosis
Xinxin RONG, Yuanyuan XU, Guangde YANG, Xia WANG, Juanjuan FU, Li LI, Xiucheng PAN
2024, 40(10): 2008-2013. DOI: 10.12449/JCH241013
Abstract(896) HTML (114) PDF (736KB)(97)
Abstract:
Objective To investigate the application value of tenofovir alafenamide fumarate （TAF） in patients with first-time hepatitis B virus-related decompensated cirrhosis （HBV-DC） and its impact on renal function and lipid metabolism. Methods A total of 57 patients with first-time HBV-DC who were hospital...
Liver Neoplasm
Efficacy of des-γ-carboxy-prothrombin in the diagnosis of hepatocellular carcinoma and its association with the clinical features of hepatocellular carcinoma
Zhi LIU, Xiaohong DU, Wengang CHAI
2024, 40(10): 2014-2018. DOI: 10.12449/JCH241014
Abstract(324) HTML (155) PDF (917KB)(64) Cited By (2)
Abstract:
Objective To investigate the value of des-γ-carboxy-prothrombin （DCP） in hepatocellular carcinoma （HCC）. Methods A retrospective analysis was performed for the clinical data of 179 HCC patients who were admitted to The First Hospital of Jilin University from January 2020 to July 2021， and 207 health...
Clinical features and prognosis of hepatocellular carcinoma： A single-center study of 850 cases
Meng REN, Yi YANG, Ziming LI, Renqian ZHANG, Yufeng SHI, Junxiu TAO
2024, 40(10): 2019-2026. DOI: 10.12449/JCH241015
Abstract(301) HTML (209) PDF (1142KB)(44) Cited By (2)
Abstract:
Objective To investigate the clinical features and prognosis of hepatocellular carcinoma （HCC）. Methods Medical records were collected from 850 HCC patients who were admitted to Hubei Provincial Hospital of Traditional Chinese Medicine from December 2014 to May 2022， and their clinical and prognosti...
Efficacy of transjugular intrahepatic portosystemic shunt in treatment of hepatocellular carcinoma comorbid with esophagogastric variceal bleeding
Xiang GAO, Xiaofeng ZHANG, Yimin CAO, Jinjun CHEN, Xiaoqin LUO
2024, 40(10): 2027-2033. DOI: 10.12449/JCH241016
Abstract(421) HTML (96) PDF (1038KB)(28)
Abstract:
Objective To investigate the efficacy of transjugular intrahepatic portosystemic shunt （TIPS） in preventing rebleeding in patients with hepatocellular carcinoma （HCC） comorbid with esophagogastric variceal bleeding and the influencing factors for prognosis. Methods A retrospective analysis was perfo...
Efficacy and safety of camrelizumab monoclonal antibody combined with molecular-targeted therapy in elderly patients with advanced hepatocellular carcinoma
Long CHENG, Yue ZHANG, Yushen LIU, Zhaoqing DU, Zhaoyang GUO, Yangwei FAN, Ting LI, Xu GAO, Enrui XIE, Zixuan XING, Wenhua WU, Yinying WU, Mingbo YANG, Jie LI, Yu ZHANG, Wen KANG, Wenjun WANG, Fanpu JI, Jiang GUO, Ning GAO
2024, 40(10): 2034-2041. DOI: 10.12449/JCH241017
Abstract(320) HTML (114) PDF (1217KB)(32)
Abstract:
Objective To investigate the efficacy and safety of camrelizumab monoclonal antibody combined with molecular-targeted therapy in elderly patients with unresectable or advanced hepatocellular carcinoma （HCC）. Methods A retrospective analysis was performed for the patients with unresectable/advanced H...
Differences and application value of plasma bile acids in tumors of the liver
Ru JIA, Pingping ZHANG, Yuan YUAN, Yiyang HU, Qin FENG
2024, 40(10): 2042-2048. DOI: 10.12449/JCH241018
Abstract(560) HTML (142) PDF (1078KB)(38)
Abstract:
Objective To investigate the levels of plasma bile acids （BA） in patients with primary liver cancer （PLC） or metastatic liver cancer （MLC） and their correlation with clinical indicators， as well as the value of plasma BAs combined with alpha-fetoprotein （AFP） in the diagnosis of PLC. Methods This st...
Regulatory effect of Kangxian Yiai Prescription in a rat model of precancerous lesions of liver cancer： A study based on the mTOR/HIF-1α/VEGF signaling pathway
Zhiguo LI, Xun MA, Yongan YE, Xianzhao YANG
2024, 40(10): 2049-2054. DOI: 10.12449/JCH241019
Abstract(531) HTML (135) PDF (1845KB)(30)
Abstract:
Objective To investigate the effect of Kangxian Yiai Prescription （KXYA） on the mTOR/HIF-1α/VEGF signaling pathway in a rat model of precancerous lesions of liver cancer. Methods A total of 40 male Wistar rats were divided into normal group， model group， KXYA group， and Biejia Rangan Tablets （BJRG） ...
Other Liver Disease
Causal association of liver function and lipid metabolism levels with sleep disorders based on Mendelian randomization
Wei HE, Shuke ZHU, Chunyu LI, Xue DU, Jiarui LI
2024, 40(10): 2055-2061. DOI: 10.12449/JCH241020
Abstract(287) HTML (105) PDF (2416KB)(40) Cited By (1)
Abstract:
Objective To investigate the causal association of liver function and lipid metabolism levels with sleep disorders based on the Mendelian randomization analysis. Methods The analysis was conducted using the data from genome-wide association studies， with the exposure factors of liver function and li...
Protective effect of folic acid against cholestatic liver injury in mice caused by bis（2-ethylhexyl） phthalate exposure
Mengzhen HOU, Yun YU, Qianqian HUANG, Lun ZHANG, Wenkang TAO, Yue JIANG, Jianqing WANG
2024, 40(10): 2062-2069. DOI: 10.12449/JCH241021
Abstract(246) HTML (142) PDF (3319KB)(35)
Abstract:
Objective To investigate the protective effect of folic acid against cholestatic liver injury in mice induced by bis（2-ethylhexyl） phthalate （DEHP） exposure and its mechanism. Methods ICR mice were randomly divided into control group， high-dose folic acid （H-FA） group， DEHP group， DEHP+low-dose foli...
Biliary Disease
Imaging features and therapeutic strategies for lethal iatrogenic hemobilia
Chen WANG, Min WANG, Ke ZHANG, Jinxing ZHANG, Li LIU, Zhining FAN
2024, 40(10): 2070-2074. DOI: 10.12449/JCH241022
Abstract(267) HTML (99) PDF (2026KB)(35)
Abstract:
Objective To investigate the imaging features and pathogenesis of lethal iatrogenic hemobilia （LIH） and the value of transarterial intervention in the treatment of LIH. Methods A total of 269 patients with upper gastrointestinal bleeding who were admitted to The First Affiliated Hospital of Nanjing ...
Case Report
The extreme reduction in cholinesterase caused by compound heterozygous mutations in the BCHE gene： A case report
Sa LYU, Bing ZHU, Tianjiao XU, Shaoli YOU
2024, 40(10): 2075-2078. DOI: 10.12449/JCH241023
Abstract(612) HTML (106) PDF (1397KB)(39)
Abstract:
Serum cholinesterase （ChE） level is important for the diagnosis and prognostic evaluation of various diseases such as liver diseases and toxic diseases， and butyrylcholinesterase （BuChE） is an important component of ChE. Mutations in the BCHE gene can cause a significant reduction in the level of Bu...
Pancreatic hamartoma： A case report
Quankai FENG, Jie LI
2024, 40(10): 2079-2081. DOI: 10.12449/JCH241024
Abstract(303) HTML (116) PDF (1146KB)(40)
Abstract:
Pancreatic hamartoma is a rare benign lesion of the pancreas characterized by a lack of typical clinical symptoms and imaging features， which leads to the difficulty in diagnosis before surgery. Since surgical intervention is often performed due to the inability to exclude the risk of malignant tumo...
Review
Therapeutic paradigms and potential therapies for nonalcoholic steatohepatitis
Feng LI, Maowei LI, Yushan WANG
2024, 40(10): 2082-2086. DOI: 10.12449/JCH241025
Abstract(294) HTML (309) PDF (723KB)(86)
Abstract:
In recent years， steady progress has been made in the epidemiology， pathogenesis， and therapeutic targets of nonalcoholic steatohepatitis （NASH）， while there has been slow progress in the field of therapeutic drug development. This article reviews the advances in lifestyle intervention， surgical met...
The role of CD8+ T cells in nonalcoholic steatohepatitis
Yiming ZHAO, Kaiyang LI, Mei YANG, Qi ZHAO
2024, 40(10): 2087-2091. DOI: 10.12449/JCH241026
Abstract(312) HTML (117) PDF (842KB)(38)
Abstract:
Nonalcoholic steatohepatitis （NASH） is a liver disease closely associated with metabolic syndrome， and its pathogenesis includes insulin resistance， lipid metabolism disorders， and inflammatory response. This article briefly describes how CD8+ T cells exert a cytotoxic effect through the three pathw...
Research advances in the mechanism of action of nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome in autoimmune hepatitis
Lifei WANG, Longlong LUO, Guojing XING, Lixia LU, Bin LI, Jiucong ZHANG, Xiaohui YU
2024, 40(10): 2092-2097. DOI: 10.12449/JCH241027
Abstract(277) HTML (154) PDF (1474KB)(32)
Abstract:
Autoimmune hepatitis （AIH） is chronic hepatitis caused by the attack of live cells by the immune system， and at present， the pathogenesis of AIH remains unclear. Inflammasomes are important components of innate immunity and are involved in a variety of pathophysiological processes. Studies have show...
High-risk factors for early postoperative recurrence of hepatocellular carcinoma and related prediction methods
Ye LU, Shaoshan HAN, Qingguang LIU
2024, 40(10): 2098-2103. DOI: 10.12449/JCH241028
Abstract(404) HTML (183) PDF (663KB)(94) Cited By (1)
Abstract:
Hepatocellular carcinoma （HCC） is a malignant tumor with high incidence and mortality rates， and although surgical resection is a possible method for cure， the prognosis of HCC is still affected by its high recurrence rate. Early recurrence （within 2 years after surgery） is defined as true recurrenc...
Role of statins in chronic liver disease
Xikun YANG, Hui LI, Zijian ZENG, Xuan WU, Kaixin WANG
2024, 40(10): 2104-2108. DOI: 10.12449/JCH241029
Abstract(398) HTML (111) PDF (649KB)(102)
Abstract:
Chronic liver disease is the “devil’s trilogy” in which the liver progresses from inflammation and fibrosis to liver cirrhosis and hepatocellular carcinoma， which poses a great challenge for hepatologists worldwide. Statins have played a significant role in the treatment of cardiovascular diseases a...
Recurrent hyperlipidemic acute pancreatitis： Etiology and prevention and treatment strategies
Lina QI, Ping CHEN
2024, 40(10): 2109-2115. DOI: 10.12449/JCH241030
Abstract(516) HTML (174) PDF (768KB)(47)
Abstract:
The incidence rate of hyperlipidemic acute pancreatitis （HLAP） is gradually increasing， with the features of young age， severe conditions， frequent recurrence， and poor prognosis， and recurrent HLAP has become a difficult issue that needs to be solved urgently in clinical practice. This article summ...
The association between gallstone and biliary pancreatitis
Weijia LI, Zhenfang LI, Qian ZHANG, Cong LI, Fengjiao WANG, Qi ZHAO
2024, 40(10): 2116-2120. DOI: 10.12449/JCH241031
Abstract(343) HTML (150) PDF (996KB)(76)
Abstract:
Acute pancreatitis is one of the most common acute abdominal diseases in clinical practice， and the common etiologies of acute pancreatitis include biliary diseases， alcohol， pancreatic duct diseases， metabolic disorders （hypertriglyceridemia and hypercalcemia）， excessive eating， and diseases of the...
Current status of the application of artificial intelligence in the diagnosis and treatment of pancreatic cancer
Yu MA, Feng JIA, Kaiyu LIU, Yahui LIU
2024, 40(10): 2121-2126. DOI: 10.12449/JCH241032
Abstract(827) HTML (241) PDF (728KB)(34)
Abstract:
Pancreatic cancer is a common malignant tumor of the digestive system， with a low early diagnosis rate， a high surgical mortality rate， a low cure rate， and a poor overall prognosis. In recent years， with the continuous development of artificial intelligence in the medical field， artificial intellig...
Current status and prospects of the application of Mendelian randomization in pancreatic cancer research
Kaihao DU, Lizhao HOU, Lanminghui LUO, Xiaoge DONG, Wei JIANG, Zhan WANG
2024, 40(10): 2127-2136. DOI: 10.12449/JCH241033
Abstract(349) HTML (163) PDF (1051KB)(34)
Abstract:
Pancreatic cancer often has an insidious onset and difficulties in treatment， with various limitations in early diagnosis and treatment. This article reviews the application of Mendelian randomization （MR） in exploring the risk factors for pancreatic cancer， with a special focus on the causal relati...
Introduction of High - quality Articles in Foreign Journals
MedComm｜Detection of minimal hepatic encephalopathy in patients with cirrhosis based on the Stroop-CN model (NCRCID-CHESS 2106): a prospective multicenter study
2024, 40(10): 2018-2018. DOI: 10.12449/JCH2410.gwqkjpwzjj1
Abstract(157) HTML (100) PDF (892KB)(13)
Abstract:
Hepatology｜Health-Related quality of life (HRQL) assessments in a 52-week, double-blind, randomized, placebocontrolled phase 3 study of resmetirom (MGL-3196) in patients with metabolic dysfunction associated steatohepatitis (MASH) and fibrosis
2024, 40(10): 2120-2120. DOI: 10.12449/JCH2410.gwqkjpwzjj2
Abstract(222) HTML (149) PDF (890KB)(27)
Abstract:
Journal of Hepatology｜Association of food insecurity with the prevalence and liver-related mortality of metabolic dysfunction-associated steatotic liver disease (MASLD)
2024, 40(10): 2126-2126. DOI: 10.12449/JCH2410.gwqkjpwzjj3
Abstract(143) HTML (114) PDF (900KB)(12)
Abstract:
Acknowledgements
Current reviewers
2024, 40(10): 2048-2048. DOI: 10.12449/JCH2410.zhixie
Abstract(109) HTML (60)
Abstract:
    

The first journal specializing in hepatobiliary and pancreatic diseases in China

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