Effect and mechanism of external therapy of traditional Chinese medicine in treatment of nonalcoholic fatty liver disease

Wenxia ZHAO; Peiwei YANG

doi:10.12449/JCH241003

Volume 40 Issue 10

Oct. 2024

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Effect and mechanism of external therapy of traditional Chinese medicine in treatment of nonalcoholic fatty liver disease

DOI: 10.12449/JCH241003

Wenxia ZHAO^{,
,},
Peiwei YANG

Department of Spleen，Stomach，Liver and Gallbladder，The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

Research funding:

National Natural Science Foundation of China Project (82205086);

Henan Province Double First Class Traditional Chinese Medicine Discipline Creation Project (STG-ZYX02-202117);

The Second National Famous Traditional Chinese Medicine Inheritance Studio Construction Project (National Medical Office Education Letter ［2022］ No.245)

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Corresponding author: ZHAO Wenxia， zhao-wenxia@163.com （ORCID： 0000-0002-0592-3504）
Received Date: 2024-07-29
Accepted Date: 2024-08-15
Published Date: 2024-10-25

Abstract

Abstract

Nonalcoholic fatty liver disease （NAFLD） is a common metabolic disease， and in recent years， the incidence rate of NAFLD is gradually increasing， which seriously threatens human health. As a traditional treatment method， external therapy of traditional Chinese medicine （TCM） has shown unique advantages and potential in the treatment of NAFLD. This article provides a detailed analysis of the TCM understanding of the etiology and pathogenesis of NAFLD， the application of TCM external therapy in clinical research， and the research on its therapeutic mechanism， in order to provide reference and guidance for further research in this field.
- Nonalcoholic Fatty Liver Disease,
- External Treatment,
- Medicine， Chinese Traditional

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References

[1]	MANTOVANI A, GATTI D, ZOPPINI G, et al. Association between nonalcoholic fatty liver disease and reduced bone mineral density in children: A meta-analysis[J]. Hepatology, 2019, 70( 3): 812- 823. DOI: 10.1002/hep.30538.
[2]	Branch of Hepatobiliary Diseases. Guidelines for the prevention and treatment of metabolic dysfunction-associated(non-alcoholic) fatty liver disease(Version 2024)[J]. J Prac Hepatol, 2024, 32( 5): 418- 434. DOI: 10.3760/cma.j.cn501113-20240327-00163. 中华医学会肝病学分会. 代谢相关(非酒精性)脂肪性肝病防治指南(2024年版)[J]. 实用肝脏病杂志, 2024, 27( 4): 494- 510. DOI: 10.3760/cma.j.cn501113-20240327-00163.
[3]	RINELLA ME, NEUSCHWANDER-TETRI BA, SIDDIQUI MS, et al. AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease[J]. Hepatology, 2023, 77( 5): 1797- 1835. DOI: 10.1097/HEP.0000000000000323.
[4]	LOU TW, YANG RX, FAN JG. The global burden of fatty liver disease: The major impact of China[J]. Hepatobiliary Surg Nutr, 2024, 13( 1): 119- 123. DOI: 10.21037/hbsn-23-556.
[5]	ZHAO WX. Guidelines for prevention and treatment of non-alcoholic simple fatty liver disease[J]. Chin J Integr Tradit West Med Liver Dis, 2024, 34( 1): attachI-VI. 赵文霞. 非酒精性单纯性脂肪性肝病治未病干预指南[J]. 中西医结合肝病杂志, 2024, 34( 1): 附I-VI.
[6]	Branch of Gastrointestinal Diseases, China Association of Chinese Medicine. Expert consensus on TCM diagnosis and treatment of nonalcoholic fatty liver disease(2017)[J]. J Clin Hepatol, 2017, 33( 12): 2270- 2274. DOI: 10.3969/j.issn.1001-5256.2017.12.002. 中华中医药学会脾胃病分会. 非酒精性脂肪性肝病中医诊疗专家共识意见(2017)[J]. 临床肝胆病杂志, 2017, 33( 12): 2270- 2274. DOI: 10.3969/j.issn.1001-5256.2017.12.002.
[7]	GU YJ, ZHAO WX. Effect of electroacupuncture on body mass index in obese non-alcoholic fatty liver[J]. Chin J Integr Tradit West Med Liver Dis, 2014, 24( 6): 338- 339, 346. DOI: 10.3969/j.issn.1005-0264.2014.06.006. 顾亚娇, 赵文霞. 电针疗法对肥胖型非酒精性单纯性脂肪肝患者体重指数的影响[J]. 中西医结合肝病杂志, 2014, 24( 6): 338- 339, 346. DOI: 10.3969/j.issn.1005-0264.2014.06.006.
[8]	HE YJ, HE JJ, FAN YS, et al. Analysis on acupoint selection rules in the treatment of metabolism-associated fatty liver disease based on data mining[J]. Acupunct Res, 2024, 49( 4): 424- 433. DOI: 10.13702/j.1000-0607.20221333. 贺煜竣, 何就杰, 范郁山, 等. 基于数据挖掘技术分析针灸治疗代谢相关脂肪性肝病的选穴规律[J]. 针刺研究, 2024, 49( 4): 424- 433. DOI: 10.13702/j.1000-0607.20221333.
[9]	DONG C, ZHANG CR, XUE BY, et al. Electroacupuncture combined with lifestyle control on obese nonalcoholic fatty liver disease: A randomized controlled trial[J]. Chin Acupunct Moxibustion, 2020, 40( 2): 129- 134. DOI: 10.13703/j.0255-2930.20190201-k0003. 董灿, 张彩荣, 薛博瑜, 等. 电针结合生活方式控制治疗肥胖型非酒精性脂肪性肝病: 随机对照研究[J]. 中国针灸, 2020, 40( 2): 129- 134. DOI: 10.13703/j.0255-2930.20190201-k0003.
[10]	HUA DL, LI DD, ZHUANG FL, et al. Correlation between the therapeutic efficacy of acupuncture in treating nonalcoholic fatty liver disease and needle-retaining time[J]. Shanghai J Acupunct Moxibustion, 2020, 39( 6): 687- 691. DOI: 10.13460/j.issn.1005-0957.2020.06.0687. 花冬兰, 李丹丹, 庄凤玲, 等. 针刺治疗非酒精性脂肪性肝病的疗效与留针时间的关系[J]. 上海针灸杂志, 2020, 39( 6): 687- 691. DOI: 10.13460/j.issn.1005-0957.2020.06.0687.
[11]	YANG X, HE BJ, SUN SQ, et al. Clinical effect of acupoint thread-embedding therapy at different intervals in the intervention of metabolic syndrome[J]. Acupunct Res, 2020, 45( 1): 62- 65, 73. DOI: 10.13702/j.1000-0607.180681. 杨璇, 贺边疆, 孙生琦, 等. 不同间隔时间穴位埋线干预代谢综合征的对比研究[J]. 针刺研究, 2020, 45( 1): 62- 65, 73. DOI: 10.13702/j.1000-0607.180681.
[12]	Branch of Hepatobiliary Diseases, Chinese Association of Chinese Medicine. Chinese medicine practice guide for acupoint catgut embedding in treating non-alcoholic fatty liver disease[J]. J Clin Hepatol, 2022, 38( 9): 1990- 1993. DOI: 10.3969/j.issn.1001-5256.2022.09.008. 中华中医药学会肝胆病分会. 穴位埋线治疗非酒精性脂肪性肝病中医实践指南[J]. 临床肝胆病杂志, 2022, 38( 9): 1990- 1993. DOI: 10.3969/j.issn.1001-5256.2022.09.008.
[13]	ZHOU FF, CHEN Y, CAI HL, et al. Observation on clinical efficacy of acupoint catgut embedding therapy on non-alcoholic fatty liver disease[J]. Acad J Shanghai Univ Tradit Chin Med, 2024, 38( 3): 45- 49. DOI: 10.16306/j.1008-861x.2024.03.007. 周峰峰, 陈羽, 蔡浩亮, 等. 穴位埋线治疗非酒精性脂肪性肝病的临床疗效观察[J]. 上海中医药大学学报, 2024, 38( 3): 45- 49. DOI: 10.16306/j.1008-861x.2024.03.007.
[14]	XIE WQ. Clinical observation of catgut embedding at acupoints in the treatment of severe nonalcoholic fatty lver disease[J]. J Jiangxi Univ Chin Med, 2022, 34( 4): 64- 66. 谢文强. 穴位埋线治疗重度非酒精性脂肪肝患者的临床疗效观察[J]. 江西中医药大学学报, 2022, 34( 4): 64- 66.
[15]	HUANG Z, SONG SL, TAN KP, et al. Observation on clinical effects of acupoint thread-embedding method for non-alcoholic fatty liver disease[J]. J Acupunct Tuina Sci, 2016, 14( 3): 186- 191. DOI: 10.1007/s11726-016-0922-6.
[16]	WANG Q, TENG JY, YAO M, et al. The therapeutic effect of acupoint embedding thread on simple obesity with phlegm dampness constitution combined with non-alcoholic fatty liver disease[J]. Chin J Integr Tradit West Med Liver Dis, 2020, 30( 5): 457- 459. DOI: 10.3969/j.issn.1005-0264.2020.05.024. 王芹, 滕金艳, 姚敏, 等. 穴位埋线治疗痰湿体质单纯性肥胖合并非酒精性脂肪肝的疗效[J]. 中西医结合肝病杂志, 2020, 30( 5): 457- 459. DOI: 10.3969/j.issn.1005-0264.2020.05.024.
[17]	ZHANG F. Clinical study on bronze needle with tiger-shaped tally for scraping combined with Yang-warming and spleen-fortifying decoction in treating non-alcoholic fatty liver disease[J]. Henan Tradit Chin Med, 2023, 43( 11): 1746- 1750. DOI: 10.16367/j.issn.1003-5028.2023.11.0337. 张峰. 虎符铜砭刮痧联合温阳健脾汤治疗非酒精性脂肪性肝病临床研究[J]. 河南中医, 2023, 43( 11): 1746- 1750. DOI: 10.16367/j.issn.1003-5028.2023.11.0337.
[18]	ZHANG F, FEI JL. Dicussion on the clinical effect of hufu Tongbian scraping in the treatment of non-alcoholic fatty liver disease[J]. Clin Med Eng, 2021, 28( 11): 1495- 1496. DOI: 10.3969/j.issn.1674-4659.2021.11.1495. 张峰, 费景兰. 虎符铜砭刮痧治疗非酒精性脂肪性肝病的临床效果探讨[J]. 临床医学工程, 2021, 28( 11): 1495- 1496. DOI: 10.3969/j.issn.1674-4659.2021.11.1495.
[19]	FEI JL, ZHANG F, CHEN Q, et al. Clinical observation of Hufu copper scraping combined with Huatan Qushi Huoxue prescription in the treatment of non-alcoholic fatty liver disease[J]. Chin J Integr Tradit West Med Liver Dis, 2022, 32( 4): 319- 322. DOI: 10.3969/j.issn.1005-0264.2022.04.009. 费景兰, 张峰, 陈茜, 等. 虎符铜砭刮痧联合化痰祛湿活血方治疗非酒精性脂肪性肝病[J]. 中西医结合肝病杂志, 2022, 32( 4): 319- 322. DOI: 10.3969/j.issn.1005-0264.2022.04.009.
[20]	FEI JL, LIU ST, CHEN Q, et al. Clinical observation on treating obese nonalcoholic fatty liver disease by the Hufu Tongbian scraping with hunger-free fasting therapy[J]. Clin J Chin Med, 2022, 14( 23): 58- 61. DOI: 10.3969/j.issn.1674-7860.2022.23.017. 费景兰, 刘素彤, 陈茜, 等. 虎符铜砭刮痧配合无饥饿禁食疗法治疗肥胖型非酒精性脂肪性肝病的临床观察[J]. 中医临床研究, 2022, 14( 23): 58- 61. DOI: 10.3969/j.issn.1674-7860.2022.23.017.
[21]	ZHANG W, LI HN, HAI XH, et al. Clinical study of kneading abdomen in treatment of non alcoholic fatty liver disease[J]. China Ind Econ, 2016, 43( 2): 286- 288. DOI: 10.13192/j.issn.1000-1719.2016.02.025. 张玮, 李华南, 海兴华, 等. 揉腹法治疗非酒精性脂肪肝的疗效研究[J]. 辽宁中医杂志, 2016, 43( 2): 286- 288. DOI: 10.13192/j.issn.1000-1719.2016.02.025.
[22]	ZHANG BX, LI DJ, LAN ZG, et al. The effect of abdominal massage on body mass index, waist hip ratio, and waist circumference in NAFLD patients[J]. Health Prot Promot, 2018( 4): 58- 59. DOI: 10.3969/j.issn.1671-0223(x).2018.04.045. 张宝霞, 李大军, 兰志刚, 等. 腹部推拿对NAFLD患者体质量指数、腰臀比、腰围的影响[J]. 现代养生(下半月版), 2018( 4): 58- 59. DOI: 10.3969/j.issn.1671-0223(x).2018.04.045.
[23]	ZHANG W, LI HN, ZHAO N, et al. Research ideas on abdominal massage therapy for non-alcoholic fatty liver disease based on the gut liver axis[J]. Liaoning J Tradit Chin Med, 2017, 44( 9): 1857- 1859. DOI: 10.13192/j.issn.1000-1719.2017.09.023. 张玮, 李华南, 赵娜, 等. 基于肠-肝轴浅谈腹部推拿治疗非酒精性脂肪肝病的研究思路[J]. 辽宁中医杂志, 2017, 44( 9): 1857- 1859. DOI: 10.13192/j.issn.1000-1719.2017.09.023.
[24]	GU YJ, ZHANG LH, ZHAO WX. Observation of the therapeutic effect of acupuncture combined with medication on non-alcoholic fatty liver disease[J/CD]. Electr J Clin Med Literat, 2019, 6( 96): 57- 58. 顾亚娇, 张丽慧, 赵文霞. 针刺配合药物对非酒精性脂肪肝疗效的观察[J/CD]. 临床医药文献电子杂志, 2019, 6( 96): 57- 58.
[25]	JIN Y, ZHANG YC, WANG XL. Discussion on the experience of acupuncture treatment of fatty liver guided by the theory of blood turbidity[J]. Tianjin J Tradit Chin Med, 2020, 37( 3): 270- 274. DOI: 10.11656/j.issn.1672-1519.2020.03.08. 金妍, 张永臣, 王新陆. 血浊理论指导针刺治疗脂肪肝的经验探讨[J]. 天津中医药, 2020, 37( 3): 270- 274. DOI: 10.11656/j.issn.1672-1519.2020.03.08.
[26]	YAN CC, MAO YF, JIN Y, et al. Experience in treatment of fatty liver with qi stagnation and blood stasis syndrome by acupuncture and medicine based on turbid blood theory[J]. J Tianjin Univ Tradit Chin Med, 2021, 38( 10): 1225- 1230. DOI: 10.11656/j.issn.1672-1519.2021.10.01. 颜纯淳, 毛逸斐, 金妍, 等. 基于血浊理论针药结合治疗气滞血瘀型脂肪肝经验[J]. 天津中医药, 2021, 38( 10): 1225- 1230. DOI: 10.11656/j.issn.1672-1519.2021.10.01.
[27]	HU XC, HUANG XD, YAN CC, et al. Clinical observation on the treatment of non-alcoholic fatty liver disease with“hand and foot twelve needles” combined with chinese herb decoction[J]. Tradit Chin Med J, 2019, 18( 1): 38- 42. 胡鑫才, 黄小冬, 颜纯钏, 等.“手足十二针” 联合中药治疗非酒精性脂肪肝的临床观察[J]. 中医药通报, 2019, 18( 1): 38- 42.
[28]	WANG Y, SONG L. The effects of modified Yinchenhao decoction combined with acupuncture on gut microbiota, oxidative stress, and cytokines in patients with non-alcoholic fatty liver disease[J]. Mod J Integr Tradit Chin West Med, 2023, 32( 8): 1119- 1122, 1126. DOI: 10.3969/j.issn.1008-8849.2023.08.017. 王艳, 宋丽. 加味茵陈蒿汤联合针刺对非酒精性脂肪肝患者肠道菌群、氧化应激及细胞因子的影响[J]. 现代中西医结合杂志, 2023, 32( 8): 1119- 1122, 1126. DOI: 10.3969/j.issn.1008-8849.2023.08.017.
[29]	YUAN SF, YE J, WANG LQ, et al. Clinical efficacy and safety of Jiangzhi Ligan Decoction combined with acupuncture in the treatment of nonalcoholic fatty liver disease[J]. China Mod Dr, 2022, 60( 15): 132- 135. 袁淑芬, 叶璟, 王丽琴, 等. 降脂理肝汤联合针刺治疗非酒精性脂肪肝临床疗效及安全性研究[J]. 中国现代医生, 2022, 60( 15): 132- 135.
[30]	CHEN YL, CHEN S, WANG JY, et al. Clinical observation of the treatment of non-alcoholic fatty liver disease with umbilical needling therapy[J]. Henan Tradit Chin Med, 2023, 43( 7): 1096- 1099. DOI: 10.16367/j.issn.1003-5028.2023.07.0218. 陈玉麟, 陈述, 王箭焱, 等. 脐针疗法治疗非酒精性脂肪性肝病临床观察[J]. 河南中医, 2023, 43( 7): 1096- 1099. DOI: 10.16367/j.issn.1003-5028.2023.07.0218.
[31]	LI Y, LIU XY, FANG J, et al. Clinic research of blood-letting puncture in the treatment of non-alcoholic fatty liver disease with syndrome of stagnation of liver qi and spleen deficiency combined with syndrome of intermingled phlegm and blood stasis[J]. China J Tradit Chin Med Pharm, 2016, 31( 11): 4871- 4875. 李玥, 刘新燕, 方金, 等. 刺络泻血治疗肝郁脾虚痰瘀互结型非酒精性脂肪性肝病的临床研究[J]. 中华中医药杂志, 2016, 31( 11): 4871- 4875.
[32]	FENG ST, LI C, SUN FF, et al. Cupping as assistant treatment in intervening non-alcoholic fatty liver disease[J]. Shanghai J Acupunct Moxibustion, 2017, 36( 12): 1411- 1414. DOI: 10.13460/j.issn.1005-0957.2017.12.1411. 冯舒婷, 李嫦, 孙风凡, 等. 拔罐辅助治疗非酒精性脂肪性肝病临床疗效观察[J]. 上海针灸杂志, 2017, 36( 12): 1411- 1414. DOI: 10.13460/j.issn.1005-0957.2017.12.1411.
[33]	LI HB, SUN P, CHEN Y, et al. Research on the intervention of NAFLD by Baduanjin[J]. J Chengdu Sport Univ, 2018, 44( 5): 79- 83, 90. DOI: 10.15942/j.jcsu.2018.05.013. 李华斌, 孙萍, 陈瑛, 等. 八段锦对非酒精性脂肪肝的干预研究[J]. 成都体育学院学报, 2018, 44( 5): 79- 83, 90. DOI: 10.15942/j.jcsu.2018.05.013.
[34]	YAO RR. Clinical study on acupoint embedding combined with ear pressure for the treatment of simple obesity with spleen deficiency and dampness excess type[D]. Kunming: Yunnan University of Traditional Chinese Medicine, 2023. 姚蓉蓉. 穴位埋线结合耳压治疗脾虚湿盛型单纯性肥胖的临床研究[D]. 昆明: 云南中医药大学, 2023.
[35]	CHEN ZQ, XIE YP, XU J, et al. Acupoint injection combined acupoint application treatment of non-alcoholic steatohepatitis with phlegm congestion syndrome[J]. Jilin J Chin Med, 2016, 36( 4): 419- 421. DOI: 10.13463/j.cnki.jlzyy.2016.04.030. 陈枝俏, 谢燕萍, 许娇, 等. 穴位注射联合贴敷治疗痰瘀型非酒精性脂肪肝[J]. 吉林中医药, 2016, 36( 4): 419- 421. DOI: 10.13463/j.cnki.jlzyy.2016.04.030.
[36]	ZHU YF, WU CL, YANG YH, et al. Efficacy observation of warm needling combined with Ba Duan Jin for non-alcoholic fatty liver disease[J]. Shanghai J Acupunct Moxibustion, 2020, 39( 12): 1525- 1529. DOI: 10.13460/j.issn.1005-0957.2020.12.1525. 朱云芳, 吴传莉, 杨雅红, 等. 温针灸联合八段锦治疗非酒精性脂肪肝病疗效观察[J]. 上海针灸杂志, 2020, 39( 12): 1525- 1529. DOI: 10.13460/j.issn.1005-0957.2020.12.1525.
[37]	ZHENG J. Observation of the clinical efficacy of massage and tapping exercises combined with ear acupressure intervention in patients with mild non-alcoholic fatty liver disease(damp turbidity syndrome)[J]. Guizhou Med J, 2022, 46( 3): 372- 373. DOI: 10.3969/j.issn.1000-744X.2022.03.014. 郑珏. 推拿拍打操联合耳穴贴压干预轻度非酒精性脂肪肝(湿浊内停证)患者的临床疗效观察[J]. 贵州医药, 2022, 46( 3): 372- 373. DOI: 10.3969/j.issn.1000-744X.2022.03.014.
[38]	YANG HJ, ZHANG M, WU S, et al. Effect of electroacupuncture on autophagy activity in the hypothalamus of insulin resistant rats[J]. Shanghai J Acupunct Moxibustion, 43( 4): 456- 463. DOI: 10.13460/j.issn.1005-0957.2024.04.0456. 杨鸿静, 张萌, 吴松, 等. 电针对胰岛素抵抗大鼠下丘脑自噬活性的影响[J]. 上海针灸杂志, 2024, 43( 4): 456- 463. DOI: 10.13460/j.issn.1005-0957.2024.04.0456.
[39]	LIU XX, ZHANG LZ, ZHANG HH, et al. Low-frequency electroacupuncture improves disordered hepatic energy metabolism in insulin-resistant Zucker diabetic fatty rats via the AMPK/mTORC1/p70S6K signaling pathway[J]. Acupunct Med, 2022, 40( 4): 360- 368. DOI: 10.1177/09645284211070301.
[40]	JIN SW, LIU JB, LI D, et al. Effect of Electroacupuncture at“Fenglong”(ST 40) on Liver Lipid Synthesis and Insulin Resistance in Hyperlipidemic Model Rats[J]. J Tradit Chin Med, 2023, 64( 22): 2346- 2353. DOI: 10.13288/j.11-2166/r.2023.22.014. 金舒文, 刘嘉宝, 李丹, 等. 电针“丰隆”穴对高脂血症模型大鼠肝脏脂质合成和胰岛素抵抗的影响[J]. 中医杂志, 2023, 64( 22): 2346- 2353. DOI: 10.13288/j.11-2166/r.2023.22.014.
[41]	JIA XY, LI MY, ZHANG W, et al.“ Adjusting internal organs and dredging channelon” electroacupuncture glycolipid metabolism disorders in NAFLD mice by mediating the AMPK/ACC signaling pathway[J]. Diabetol Metab Syndr, 2024, 16( 1): 173. DOI: 10.1186/s13098-024-01416-7.
[42]	WANG XC, ZHAO J, JIA BC, et al. Treatment of non-alcoholic fatty liver animal model with the acupuncture method of“soothing the liver and lowering cholesterol” and its therapeutic effect[J]. Chin J Gerontol, 2021, 41( 23): 5275- 5279. DOI: 10.3969/j.issn.1005-9202.2021.23.028. 王喜臣, 赵杰, 贾炳超, 等.“疏肝降脂”针法治疗非酒精性脂肪肝动物模型及疗效[J]. 中国老年学杂志, 2021, 41( 23): 5275- 5279. DOI: 10.3969/j.issn.1005-9202.2021.23.028.
[43]	HAN J, GUO X, MENG XJ, et al. Acupuncture improved lipid metabolism by regulating intestinal absorption in mice[J]. World J Gastroenterol, 2020, 26( 34): 5118- 5129. DOI: 10.3748/wjg.v26.i34.5118.
[44]	KARKUCINSKA-WIECKOWSKA A, SIMOES ICM, KALINOWSKI P, et al. Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationship[J]. Eur J Clin Invest, 2022, 52( 3): e13622. DOI: 10.1111/eci.13622.
[45]	WANG HY, LIANG CM, CUI JW, et al. Acupuncture improves hepatic lipid metabolism by suppressing oxidative stress in obese nonalcoholic fatty liver disease rats[J]. Acupunct Res, 2019, 44( 3): 189- 194, 215. DOI: 10.13702/j.1000-0607.180650. 王海英, 梁翠梅, 崔静文, 等. 针刺通过抑制肝脏氧化应激改善腹型肥胖型非酒精性脂肪肝病大鼠的肝脏脂质代谢[J]. 针刺研究, 2019, 44( 3): 189- 194, 215. DOI: 10.13702/j.1000-0607.180650.
[46]	YUE PP, ZHANG WM, YANG D, et al. Effect of acupuncture therapy on oxidative stress and lipid levels in rats with hyperlipidemia based on the Nrf2/Keap1/HO-1 signaling pathway[J]. J Changchun Univ Chin Med, 2023, 39( 11): 1207- 1210. DOI: 10.13463/j.cnki.cczyy.2023.11.006. 岳盼盼, 张为民, 杨东, 等. 基于Nrf2/Keap1/HO-1信号通路探究针刺疗法对高脂血症大鼠氧化应激与脂质水平的影响[J]. 长春中医药大学学报, 2023, 39( 11): 1207- 1210. DOI: 10.13463/j.cnki.cczyy.2023.11.006.
[47]	WANG XH, GAO ZF. Study on the correlation between the severity of non-alcoholic fatty liver disease and inflammatory factors in patients[J]. Exp Lab Med, 2021, 39( 5): 1159- 1160, 1171. DOI: 10.3969/j.issn.1674-1129.2021.05.034. 王宪红, 高志峰. 非酒精性脂肪肝患者病情严重程度与炎性因子的相关性研究[J]. 实验与检验医学, 2021, 39( 5): 1159- 1160, 1171. DOI: 10.3969/j.issn.1674-1129.2021.05.034.
[48]	WANG HY, WANG Q, LIANG CM, et al. Acupuncture improved hepatic steatosis in HFD-induced NAFLD rats by regulating intestinal microbiota[J]. Front Microbiol, 2023, 14: 1131092. DOI: 10.3389/fmicb.2023.1131092.
[49]	MA BQ, LI P, AN HY, et al. Electroacupuncture attenuates liver inflammation in nonalcoholic fatty liver disease rats[J]. Inflammation, 2020, 43( 6): 2372- 2378. DOI: 10.1007/s10753-020-01306-w.
[50]	WEI DL, ZHAO HL, ZENG R, et al. Effects of blood-pricking therapy on inflammatory cytokines IL-6, IL-18 and TNF-α of nonalcoholic fatty liver disease[J]. China J Tradit Chin Med Pharm, 2018, 33( 4): 1631- 1633. 魏丹蕾, 赵慧玲, 曾蕊, 等. 刺络泻血疗法对非酒精性脂肪肝病相关炎性因子IL-6、IL-18、TNF-α的影响[J]. 中华中医药杂志, 2018, 33( 4): 1631- 1633.
[51]	HOU HT, QIU YM, ZHANG J, et al. GLP-1 down-regulates mRNA expression of SOCS-3 and SREBP-1c in rats with nonalcoholic fatty liver disease[J]. Chin J Pathophysiol, 2016, 32( 7): 1312- 1316. DOI: 10.3969/j.issn.1000-4718.2016.07.026. 侯洪涛, 裘艳梅, 张建, 等. GLP-1下调非酒精性脂肪肝大鼠SOCS-3和SREBP-1c的表达[J]. 中国病理生理杂志, 2016, 32( 7): 1312- 1316. DOI: 10.3969/j.issn.1000-4718.2016.07.026.
[52]	LUO A, YU M, LI G, et al. Effects of electroacupuncture of different intensities and durations on PERK/ATF4/CHOP signaling pathway in liver of non-alcoholic fatty liver disease rats[J]. Acupunct Res, 2024, 49( 4): 358- 366. DOI: 10.13702/j.1000-0607.20230097. 罗翱, 余敏, 李钢, 等. 不同强度及时程电针干预对非酒精性脂肪肝病大鼠肝脏PERK/ATF4/CHOP通路的影响[J]. 针刺研究, 2024, 49( 4): 358- 366. DOI: 10.13702/j.1000-0607.20230097.
[53]	YU M, LI G, TANG CL, et al. Effect of electroacupunctrue stimulation at\“fenglong\”(ST 40) on expression of SREBP-1 c in non-alcoholic fatty liver disease rats[J]. Acupunct Res, 2017, 42( 4): 308- 314. DOI: 10.13702/j.1000-0607.2017.04.005. 余敏, 李钢, 唐成林, 等. 电针“丰隆”穴对非酒精性脂肪肝大鼠肝组织固醇调节元件结合蛋白-1 c的影响[J]. 针刺研究, 2017, 42( 4): 308- 314. DOI: 10.13702/j.1000-0607.2017.04.005.
[54]	CHU YQ, CHU XF. Application of laboratory animals in the study of intestinal flora and nonalcoholic fatty liver disease[J]. Lab Anim Sci, 2023, 40( 1): 87- 92. DOI: 10.3969/j.issn.1006-6179.2023.01.018. 褚燕青, 褚晓峰. 实验动物在肠道菌群与非酒精性脂肪肝病研究中的应用[J]. 实验动物科学, 2023, 40( 1): 87- 92. DOI: 10.3969/j.issn.1006-6179.2023.01.018.
[55]	GAO LQ, SI YC, KANG ZX, et al. Effect of electroacupuncture on nutritional obese mice based on TLR5-gut microbiota pathway[J]. Acta Med Univ Sci Technol Huazhong, 2024, 53( 3): 321- 327. DOI: 10.3870/j.issn.1672-0741.23.10.017. 高璐琪, 司原成, 康朝霞, 等. 基于TLR5-肠道菌群途径探讨电针对营养型肥胖小鼠的作用机制[J]. 华中科技大学学报(医学版), 2024, 53( 3): 321- 327. DOI: 10.3870/j.issn.1672-0741.23.10.017.
[56]	ZHOU ZM, ZHANG JM, ZHOU H, et al. Synergistic and antagonistic effects of catgut embedding at ST40 and its matching points in NAFLD rats based on metabolomics[J]. J Clin Acupunct Moxib, 2024, 40( 6): 84- 90. DOI: 10.19917/j.cnki.1005-0779.024120. 周遵明, 张建梅, 周宏, 等. 基于代谢组学研究埋线丰隆及其配穴对NAFLD大鼠的协同和拮抗作用[J]. 针灸临床杂志, 2024, 40( 6): 84- 90. DOI: 10.19917/j.cnki.1005-0779.024120.
[57]	ZHONG XY, TANG CL, YU M. Regulation of electroacupuncture on non-canonical pathway of hepatocellular pyroptosis in rats with nonalcoholic fatty liver disease[J]. Chin Acupunct Moxibustion, 2024, 44( 5): 539- 545. DOI: 10.13703/j.0255-2930.20230206-k0001. 钟馨仪, 唐成林, 余敏. 电针对非酒精性脂肪性肝病大鼠肝细胞焦亡非经典途径的调控作用研究[J]. 中国针灸, 2024, 44( 5): 539- 545. DOI: 10.13703/j.0255-2930.20230206-k0001.

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Effect and mechanism of external therapy of traditional Chinese medicine in treatment of nonalcoholic fatty liver disease

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Effect and mechanism of external therapy of traditional Chinese medicine in treatment of nonalcoholic fatty liver disease

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