Causal association of liver function and lipid metabolism levels with sleep disorders based on Mendelian randomization

Wei HE; Shuke ZHU; Chunyu LI; Xue DU; Jiarui LI

doi:10.12449/JCH241020

Volume 40 Issue 10

Oct. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(10): 2055-2061

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Causal association of liver function and lipid metabolism levels with sleep disorders based on Mendelian randomization

DOI: 10.12449/JCH241020

Wei HE^{1
,
,
,},
Shuke ZHU²,
Chunyu LI²,
Xue DU²,
Jiarui LI²

1.
Department of Encephalopathy，Changchun Hospital of Traditional Chinese Medicine，Changchun 130000，China
2.
College of Traditional Chinese Medicine，Changchun University of Chinese Medicine，Changchun 130000，China

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Corresponding author: HE Wei， 297378127@qq.com （ORCID： 0009-0009-5281-734X）
Received Date: 2024-01-27
Accepted Date: 2024-05-23
Published Date: 2024-10-25

Abstract

Abstract

Objective To investigate the causal association of liver function and lipid metabolism levels with sleep disorders based on the Mendelian randomization analysis. Methods The analysis was conducted using the data from genome-wide association studies， with the exposure factors of liver function and lipid metabolism levels （alanine aminotransferase ［ALT］， aspartate aminotransferase ［AST］， gamma-glutamyl transpeptidase ［GGT］， albumin ［Alb］， serum total protein ［TP］， total bilirubin ［TBil］， alkaline phosphatase ［ALP］， triglyceride ［TG］， triglyceride-to-glycerol-3-phosphate ［TG/G3P］ ratio， total cholesterol ［TC］， high-density lipoprotein cholesterol ［HDL-C］， low-density lipoprotein cholesterol ［LDL-C］， poly-unsaturated fatty acids ［PUFA］， total fatty acids ［TFA］， PUFA/TFA ratio） and the outcome factor of sleep disorders （nonorganic）. The regression models including inverse variance weighted， MR-Egger， Simple mode， weighted median， and Weighted mode were used to perform the Mendelian randomization analysis. Results Serum Alb （odds ratio ［OR］=0.728， 95% confidence interval ［CI］： 0.535 ‍—‍‍ 0.989， P<0.05）， HDL-C （OR=0.879， 95%CI： 0.784 ‍—‍ 0.986， P<0.05）， and PUFA/TFA ratio （OR=0.800， 95%CI： 0.642 — 0.998， P<0.05） were negatively associated with sleep disorders， while TG/G3P ratio （OR=1.222， 95%CI： 1.044 ‍—‍ 1.431， P<0.05） was positively associated with sleep disorders. The results of Mendelian randomization did not show a causal association of ALT， AST， GGT， TP， TBil， ALP， TG， TC， LDL-C， PUFA， and TFA with sleep disorders （all P>0.05）. The results of the MR-Egger intercept test showed no pleiotropy （P>0.05）， and Mendelian randomization was a valid method for causal inference in this study. Conclusion According to the results of the Mendelian randomization analysis， liver function and lipid metabolism show significant association with sleep disorders. Liver function and lipid metabolism can be used as indicators for predicting the risk of sleep disorders and performing intervention.
- Liver Function,
- Lipid Metabolism,
- Sleep Disorders,
- Mendelian Randomization Analysis

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References

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Causal association of liver function and lipid metabolism levels with sleep disorders based on Mendelian randomization

DOI: 10.12449/JCH241020

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Causal association of liver function and lipid metabolism levels with sleep disorders based on Mendelian randomization

DOI: 10.12449/JCH241020

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