Expression of histone deacetylase 1 and matrix metalloproteinase-2 in hepatocellular carcinoma and its significance

Objective To study the expression of HDAC1 and MMP-2 in liver tissues of patients with hepatocellular carcinoma (HCC) and its significance.Methods Immunohistochemical analysis was used to detect the expression of HDAC1 and MMP-2 in 42 cases of HCC.Results The positive rate of HDAC1 and MMP-2 was significantly higher in HCC than that in para-cancerous tissues (P<0.01, P<0.05) , the expression of HDAC1 was not associated with patients′ gender, age, tumor size, alpha fetoprotein, histological grade and vessel embolus (P>0.05) , but was significantly associated with patients′ TNM stage (P<0.05) , the expression of MMP-2 was not associated with patient gender, age, tumor size, alpha fetoprotein, histological grade (P>0.05) , but was significantly associated with patient vessel embolus and TNM staging (P<0.05, P<0.01) , HDAC1 was positively correlated with MMP-2 expression in HCC.Conclusion In HCC tissues, increased HDAC1 and MMP-2 expression may associate to the hepatocarcinogenesis, and may indicate the status of advanced TNM stage.