Comparative detection of vitamin C and oxidative damage index levels in serum of patients with different clinical types of hepatitis B

Zhu XiaoYan; Song AnLin; Zhao YingRen

Issue 5

May 2011

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > Journal of Clinical Hepatology > 2011 > 27(5): 503-504+507

PDF( 2638 KB)

Comparative detection of vitamin C and oxidative damage index levels in serum of patients with different clinical types of hepatitis B

Published Date: 2011-05-20

Abstract

Abstract

Objective To detect vitamin C levels and other indicators of oxidative damage in serum of patients with different clinical types of hepatitis B, and toprovide reference for use of Vitamin C in hepatitis B patients.Methods 45 cases of hepatitis B patients of which 20 patients were severe chronic hepatitis B patients, 15 cases were of compensated liver cirrhosis, 10 cases were of severe hepatitis, and 15 healthy patients as control group were included in the study.Vitamin C, malondialdehyde and total antioxidation were measured by ultraviolet spectrophotometry.Results (1) Compared with the healthy control group, vitamin C and total antioxidant capacity in hepatitis B patients' serum were significantly decreased (P<0.05) .Different clinical types have significant differences: severe hepatitis group < chronic hepatitis < cirrhosis group < normal group (P<0.05) .Hepatitis B groups' malondialdehyde level was significantly higher than that in the healthy control group (P<0.05) : severe hepatitis group > chronic hepatitis > liver sclerosis group > control group (P<0.05) . (2) The concentration of vitamin C in hepatitis B patients' serum was positively correlated with total antioxidant capacity and was negatively correlated with MDA.Conclusion The vitamin C level and total antioxidant capacity in hepatitis B patients' serum were significantly lower than that in the healthy control group, and MDA content was significantly increased.The concentration of vitamin C was positively correlated with total antioxidant capacity and was negatively correlated with MDA.
- hepatitis B,
- ascorbic acid,
- malondialdehyde

FullText(HTML)

References(10)

References

[1]葛颖华, 钟晓明.维生素C和维生素E抗氧化机制及其应用的研究进展[J].吉林医学, 2007, 29 (5) :93.

[2]Yamamoto Y, Yamashita S.Plasma ubiquinone to ubiquinol ratio in patients with hepatitis, cirrhosis, and hepatoma, and in patients treated with percutaneous transluminal coronary reperfusion[J].BioFactors, 9 (2-4) :241-246.

[3]中华医学会.病毒性肝炎防治方案[J].中华传染病杂志, 2001, 19 (1) :56-62.

[4]杨芳芳.抗坏血酸的测定方法[J].甘肃科技纵横, 2005, 34 (6) :208-209.

[5]Rigamonti C, Mottaran E, Reale E, et al.Moderate alcohol consumption increases oxidative stress in patients with chronic hepatitis C[J].Hepatology, 2003, 38 (1) :42-49.

[6] 王淑霞, 王凯, 韩捷, 等.慢性乙型肝炎患者血清维生素C含量与血清总胆红素水平的关系研究[C].第二届传染病诊治高峰论坛暨2009年浙江省感染病、肝病学术年会议论文汇编, 2009:89-90.

[7]钱燕春, 资源, 毛山山, 等.慢性乙型肝炎患者肝组织和外周血白细胞中钠离子依赖性维生素C转运体的表达[J].生命科学研究, 2009, 13 (6) :512-516.

[8]胡大林, 廖建坤.自由基与DNA的氧化损伤[J].国外医学 (卫生学分册) , 2002, 29 (5) :261-263.

[9]曹治宸, 白玉, 裴秀, 等.病毒性肝炎与铁代谢的研究近况[J].国外医学内科学分册, 2002, 29 (3) :100-103.

[10]Demirdag K, Yilmaz S, Ozdarendeli A, et al.Levels of plasma malondialdehyde and erythrocyte antioxidant enzyme activities in patients with chronic hepatitis B[J].Hepatogastroenterol, 2003, 50 (51) :766-770.

Relative Articles

[1]	Gao XiaoHong, Cheng Ni, Cao JiaoJiao. Clinical cure in patients with hepatitis B cirrhosis treated with pegylated interferon α-2b: A case report[J]. Journal of Clinical Hepatology, 2020, 36(6): 1347-1348. doi: 10.3969/j.issn.1001-5256.2020.06.031
[2]	Xu Jing, Ji Dong, Wang ChunYan, Fu YiMing, Chen SongHai, Li ZhongBin, Chen GuoFeng. Clinical significance of the change in plasma D-dimer in patients with hepatitis B cirrhosis[J]. Journal of Clinical Hepatology, 2020, 36(3): 551-555. doi: 10.3969/j.issn.1001-5256.2020.03.016
[3]	Deng YongDong, Peng XueBin, Yao LiQiong, Li Hai, Tan BangYun, Ma ChaoQun. Changes in procoagulant and anticoagulant factors in patients with hepatitis B cirrhosis[J]. Journal of Clinical Hepatology, 2019, 35(2): 345-348. doi: 10.3969/j.issn.1001-5256.2019.02.020
[4]	Bai ZhiQin, Song HuiYing, Wu RuiQing, Gao Dong, Huo HongMin, Yang Jing, Chen Shu. Effect of Buqi Huoxue decoction on hemodynamics and liver fibrosis indices in hepatitis B patients with cirrhotic portal hypertension[J]. Journal of Clinical Hepatology, 2017, 33(2): 272-276. doi: 10.3969/j.issn.1001-5256.2017.02.013
[5]	Zheng DongChun, Nie YuanXia, Liang HaiLin, Hu YueLin, Cheng Xiao, Feng XiaoXia, Chen YongPing. Epidemiological features and serological changes in sporadic acute hepatitis B among adults: an analysis of 202 cases[J]. Journal of Clinical Hepatology, 2014, 30(1): 30-33. doi: 10.3969/j.issn.1001-5256.2014.01.009
[6]	Zhang XueHua, Li ZhongPing. Changes in serum complement components after 48 weeks of entecavir treatment in hepatitis B cirrhosis patients[J]. Journal of Clinical Hepatology, 2013, 29(5): 339-342+347.
[7]	Zhang ZhanQing, Lu Wei, Wang YanBing, Jia XiaoFang, Zhang LiJun, Ding RongRong, Zhou XinLan, Feng YanLing. Diagnosis of hepatic fibrosis in hepatitis B patients by logistic regression modeling based on plasma amino acid ratio and age[J]. Journal of Clinical Hepatology, 2013, 29(5): 330-335.
[8]	Cao Xiao, Cao QingBao, Zhang GuoQiang, Chang ZaiJuan, Li ShuPing, Xu WeiWei. Analysis of occult hepatitis B virus infection among blood donors in Tangshan, China[J]. Journal of Clinical Hepatology, 2013, 29(2): 117-119.
[9]	Hu QiJiang, Jiang YingAn. Evaluation of the therapeutic efficacy of lamivudine combined with plasma exchange for treating acute-on-chronic hepatitis B liver failure [J]. Journal of Clinical Hepatology, 2013, 29(2): 107-109.
[10]	Wang XiangHuai, Ye YiNong, Liang MinFeng, Lin XiaoQing, Liu QuanMei, Bai HongLian, Long Hui, Yan HaiMing, Sun Jing, Yang Guang. Plasma exchange combined with hemofiltration influences serum levels of IL-17 and IL-6 in patients with HBV-related acute-on-chronic liver failure[J]. Journal of Clinical Hepatology, 2012, 28(10): 756-759+763.
[11]	Li Lei, Han Ying, Ping ChunXia, Ding HuiGuo. Prognostic value of noninvasive cardiac hemodynamics detection in patients with chronic hepatitis B-induced cirrhosis[J]. Journal of Clinical Hepatology, 2012, 28(9): 667-670.
[12]	Zhang ZhiHong, Ni BingQiang, Chen RiXin. Protective effect of Ornithine Aspartate on chemotherapy of gastrointestinal tumors with HBV infection[J]. Journal of Clinical Hepatology, 2011, 27(2): 148-150+160.
[13]	Zuo WeiZe, Xu ChunMei, Shen LanChao. Changes in serum level of interleukin-32 and interleukin-6 in patients with chronic hepatitis B virus infection and its clinical significance[J]. Journal of Clinical Hepatology, 2011, 27(4): 408-410+413.
[14]	Zhao YanJuan, Ye ChunYan, Song XiaoDan. The change in serum thyroid hormone levels in acute hepatitis B[J]. Journal of Clinical Hepatology, 2011, 27(2): 161-162+165.
[15]	Qi WenYue, Wang Yu, Liu Ya. The effect of Bicyclol on serum malondialdehyde levels in patients with chronic hepatitis B[J]. Journal of Clinical Hepatology, 2011, 27(2): 151-153.
[16]	Zhou XiuYun, Chen YingHua. Study on the relationship between liver histology and serological indexes in 50 cases of hepatitis B virus carriers [J]. Journal of Clinical Hepatology, 2010, 26(5): 508-509.
[17]	Shi YanMei, Lan YingHua, Dan Lei, Zhou Jin, Li YongGuo. The relationship between of hematopoietic stem cells and hepatitis B virus infection[J]. Journal of Clinical Hepatology, 2010, 26(4): 377-380.
[18]	Li Qiang, Chen Ming, Wang LiPing, Pan XiuCheng, Li ZhiYong. Relationship between serum Iron、Ferritin and lipid peroxidation injury in patients with chronic hepatitis B.[J]. Journal of Clinical Hepatology, 2008, 24(3): 183-185.

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views (4012) PDF downloads(843)

Comparative detection of vitamin C and oxidative damage index levels in serum of patients with different clinical types of hepatitis B

Abstract

References

Relative Articles

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Comparative detection of vitamin C and oxidative damage index levels in serum of patients with different clinical types of hepatitis B

Abstract

References

Relative Articles

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

About Journal

Submission Guideline

Journal Online

Hepatobiliary College

Guidelines

Export File

Citation

Format

Content