中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 3
Mar.  2006

S100A4和E-Cadherin在胰腺癌组织中的表达及相关性研究

  • Published Date: 2006-03-20
  • To investigate the relationship between S100A4 and E-Cadherin expression in the pancreatic cancer and their correlation with tumor invasion and metastasis.Immunohistochemistry was used to detect the expression of S100A4 and E-Cadherin in the tissue microarray constructed with 168 cases of pancreatic cancers.The positive expression of S100A4 and E-Cadherin in the cancer tissue were 82.74% (139/168) and 65.4% (110/168) respectively.S100A4 expression rate was 9.8% (10/102) in tissue and was 57% (4/7) in mucinous cystic adenoma.E-Cadherin expressed in all the Para-tumor tissue and normal pancreas, but only 30% (2/7) expressed in mucinous cystic adenoma.The expression of S100A4 and E-Cadherin had a closely relation in pancreatic cancer.S100A4 always overexpresses in the pancreatic ductal carcinoma and reflects the invasion and lymphomatic metastasis of tumors.It also is related with the down-regulation of E-Cadherin.

     

  • [1] Mazzuccheli L.Protein S100A 4∶too long overlooked by patholo-gists?[J].Am J Pathol, 2002, 160 (1) ∶7-13.
    [2] G ribenko AV, HopperJE, Makhatadze, G I, et al.Molecu lar charac-terization and tissue d istribution of a novelm ember, of the S100fam ilyof E.F-band proteins[J].B iochem istry, 2001, 40 (51) ∶15538-15548.
    [3]倪灿荣, 李芳梅, 朱明华, 等.提高组织芯片切片成功率的方法和体会[J].中华病理学杂志, 2002;31 (6) ∶559-560.
    [4] Rosty C, Uek i T, Argan i P, et al.Overexpression of S100A4in pan-creatic ductal adenocarcinomas is associated w ith poor d ifferentiationand DNA hypom ethlation[J].Am J Pathol, 2002, 160∶45-50.
    [5] Sherbet GV, Lakshm i MS.S100A4 (M IS1) calcium b ind ing proteinin cancer growth, invasion and m etastasis[J].Anticancer Res, 1998;18 (4A0∶2415-2421.
    [6] Donato R.S100:a mu ltigen ic fam ily of calcrum modu lated proteins ofthe EF-hand type w ith intracellu lar functional roles[J].Int J B io-chem Cell B iol, 2001, 33 (7) ∶637-668.
    [7] Mazzuccheli L.Protein S100A4:too long overlooked by pathologists[J].Am J Pathol, 2002, 160 (1) ∶7-13.
    [8] K imuraK, Endo Y, Yonemura Y, et al.C lin ical sign ificance of S100A4and E-cadherin related adhesion modecu les in non-small celllung cancer[J].Int J Oncol, 2000, 16 (6) ∶1125-1131.
    [9] Rud land PS, P lant-H iggints A, Renshaw C, et al.prognostic sig-n ificance of the m etastasis-inducing protein S100A4 (p9ka) in hu-man breast cancer[J].Cancer Res, 2000, 60∶1595-1603.
    [10] Yonemura Y, Endou Y, K imuraK, et al.Inverse expression of S100A4and E-cadherin is associated w ith m etastatic potential in gastriccancer[J].C lin Cancer Res, 2000, 6∶4234-4242.
    [11] Takenaga K, Nakan ish iH, W ada K, et al.increased expression ofS100A4, a m etastasis-associated gene, in human colorectal adeno-carcinomas[J].C lin Cancer Res, 1997, 3∶2309-2316.
    [12] N inom iya I, Ohta T, Fush isa S, et al.Increased expression of S100A4and its prognostic sign ificance in esophageal squamous cell carci-noma[J].Int J Oncol, 2001, 18∶715-720.
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