中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 35 Issue 10
Oct.  2019
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Article Contents

Value of contrast-enhanced endoscopic ultrasonography in the differential diagnosis of mass-type chronic pancreatitis and pancreatic cancer:A Meta-analysis

DOI: 10.3969/j.issn.1001-5256.2019.10.023
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  • Received Date: 2019-06-04
  • Published Date: 2019-10-20
  • Objective To systematically evaluate the value of contrast-enhanced endoscopic ultrasonography(CE-EUS) in the differential diagnosis of mass-type chronic pancreatitis and pancreatic cancer. Methods CNKI,Wanfang Data,CBM,PubMed,Embase,and the Cochrane Library were searched for Chinese and English articles on the value of CE-EUC in the differential diagnosis of mass-type chronic pancreatitis and pancreatic cancer published up to December 31,2018. Secondary screening,scoring,and data extraction were performed,and then Meta-Disc1. 4 and stata12. 0 software were used for meta-analysis. Results A total of 20 articles with 1888 patients were included in this study. The meta-analysis showed that in the differential diagnosis of mass-type chronic pancreatitis and pancreatic cancer,CE-EUS had a pooled sensitivity of 86%(95% confidence interval [CI]: 83%-89%),a specificity of 93%(95% CI: 92%-95%),a positive likelihood ratio of 12. 01(95% CI: 9. 72-14. 85),a negative likelihood ratio of 0. 16(95% CI: 0. 10-0. 26),a diagnostic odds ratio of 76. 12(95% CI: 54. 50-106. 31),and an area under the summary receiver operating characteristic curve of 0. 965 5. No sources of heterogeneity were found in the threshold effect test,the meta-regression analysis,and the sensitivity analysis. After the four articles causing heterogeneity were excluded,the heterogeneity of all included articles was reduced to an acceptable range,and there were no significant changes in the results of the meta-analysis. Conclusion CE-EUS has a good value in the differential diagnosis of mass-type chronic pancreatitis and pancreatic cancer,and its application in clinical practice can improve the diagnostic rate of pancreatic cancer.

     

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  • [1] WHITING P,RUTJES AW,REITSMA JB,et al. The development of QUADAS:A tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews[J].BMC Med Res Methodol,2003,3:25.
    [2] HOCKE M,SCHMIDT C,ZIMMER B,et al. Contrast enhanced endosonography for improving differential diagnosis between chronic pancreatitis and pancreatic cancer[J]. Dtsch Med Wochenschr,2008,133(38):1888-1892.
    [3] SAKAMOTO H,KITANO M,SUETOMI Y,et al. Utility of contrast-enhanced endoscopic ultrasonography for diagnosis of small pancreatic carcinomas[J]. Ultrasound Med Biol,2008,34(4):525-532.
    [4] S AˇFTOIU A,IORDACHE SA,GHEONEA DI,et al. Combined contrast-enhanced power Doppler and real time sonoelastography performed during EUS,used in the differential diagnosis of focal pancreatic masses(with videos)[J]. Gastrointest Endosc,2010,72(4):739-747.
    [5] FUSAROLI P,SPADA A,MANCINO MG,et al. Contrast harmonic echo-endoscopic ultrasound improves accuracy in diagnosis of solid pancreatic masses[J]. Clin Gastroenterol Hepatol,2010,8(7):629-634,e621-e622.
    [6] MATSUBARA H,ITOH A,KAWASHIMA H,et al. Dynamic quantitative evaluation of contrast-enhanced endoscopic ultrasonography in the diagnosis of pancreatic diseases[J]. Pancreas,2011,40(7):1073-1079.
    [7] GINCUL,R. Contrast-enhanced harmonic ultrasound(CEH-EUS)in diagnosis of pancreatic adenocarcinoma(ADK):Results of the first multicenter prospective study with intraand inter-observer concordances evaluation[J]. Gastrointestinal Endoscopy,2011,73(4):128.
    [8] KITANO M,KUDO M,YAMAO K,et al. Characterization of small solid tumors in the pancreas:The value of contrast-enhanced harmonic endoscopic ultrasonography[J]. Am J Gastroenterol,2012,107(2):303-310.
    [9] IMAZU H,KANAZAWA K,MORI N,et al. Novel quantitative perfusion analysis with contrast-enhanced harmonic EUS for differenti ation of autoimmune pancreatitis from pancreatic carcinoma[J]. Scand J Gastroenterol,2012,47(7):853-860.
    [10] GHEONEA DI,STREBA CT,CIUREA T,et al. Quantitative low mechanical index contrast-enhanced endoscopic ultrasound for the differential diagnosis of chronic pseudotumoral pancreatitis and pancreatic cancer[J]. BMC Gastroenterol,2013,13:2.
    [11] LEE TY,CHEON YK,SHIM CS. Clinical role of contrast enhanced harmonic endoscopic ultrasound in differentiating solid lesions of the pancreas:A single-center experience in Korea[J]. Gut Liver,2013,7(5):599-604.
    [12] HOU XJ,JIN ZD,ZHAN XB,et al. Efficacy of contrast-enhanced harmonic endoscopic ultrasonography in the differentiation of pancreatic cancer and focal pancreatitis[J]. Chin J Pancreatol,2014,14(6):370-373.(in Chinese)侯晓佳,金震东,湛先保,等.谐波造影增强内镜超声对胰腺癌与局灶型胰腺炎的鉴别诊断价值[J].中华胰腺病杂志,2014,14(6):370-373.
    [13] PARK JS,KIM HK,BANG BW,et al. Effectiveness of contrast-enhanced harmonic endoscopic ultrasound for the evaluation of solid pancreatic masses[J]. World J Gastroenterol,2014,20(2):518-524.
    [14] S AˇFTOIU A,VILMANN P,DIETRICH CF,et al. Quantitative contrast enhanced harmonic EUS in differential diagnosis of focal pancreatic masses(with videos)[J]. Gastrointest Endosc,2015,82(1):59-69.
    [15] YAMASHITA Y,KATO J,UEDA K,et al. Contrast-enhanced endoscopic ultrasonography for pancreatic tumors[J]. Biomed Res Int,2015,2015:491782.
    [16] IORDACHE S,COSTACHE MI,POPESCU CF,et al. Clinical impact of EUS elastography followed by contrast-enhanced EUS in patients with focal pancreatic masses and negative EUS-guided FNA[J]. Med Ultrason,2016,18(1):18-24.
    [17] UEKITANI T,KAINO S,HARIMA H,et al. Efficacy of contrast enhanced harmonic endoscopic ultrasonography in the diagnosis of pancreatic ductal carcinoma[J]. Saudi J Gastroenterol,2016,22(3):198-202.
    [18] IGLESIAS-GARCIA J,LINDKVIST B,LARIO-NOIA J,et al. Differential diagnosis of solid pancreatic masses:contrast-enhancedharmonic(CEH-EUS),quantitative-elastography(QE-EUS),or both?[J]. United European Gastroenterol J,2017,5(2):236-246.
    [19] SEICEAN A,BADEAR R,MOLDOVAN-POP A,et al. Harmonic contrast-enhanced endoscopic ultrasonography for the guidance of fine-needle aspiration in solid pancreatic masses[J]. Ultraschall Med,2017,38(2):174-182.
    [20] CHO MK,MOON SH,SONG TJ,et al. Contrast-enhanced endoscopic ultrasound for differentially diagnosing autoimmune pancreatitis and pancreatic cancer[J]. Gut Liver,2018,12(5):591-596.
    [21] HARMSEN FR,DOMAGR D,DIETRICH CF,et al. Discriminating chronic pancreatitis from pancreatic cancer:Contrast-enhanced EUS and multidetector computed tomography in direct comparison[J]. Endosc Ultrasound,2018,7(6):395-403.
    [22] DEVILLWL,BUNTINX F,BOUTER LM,et al. Conducting systematic reviews of diagnostic studies:Didactic guidelines[J].BMC Med Res Methodol,2002,2:9.
    [23] CHU Q,GONG TT,XIONG HF,et al. Contrast enhanced EUS for pancreatic diseases[J]. Chin J Dig Endosc,2010,27(11):576-580.(in Chinese)褚琦,龚婷婷,熊慧芳,等,造影增强内镜超声对胰腺病变定量分析价值的初步探讨[J].中华消化内镜杂志,2010,27(11):576-580.
    [24] HE Q,XU YQ. Application of endoscopic ultra sonography in diagnosis of pancreatic cancer and related research advances[J]. J Clin Hepatol,2016,32(7):1280-1282.(in Chinese)何强,徐有青.超声内镜在胰腺癌诊断中的应用及进展[J].临床肝胆病杂志,2016,32(7):1280-1282.
    [25] WANG L,ZOU DW,LI ZS. Application of endoscopic ultrasound in the diagnosis of autoimmune pancreatitis[J]. J Clin Hepatol,2018,34(8):1609-1613.(in Chinese)王雷,邹多武,李兆申.超声内镜在自身免疫性胰腺炎诊断中的应用[J].临床肝胆病杂志,2018,34(8):1609-1613.
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