中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 6
Jun.  2012

Recent progress in diagnosis, prevention and treatment of drug-induced liver injury

  • Published Date: 2012-06-20
  • Drug-induced liver injury (DILI) occurs when drugs or their metabolites cause damage to hepatic tissues.In recent years, DILI has been recognized as a significant cause of both acute and chronic liver disease.The current estimates of DILI incidence worldwide range from 1 in 10, 000 to 1 in 100, 000, and the reported annual incidence rates have increased in parallel with increases in development of new drugs and more widespread clinical applications.There is an urgent clinical need to more effectively recognize at-risk patients and diagnose DILI in a timely manner.In this article, we will review the latest research findings concerning several important clinical aspects of DILI, including risk factors, clinical presentation, diagnosis, causality assessment, early clinical detection, and prevention strategies.

     

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