Objective To explore the incidence and clinical feature of primary biliary cirrhosis (PBC) combined with diabetes mellitus (DM) .Methods Clinical data of 81 cases of PBC were analyzed retrospectively in our hospital between Jan.2000 and Jul.2010.The clinical features, complications, liver function index, immunologica1 features and gastroscope performance was compared between the group of PBC combined with DM (DM group) and group of PBC without DM (non-DM group) .Results The incidence of PBC combined with DM was 19.6%.The proportion of patients with leg edema, ascites and hydrothorax complications was obviously higher in DM group than in non-DM group (43.8% vs 15.4%, P=0.03;75.0% vs 30.8%, P=0.001;25% vs 25%, P=0.01) .The anti-mitochondrial antibody M2 level was (91.3±65.7) Ru/ml in DM group, significantly lower than that in the non-DM group (171.1±84.0) Ru/ml, P=0.03.While there was no significant difference in liver function index between the two groups.Conclusion As the clinical manifestations were not typical, it is important for PBC patients combined with DM to monitor the blood sugar, timely diagnose and manage diabetes.
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