Mechanism of bile secretion, excretion, regulation and cholestasis

Lu LunGen

Issue 6

Jun. 2011

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Article Navigation > Journal of Clinical Hepatology > 2011 > 27(6): 570-571+580

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Mechanism of bile secretion, excretion, regulation and cholestasis

Lu LunGen

Published Date: 2011-06-20

Abstract

Abstract

Formation, secretion and excretion of bile acids are complex process.Both hepatocytes and cholangiocytes might ingest and secrete the composition of bile acids, mainly depending on their membrane transporters which play an important role in its pathological and physiological processes.Cholestasis can result from either a functional defect in bile formation at the level of the hepatocytes or from impairment in bile secretion and flow at the bile duct level.In this paper, mechanism of bile secretion, excretion, regulation and cholestasis was reviewed.
- bile,
- bile excretion,
- cholestasis

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References(9)

References

[1]Hofmann AF.Bile acids:trying to understand their chemistry and biology with the hope of helping patients[J].Hepatology, 2009, 49 (5) :1403-1418.

[2]Monte MJ, Marin JJ, Antelo A, et al.Bile acids:chemistry, physiology, and pathophysiology[J].World J Gastroenterol, 2009, 15 (7) :804-816.

[3]Esteller A.Physiology of bile secretion[J].World J Gastroenterol, 2008, 14 (37) :5641-5649.

[4]Hofmann AF.The enterohepatic circulation of bile acids in mammals:form and functions[J].Front Biosci, 2009, 14:2584-2598.

[5]Stapelbroek JM, van Erpecum KJ, klomp LW, et al, Houwen RH.Liver disease associated with canalicular transport defects:current and future therapies[J].J Hepatol, 2010, 52 (2) :258-271.

[6]Maillette de Buy Wenniger L, Beuers U.Bile salts and cholestasis[J].Dig Liver Dis, 2010, 42 (6) :409-418.

[7]Dawson PA, Lan T, Rao A.Bile acid transporters[J].J Lipid Res, 2009, 50 (12) :2340-2357.

[8]Kosters A, Karpen SJ.The role of inflammation in cholestasis:clinical and basic aspects[J].Semin Liver Dis, 2010, 30 (2) :186-194.

[9]Paumgartner G.Biliary physiology and disease:reflections of a physician-scientist[J].Hepatology, 2010, 51 (4) :1095-1106.

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沈阳化工大学材料科学与工程学院沈阳 110142

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Mechanism of bile secretion, excretion, regulation and cholestasis

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