Mechanism of action of bile acid metabolism in regulating cholestatic liver disease and the research and development of drugs

Jing LI; Kuiyang ZHENG; Beibei ZHANG

doi:10.3969/j.issn.1001-5256.2021.10.048

Volume 37 Issue 10

Oct. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(10): 2482-2487

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Mechanism of action of bile acid metabolism in regulating cholestatic liver disease and the research and development of drugs

DOI: 10.3969/j.issn.1001-5256.2021.10.048

Department of Pathogenic Biology and Immunology, Xuzhou Medical University; Laboratory of Infection and Immunology, Xuzhou Medical University; Jiangsu Key Laboratory of Immunology and Metabolism, Xuzhou, Jiangsu 221004, China

Research funding:

Natural Science Foundation of Jiangsu Province of China (BK20201011);

Natural Science Foundation of the Jiangsu Higher Education Institutions of China (20KJB310011);

Jiangsu Postdoctoral Science Foundation (RC7062005);

Graduate Research Innovation Plan (KYCX20-2468)

Received Date: 2021-02-05
Accepted Date: 2021-03-08
Published Date: 2021-10-20

Abstract

Abstract

Bile acids are the end products of cholesterol metabolism and are classified as primary bile acids and secondary bile acids. They can promote nutrition absorption and regulate immune response, glucose/lipid/energy metabolism, and microbiota homeostasis by acting on bile acid nuclear receptors and membrane receptors. Cholestatic liver disease (CLD) is a type of liver disease caused by abnormalities of the hepatobiliary system due to cholestasis, with the initial manifestations of hepatocyte and/or bile duct injury, which further leads to abnormal bile acid synthesis, secretion, and excretion. In-depth studies have gradually revealed the role and mechanism of bile acids in CLD, and drugs targeting the action sites of bile acids are under research and development. This article elaborates on the role and mechanism of bile acid metabolism in CLDand summarizes the research and development of drugs for CLD treatment based on bile acid metabolism, so as to provide a reference for future research on the prevention and treatment of CLD.
- Cholestasis,
- Cholic Acids,
- Pathologic Processes,
- Drug Design

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References

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Mechanism of action of bile acid metabolism in regulating cholestatic liver disease and the research and development of drugs

DOI: 10.3969/j.issn.1001-5256.2021.10.048

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Mechanism of action of bile acid metabolism in regulating cholestatic liver disease and the research and development of drugs

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