The effect of Telbivudine on virus serology and liver biopsy in HBV carriers

Objective To observe the changes on virus serology and liver biopsy among HBV carriers treated with Telbivu-dine.Methods 42 HBV carriers were divided randomly into treatment group and control group.Telbivudine 100 mg/d was given orally for the treatment group for more than one year.Oxymatrine capsule was given orally for the control group for six months.Liver biopsy and HBVM, HBVDNA and liver fibrosis indexes were tested during the treatment.Results After six months of treatment the improvement of liver biopsy and HBVM, HBVDNA, and liver fibrosis indexes improved significant-ly in the treatment group than the control group (P < 0.05) , and the index of hepatic inflammation activity in the treatment group decreased from 7.8 ± 3.8 to 4.5 ± 4.2 (t = 7.358, P < 0.01) .Conclusion Telbivudine therapy has a significant short-term curative effect on HBV carriers.