Short-term clinical effect of telbivudine in the treatment chronic hepatitis B

Li Zhi; Yan HongMei; Xue FaXuan; Wang Tong; Liang Qun; Xu Huan; Li ZhangChun

Issue 6

Jun. 2009

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > Journal of Clinical Hepatology > 2009 > 25(6): 420-421+426

PDF( 170 KB)

替比夫定治疗慢性乙型肝炎37例近期疗效观察

Published Date: 2009-06-20

Abstract

Abstract

Objective To study the efficacy and safety of telbivudine in the treatment of chronic hepatitis B (CHB) .Methods A total 37 patients with CHB were divided in to two groups.Group one (n=21) patients were treated with telbivudine from the beginning and group two (n=16) patients were treated with telbivudine after treatment failure with adefovir dipivoxil.Each patient received 600mg daily for 24 weeks.Serum ALT, HBV DNA and creatine kinase levels were measured before and after treatment.Results After treatment, the level of serum ALT decreased dramatically in both groups (p<0.05) but the decrease was not statistically significant between the two groups.After one month of treatment the mean reduction of HBV DNA from baseline didn't show significant difference between the two groups, but it reduced significantly after 3 to 6 months of treatment (p<0.05) .There was no significant difference in HBV DNA level and HBeAg seroconversion between the two groups at the end of treatment.Conclusion Telbivudine seems to be effective and safe in viral load reduction if it is taken at the beginning of treatment.
- telbivudine,
- hepatitis B

FullText(HTML)

References(11)

References

[1]庄辉.病毒性肝炎的流行病学[J].中国计划免疫, 2004, 10 (3) ∶180-181.

[2]Hodge RA.Telbivudine/Torcitabine idenix/Novartis[J].Curr Op in Invest Drugs, 2004, 5∶232-241.

[3]Tacke F, Trautwein C.Hepatitis B goes globe:Telbivudine as a new treatment option[J].Hepatology, 2008, 47 (5) ∶1786-1787.

[4]汪月娥.耐药所致治疗失效的临床结局[J].肝脏, 2007, 12 (增刊) ∶37-39.

[5] 中华医学会.慢性乙型肝炎防治指南[J].中华肝脏病杂志, 2005, 13∶881-891.

[6]梁月兰, 黄春新.治疗慢性乙肝新药-素比伏 (替比夫定片) [J].中南药学, 2007, 5 (3) ∶285-287.

[7]Zhou XJ, Lim SG, Lloyd DM, et al.Pharmacokinetics of telbivudine following oral administration of escalating single and multip le doses in patientswith chronic hepatitis B virus infection:pharrnacodynamic implications[J].Antimicrob Agents Chemother, 2006, 50 (3) ∶874-879.[8]许洁, 陆志檬.替比夫定治疗慢性乙型肝炎的进展[J].中华肝脏病杂志, 2006, 14 (12) ∶958-960.

[9]Zhou XJ, Fielman BA, Lloyd DM, et al.Pharmacokinetics of telbivu-dine in healthy subjects and absence of drug interaction with lamivu-dine or adefovir dip ivoxil[J].Antimicrob Agents Chemother, 2006, 50 (7) ∶2309-2315.

[10]邓中平.恩替卡韦治疗乙型肝炎的疗效及安全性[J].中国新药与临床杂志, 2005, 24 (4) ∶326-329.

[11]张雪松, 金瑞.替比夫定单用及与阿德福韦或干扰素联用出现肌病的初步观察[J].药物不良反应杂志, 2008, 10 (3) ∶180-183.

[12]Kohnke H, Sorl INK, Granath G, et al.Warfarin dose related to apo-lipop rotein E (APOE) genotype[J].Eur J Clin Pharm acol, 2005, 61 (5-6) ∶381-388.

Relative Articles

[1]	Li Na, Gou Wei, Cui WeiLi. Efficacy of telbivudine combined with adefovir dipivoxil and pegylated interferon combined with entecavir as antiviral therapy for chronic hepatitis B: a comparative analysis[J]. Journal of Clinical Hepatology, 2016, 32(9): 1714-1716. doi: 10.3969/j.issn.1001-5256.2016.09.015
[2]	Peng MeiJuan, Wang Wei, Yang XiaoFei, Hao ChunQiu, Bai XueFan, Jia ZhanSheng, Lian JianQi, Zhang Ye. Influence of pegylated interferonα- 2a versus telbivudine on renal function in patients with chronic hepatitis B[J]. Journal of Clinical Hepatology, 2016, 32(4): 682-686. doi: 10.3969/j.issn.1001-5256.2016.04.014
[3]	Huang ShuiWen, Liu BaoRong, Chen MingSheng, Lin Chun, Zhou Rui, Yang HuiAn, Jiang XiaoYan, Pan Chen, Li DongLiang. Establishment of a predictive model for early virologic response in previously untreated chronic hepatitis B patients treated with telbivudine[J]. Journal of Clinical Hepatology, 2016, 32(7): 1287-1291. doi: 10.3969/j.issn.1001-5256.2016.07.014
[4]	Wang Fang, Quan ZuoHua, Yang XingKun, Kou JunFeng, Yun ShengHao, Cai GuoFang, Zhou XinRen. Influence of antiviral therapy with telbivudine on serum soluble complement receptor type 1 in patients with chronic hepatitis B or liver cirrhosis[J]. Journal of Clinical Hepatology, 2016, 32(6): 1118-1120. doi: 10.3969/j.issn.1001-5256.2016.06.019
[5]	Li HuoYan, Yang ZhaoHui, Ma LiLi, Ma Long. Clinical efficacy of telbivudine and interferon in treatment of HBe Ag-positive chronic hepatitis B: a comparative study[J]. Journal of Clinical Hepatology, 2015, 31(4): 526-529. doi: 10.3969/j.issn.1001-5256.2015.04.012
[6]	Wang RongQi, Nan YueMin. Neutropenia caused by telbivudine in chronic hepatitis B patients: a report of one case[J]. Journal of Clinical Hepatology, 2015, 31(2): 273-274. doi: 10.3969/j.issn.1001-5256.2015.02.031
[7]	Guo RuYi, Yu XuePing, Su ZhiJun, Lin ChengZu, Lin ZhiPeng, Lin Qi. Evaluation of telbivudine’s efficacy for treating HBeAg-positive chronic B hepatitis patients and identification of its predictive factors by logistic regression analysis[J]. Journal of Clinical Hepatology, 2013, 29(2): 97-100.
[8]	Dong XiaoPing. Therapeutic effect of telbivudine combined with Fuzheng Huayu tablets in treatment of liver fibrosis in chronic hepatitis B: a report of 60 cases[J]. Journal of Clinical Hepatology, 2013, 29(9): 689-691. doi: 10.3969/j.issn.1001-5256.2013.09.014
[9]	Jiang XiuNong, Fan LingYan, Li DeZhou, Wan Jiong, Ye JingJing. Clinical trial of telbivudine in the treatment of chronic hepatitis B in patients during the third trimester of pregnancy[J]. Journal of Clinical Hepatology, 2013, 29(2): 101-103.
[10]	Zhang XueHua, Zhu ChuanWu, Luo XiangRong, Chai XiaoZhe. Therapeutic efficacy of telbivudine for treating chronic hepatitis B patients with elevated levels of serum soluble E-selectin[J]. Journal of Clinical Hepatology, 2012, 28(11): 839-840+844.
[11]	Xie Rong, Jiang JianNing, Su MingHua, Liu ZhiHong, Zhong ShaoHua, He LiXia, Liang YanXiu, Hu JiaGuang, Huang XiaoHong, Guo WenWen, Fu WuDao, Zhu MeiQin, Wang BaoJian. Efficacy and safety of initial telbivudine treatment in chronic hepatitis B patients[J]. Journal of Clinical Hepatology, 2012, 28(6): 422-424+427.
[12]	Zhao WenLi, Wang BaoChun, Huang Fei. Therapeutic effects of 48-week telbivudine treatment in patients with cirrhosis caused by HBV[J]. Journal of Clinical Hepatology, 2011, 27(8): 840-843.
[13]	Yao QinJiang, Ma WeiGuo. Therapeutic efficacy of telbivudine in hepatitis B e antigen positive chronic hepatitis B patients with high baseline alanine aminotransferase levels[J]. Journal of Clinical Hepatology, 2011, 27(6): 614-616.
[14]	Song LiWen, Zhao GuiMing, Cao WuKui, Lu ChengZhen. Meta analysis of the comparison of the efficacy of lamivudine and telbivudine in the treatment of chronic hepatitis B[J]. Journal of Clinical Hepatology, 2011, 27(9): 955-961.
[15]	Wang HaiYan, Wang Yu, Peng XiaoMing, Liu Ya. Recent advancement of telbivudine in the treatment of chronic hepatitis B[J]. Journal of Clinical Hepatology, 2011, 27(12): 1320-1322+1326.
[16]	Zhan GuoQing, Tan HuaBing, Zhang WeiWei, Li RuGui, Xie XingRong, Hu Bo. The factors predicting the efficacy of telbivudine in the treatment of HBeAg-positive chronic hepatitis B[J]. Journal of Clinical Hepatology, 2011, 27(6): 608-610.
[17]	Jin QingLong, Wang ZhongFeng, Yan HongQing, Niu JunQi. The study of the change in creatine kinase in patients with chronic hepatitis B during the antiviral treatment with Telbivudine and Lamivudine[J]. Journal of Clinical Hepatology, 2011, 27(2): 143-144+156.
[18]	Wu HangYuan, You DeHong. The efficacy of Telbivudine therapy on decompensated hepatitis B cirrhosis documentation[J]. Journal of Clinical Hepatology, 2010, 26(6): 605-607.
[19]	Zhang WeiWei, Yuan XueHua, Tan HuaBing, Zhan GuoQing, Li RuGui, Du WeiXing. Therapeutic Efficacy of telbivudine with phentolamine on patients with chronic severe hepatits B[J]. Journal of Clinical Hepatology, 2009, 25(6): 418-419.

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views (2359) PDF downloads(815)

替比夫定治疗慢性乙型肝炎37例近期疗效观察

Abstract

References

Relative Articles

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

替比夫定治疗慢性乙型肝炎37例近期疗效观察

Abstract

References

Relative Articles

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

About Journal

Submission Guideline

Journal Online

Hepatobiliary College

Guidelines

Export File

Citation

Format

Content