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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 6
Jun.  2016
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Influence of antiviral therapy with telbivudine on serum soluble complement receptor type 1 in patients with chronic hepatitis B or liver cirrhosis

DOI: 10.3969/j.issn.1001-5256.2016.06.019
  • Published Date: 2016-06-20
  • Objective To investigate the changes in serum soluble complement receptor type 1(s CR1) at 3 and 6 months after antiviral therapy with telbivudine in patients with chronic hepatitis B(CHB) or liver cirrhosis and the influence of telbivudine on serum s CR1 level.Methods A total of 57 patients with HBe Ag- positive CHB or liver cirrhosis were enrolled and given the antiviral therapy with telbivudine.Venous blood was collected before treatment and at 3 and 6 months after treatment,and enzyme- linked immunosorbent assay was used to measure serum s CR1 level.The paired t- test was used for comparison within one group.Results At 3 and 6 months after the antiviral treatment with telbivudine,the serum s CR1 level changed significantly compared with corresponding baseline values(t = 4.864 and 6.238,both P < 0.05).The patients with CHB or liver cirrhosis showed significant changes in the serum s CR1 level at 3 and 6 months after treatment compared with corresponding baseline values(t = 3.425,5.468,4.047,7.378 all P < 0.05).The patients with CHB had a lower serum s CR1 level at baseline and at 3 and 6 months after treatment than those with liver cirrhosis,but the serum s CR1 level at each time point showed no significant differences between the two groups(all P > 0.05).Conclusion In patients with HBe Ag- positive CHB or liver cirrhosis,serum s CR1 level is reduced significantly after antiviral therapy with telbivudine.

     

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