The relationship between serum NO and response to interferon α in patients with chronic hepatitis B

Lu XianZhong; Liu JinXia; Bian PengFei; Chen ShiJun; Zhu ChengBao; Du WenJun

Issue 6

Jun. 2009

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Article Navigation > Journal of Clinical Hepatology > 2009 > 25(6): 410-412

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慢性乙肝患者血清一氧化氮的表达与α干扰素抗病毒应答的相关性研究

Published Date: 2009-06-20

Abstract

Abstract

Objective To determine the effect of NO on the progression of CHB and the relationship between NO and efficacy of interferon α (INF α) .Methods 40 CHB patients treated with IFN α and 20 healthy controls were included in the study.Serum NO concentration was determined at base line, and 12 and 24 weeks after treatment.At the end of treatment, these patients were divided in to two groups according to the response to INF α.Results The serum NO concentration in CHB patients was significantly higher than that of the control group (p<0.01) .ALT level was positively correlated with serum NO concentration (r=0.673, p<0.001) .Among the patients responded to INF α, the NO concentration decreased gradually during the treatment.The NO concentration at 12 and 24 weeks were both significantly higher than the baseline (p<0.01) and had no significant change during IFN treatment in non responders (p>0.05) Conclusion NO may play an important role in the pathogenesis of CHB, and can be used as a predictor of treatment response.
- Chronic hepatitis B,
- nitric oxide,
- interferon α

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沈阳化工大学材料科学与工程学院沈阳 110142

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慢性乙肝患者血清一氧化氮的表达与α干扰素抗病毒应答的相关性研究

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慢性乙肝患者血清一氧化氮的表达与α干扰素抗病毒应答的相关性研究

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