Changes in peripheral T-lymphocytes subsets and CD28 subsets in patients with chronic HBV infected

Yan ShuangHuan; Chen CuiYing; Cao ZhiChen; Liu JinXia

Issue 5

May 2009

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Article Navigation > Journal of Clinical Hepatology > 2009 > 25(5): 328-330

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慢性HBV感染者T细胞亚群与CD28亚群的变化

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Published Date: 2009-05-20

Abstract

Abstract

Objective To investigate the changes of T-lymphocyte subsets and CD28 subsets in different types of HBV infected patients.Methods 20 patients with CHB were selected.Simultaneously 15 HBsAg carriers whose liver function were normal were selected.And 20 healthy volunteers were served as normal control.Flow cytometry was used to detect the T-lymphocyte subsets and CD28 functional subsets.Results Compared with normal controls, the numbers of CD4+ T cells, CD4+CD28+T cells and CD8+CD28+T cells decreased in CHB patients and HBV carriers (P<0.05) , whereas there was no significant difference between HBsAg carriers and normal controls (P>0.05) .Conclusion Different immune response resulted in different types of HBV infection.
- HBV,
- T-lymphocyte subsets,
- CD28 subsets,
- immune response

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慢性HBV感染者T细胞亚群与CD28亚群的变化

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慢性HBV感染者T细胞亚群与CD28亚群的变化

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