The study on imblance of cytotoxic T cells subtype (Tc1/Tc2) in patients with chronic hepatitis B

Zhao Shuang; Yan XueBing; Wang JinZhang; Hao JunGui; Wang MingShan; Feng Xia; Wan MeiRong

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Jun. 2008

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Article Navigation > Journal of Clinical Hepatology > 2008 > 24(6): 417-419

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慢性乙型肝炎外周血细胞毒性T细胞亚群(Tc1/Tc2)失衡的研究

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Published Date: 2008-06-20

Abstract

Abstract

Objective To investigate the effects of the cytotoxic T (Tc) cells subtypes on the pathogenesis of chronic hepatitis B (CHB) and HBV-liver cirrhosis (LC) .Methods Using flow cytometry, the expression levels of Tc1 (CD8/CCR5) and Tc2 (CD8/CD30) of PMBC of 75 CHB patients, 40 LC patients and 20 normal controls (NC) were assayed respectively.Results Tc1 in CHB and LC patients were higher than those in NC (P<0.05) , and Tc2 in LC patients were lower than in CHB and NC (P<0.05) .Tc1 and Tc2 in gravis hepatitis patients were lower than CHB.While Tc1/Tc2 in CHB and LC were higher than that in NC.Conclusions The subtype responsive is different between CHB and Nc Tc subtype imbalance plays an important role in the pathogenesis of CHB and LC.
- Chronic hepatitis B,
- Cytotoxic T cells,
- HBV-liver cirrhosis

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[1]Shibole O, Alper R, Zolotorav L, et al.The role of intrahepatic CD8+Tcell trapping and NK1.1+cells in liver-mediated immune regulation[J].Clin Immunol, 2004, 111 (1) :82-92.

[2]Webster GJ, Reignat S, Maini MK, et al.Incubation phase of acute hepatitis B in man dynamic of cellular immune mechanisms[J].Hep-atology, 2000, 32 (5) :1117-1124.

[3]Maini MK, Boni C, Lee CK, et al.The role of virus-specific CD8+cells in liver damage and viral control during persistent hepati-tis B virus infection[J].Exp Med, 2000, 191 (8) :1269-1280.

[4]Westover KM, Hughes AL.Evolution of cytotoxic T-lymphocyte epitopes in hepatitis B virus Infect Genet Evol[J].2007, 7 (2) :254-262.

[5]Maggi E, Manetti R, Annunziato F, et al.Functional characteriza-tion and modulation of cytokine production by CD8+Tcells from hu-man immuncdeficiency virus-infected individuals[J].Blood, 1997, 89 (10) :3672-3681.

[6]欧强, 陈良, 孙洪清, 等.慢性HBV感染者外周血T淋巴细胞亚群和NK细胞活性变化[J].临床肝胆病杂志, 2006, 22 (4) :277-278.

[7]王娟华, 谢志平, 裴浩, 等.HBV慢性感染患者外周血Th1/Th2 (Tc1/Tc2) 细胞IFN-γ和IL-4的表达及其临床意义[J].第三军医大学报, 2004, 26 (18) :1646-1649.

[8]周茂华, 王丁, 张建军, 等.乙型肝炎患者外周血细胞中Th1PTh2型细胞因子的表达及其临床意义[J].中华免疫学杂志, 2003, 19 (10) :725-727.

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慢性乙型肝炎外周血细胞毒性T细胞亚群(Tc1/Tc2)失衡的研究

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慢性乙型肝炎外周血细胞毒性T细胞亚群(Tc1/Tc2)失衡的研究

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