The study on imblance of cytotoxic T cells subtype (Tc1/Tc2) in patients with chronic hepatitis B

Zhao Shuang; Yan XueBing; Wang JinZhang; Hao JunGui; Wang MingShan; Feng Xia; Wan MeiRong

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Jun. 2008

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Article Navigation > Journal of Clinical Hepatology > 2008 > 24(6): 417-419

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慢性乙型肝炎外周血细胞毒性T细胞亚群(Tc1/Tc2)失衡的研究

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Published Date: 2008-06-20

Abstract

Abstract

Objective To investigate the effects of the cytotoxic T (Tc) cells subtypes on the pathogenesis of chronic hepatitis B (CHB) and HBV-liver cirrhosis (LC) .Methods Using flow cytometry, the expression levels of Tc1 (CD8/CCR5) and Tc2 (CD8/CD30) of PMBC of 75 CHB patients, 40 LC patients and 20 normal controls (NC) were assayed respectively.Results Tc1 in CHB and LC patients were higher than those in NC (P<0.05) , and Tc2 in LC patients were lower than in CHB and NC (P<0.05) .Tc1 and Tc2 in gravis hepatitis patients were lower than CHB.While Tc1/Tc2 in CHB and LC were higher than that in NC.Conclusions The subtype responsive is different between CHB and Nc Tc subtype imbalance plays an important role in the pathogenesis of CHB and LC.
- Chronic hepatitis B,
- Cytotoxic T cells,
- HBV-liver cirrhosis

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慢性乙型肝炎外周血细胞毒性T细胞亚群(Tc1/Tc2)失衡的研究

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慢性乙型肝炎外周血细胞毒性T细胞亚群(Tc1/Tc2)失衡的研究

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