Expression of NF-κB and ERK-1mRNA in rat with liver fibrosis

Hu TaiHong; Jiang XiangHu; Jiang YueMing; Zhou Min; Xu Min; Zhu Rui; Yang Ling

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Jan. 2009

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Article Navigation > Journal of Clinical Hepatology > 2009 > 25(1): 23-25

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肝纤维化大鼠肝组织中NF-κB及ERK-1mRNA的表达

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Published Date: 2009-01-20

Abstract

Abstract

Objective To evaluate Expression of NF-κB and ERK-1mRNA in rat with liver fibrosis.Methods Liver fibrosis in rats were induced by carbon tetrachloride (CCl4) .Rats were divided into two groups: normal control group, CCl4 model group.The expression of alpha-Smooth Muscle Action were detected by immunohistochemistry.The mRNA expression of nuclear factor kappaB (NF-κB) and extracellular signal-regulated kinase (ERK-1) were determined by RT-PCR.Results The mRNA expression of NF-κB and ERK-1 were significantly higher in model group (P<0.01) .Conclusion The activation of ERK signal transduction pathway enhances HSC proliferation of rats;on the other hand, the enhanced signal of nuclear factor kappaB may accelerate the procedure of liver fibrosis.Both of them may play an important role in liver fibrogenesis of rat.
- NF-κB,
- ERK-1,
- liver fibrosis

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[5]Son G, Iimuro Y, Seki E, et al.Selective inactivation of NF-kap-paB in the liver using NF-kappaB decoy suppresses CCl4-inducedliver injury and fibrosis[J].Am J Physiol Gastrointest Liver Physiol, 2007, 293 (3) ∶G631-9.

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沈阳化工大学材料科学与工程学院沈阳 110142

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肝纤维化大鼠肝组织中NF-κB及ERK-1mRNA的表达

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肝纤维化大鼠肝组织中NF-κB及ERK-1mRNA的表达

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