Research advances in the cascade interaction between reactive oxygen species/reactive nitrogen species and the NF-κB signaling pathway in liver fibrosis

Yuanqian MIN; Shan LI; Xianghua LIU; Yi YANG; Ningning LI; Baoping LU

doi:10.3969/j.issn.1001-5256.2023.06.031

Volume 39 Issue 6

Jun. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(6): 1454-1460

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Research advances in the cascade interaction between reactive oxygen species/reactive nitrogen species and the NF-κB signaling pathway in liver fibrosis

DOI: 10.3969/j.issn.1001-5256.2023.06.031

Yuanqian MIN^1a,
Shan LI^1b,
Xianghua LIU^1c,
Yi YANG^1b,
Ningning LI²,
Baoping LU^{1d
,
,
,}

1a.
The Second Clinical Medical School, Henan University of Chinese Medicine, Zhengzhou 450046, China
1b.
School of Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China
1c.
Academy of Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China
1d.
Institute of Hepatology, Henan University of Chinese Medicine, Zhengzhou 450046, China
2.
Henan Medical College, Zhengzhou 451191, China

Research funding:

The Special Research Project of Traditional Chinese Medicine in Henan Province (2022ZY1167);

The Training Program for Young Scholars in Universities of Henan Province (2021GGJS084);

The Important Scientific Research Project of Universities in Henan Province (21B310003)

More Information

Corresponding author: LU Baoping, lbp1921@sohu.com (ORCID: 0000-0002-3707-2185)
Received Date: 2022-10-18
Accepted Date: 2022-11-16
Published Date: 2023-06-20

Abstract

Abstract

Liver fibrosis is a compensatory response in the process of tissue repair after chronic liver injury, and it is also a necessary pathological process in the progression of a variety of chronic liver diseases. In the pathological state, the imbalance between hepatic oxidative system and antioxidant system can lead to the excessive production or insufficient clearance of reactive oxygen species (ROS)/reactive nitrogen species (RNS), which may induce the injury of hepatocytes, expand inflammatory response, and promote the development and progression of liver fibrosis. As a master regulator of oxidative stress and inflammatory response, NF-κB plays a key role in the process of liver fibrosis. Therefore, the cascade interaction between ROS/RNS and the NF-κB signaling pathway plays a guiding role in further clarifying the pathogenesis of liver fibrosis and exploring effective prevention and treatment strategies. This article reviews and discusses the interaction between ROS/RNS and the NF-κB signaling pathway and its important role in the progression of liver fibrosis, so as to provide strategies and references for targeted therapy for liver fibrosis.
- Liver Fibrosis,
- Oxidative Stress,
- Reactive Oxygen Species,
- Reactive Nitrogen Species,
- NF-kappa B

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References(42)

References

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Research advances in the cascade interaction between reactive oxygen species/reactive nitrogen species and the NF-κB signaling pathway in liver fibrosis

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Research advances in the cascade interaction between reactive oxygen species/reactive nitrogen species and the NF-κB signaling pathway in liver fibrosis

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