Clinico-pathological significance of intratumoral microvessel density and estrogen receptor expression in hepatocellular carcinoma

Zhang GuoShuan; Cui ZhuanYi; Zheng ZhiMin; Wang GuiQi; Qin SuLi

Issue 3

Mar. 2006

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Article Navigation > Journal of Clinical Hepatology > 2006 > 22(3): 199-201

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肝细胞肝癌微血管密度与雌激素受体表达的临床病理意义

Published Date: 2006-03-20

Abstract

Abstract

To explore the relationship between intra tumoral microvessel density and estrogen receptor expression in hepatocellular carcinoma, and their relationship with the prognostic factors.36 patients with HCC were disparted into two groups: ER negative group and ER positive group.According to MVD value, they were disparted into MVDmedian group, and the established prognostic factors were compared.There were 14 ER (+) and 22 ER (-) cases, MVD value ranged from 3 to 121 (44.67±32.15 median=36) .Significant associations were found between ER status and tumor size, encapsulation and serum AFP concentration.Significant associations were found between MVD and the number of nodules, tumor size, Edmonson-Steiner class and serum AFP concentration.Inverse association was found between ER status and MVD.This shows: (1) ER positive or lower MVD in HCC has lesser malignant biological behavior than ER negative or higher MVD in HCC respectively. (2) Both ER status and MVD are good prognostic factors.
- hepatocellular carcinoma,
- microvessel density,
- estrogen receptor

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沈阳化工大学材料科学与工程学院沈阳 110142

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肝细胞肝癌微血管密度与雌激素受体表达的临床病理意义

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肝细胞肝癌微血管密度与雌激素受体表达的临床病理意义

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