HBx、Twist、E-cadherin及N-cadherin在肝细胞肝癌中的表达及意义

Objective To investigate the expression and clinical significance of HBx, Twist, E-cadherin and N-cadherin in hepatocellular carcinoma (HCC) .Methods The expression of HBx, Twist, E-cadherin and N-cadherin in HCC and adjacent tissues were detected by immunohistochemistry technique and the relationship with clinicopathological features was analyzed.Results The positivity rate of HBx, Twist, E-cadherin and N-cadherin were 84.7%, 80.6%, 52.8% and 45.8% in HCC tissues and 81.9%, 51.4%, 70.8% and 27.8% in adjacent tissues, respectively.There was a statistically significant difference in Twist, E-cadherin and N-cadherin between the HCC and adjacent tissues (p<0.05) .The expression of HBx was positively correlated with Twist and N-cadherin in HCC and adjacent tissues, respectively.E-cadherin was negatively correlated with HBx, Twist and N-cadherin.Conclusion The higher expression of HBx, Twist, N-cadherin and E-cadherin are correlated with the invasion and metastasis of HCC.HBx might promote the change of epithelial-mesenchymal transition of HCC through Twist upregulation.